Simultaneous Three-Degrees-of-Freedom Prosthetic Control Based on Linear Regression and Closed-Loop Training Protocol.

Machine learning-based controllers of prostheses using electromyographic signals have become very popular in the last decade. The regression approach allows a simultaneous and proportional control of the intended movement in a more natural way than the classification approach, where the number of movements is discrete by definition. However, it is not common to find regression-based controllers working for more than two degrees of freedom at the same time. In this paper, we present the application of the adaptive linear regressor in a relatively low-dimensional feature space with only eight sensors to the problem of a simultaneous and proportional control of three degrees of freedom (left-right, up-down and open-close hand movements). We show that a key element usually overlooked in the learning process of the regressor is the training paradigm. We propose a closed-loop procedure, where the human learns how to improve the quality of the generated EMG signals, helping also to obtain a better controller. We apply it to 10 healthy and 3 limb-deficient subjects. Results show that the combination of the multidimensional targets and the open-loop training protocol significantly improve the performance, increasing the average completion rate from 53% to 65% for the most complicated case of simultaneously controlling the three degrees of freedom.

Digital contact tracing and network theory to stop the spread of COVID-19 using big-data on human mobility geolocalization.

The spread of COVID-19 caused by the SARS-CoV-2 virus has become a worldwide problem with devastating consequences. Here, we implement a comprehensive contact tracing and network analysis to find an optimized quarantine protocol to dismantle the chain of transmission of coronavirus with minimal disruptions to society. We track billions of anonymized GPS human mobility datapoints to monitor the evolution of the contact network of disease transmission before and after mass quarantines. As a consequence of the lockdowns, people's mobility decreases by 53%, which results in a drastic disintegration of the transmission network by 90%. However, this disintegration did not halt the spreading of the disease. Our analysis indicates that superspreading k-core structures persist in the transmission network to prolong the pandemic. Once the k-cores are identified, an optimized strategy to break the chain of transmission is to quarantine a minimal number of 'weak links' with high betweenness centrality connecting the large k-cores.

Adaptive Auto-Regressive Proportional Myoelectric Control.

In proportional myographic control, one can control either position or velocity of movement. Here, we propose to use adaptive auto-regressive filters, so as to gradually adjust between the two. We implemented this in an adaptive system with closed-loop feedback, where both the user and the machine simultaneously attempt to follow a cursor on a 2-D arena. We tested this on 15 able-bodied and three limb-deficient participants using an eight-channel myoelectric armband. The human-machine pairs learn to perform smoother cursor movements with a larger range of motion when using the auto-regressive filters, as compared with our previous effortswithmoving-average filters. Importantly, the human-machine system converges to an approximate velocity control strategy resulting in faster and more accuratemovements with lessmuscle effort. The method is not specific tomyoelectriccontroland could be used equally well for motion control using high-dimensional signals from reinnervatedmuscles or direct brain recordings.