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1.
TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules.
Mol Pharmacol
; 79(1): 34-41, 2011 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-20881006
2.
A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis.
Crit Care Med
; 38(8): 1685-94, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20562702
3.
Effect of Toll-like receptor 4 inhibitor on LPS-induced lung injury.
Inflamm Res
; 59(10): 837-45, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20387088
4.
TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain.
Eur J Pharmacol
; 584(1): 40-8, 2008 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-18299127
5.
Novel cyclohexene derivatives as anti-sepsis agents: synthetic studies and inhibition of NO and cytokine production.
Bioorg Med Chem
; 16(7): 3941-58, 2008 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18272372
6.
Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model.
Eur J Pharmacol
; 571(2-3): 231-9, 2007 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17632100
7.
Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate.
J Med Chem
; 48(23): 7457-67, 2005 Nov 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-16279805
8.
Combination of imipenem and TAK-242, a Toll-like receptor 4 signal transduction inhibitor, improves survival in a murine model of polymicrobial sepsis.
Shock
; 35(2): 205-9, 2011 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-20720515
9.
A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.
Mol Pharmacol
; 69(4): 1288-95, 2006 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-16373689
10.
NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway.
Infect Immun
; 74(4): 2121-7, 2006 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-16552041
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