Nanocarbon-based catalysts for selective nitroaromatic hydrogenation: A mini review.

Selective hydrogenation of nitroaromatics to the corresponding anilines is a key topic for research in fine chemical industrial fields. Nanocarbon materials with good chemical stability, high electrical conductivity, and good mechanical performance have been regarded as promising candidates in the catalytic field, and have shown a wide range of applications in recent years. Controllable synthesis on the structure, morphology, and active sites of nanocarbon-based catalysts is vital to the development of highly efficient catalysts. In this mini-review, we summarize the recent progresses of nanocarbon materials by focusing on the synthesis approaches and their corresponding nanostructures, including carbon nanofibers, carbon nanotubes, graphene, porous carbon, carbon spheres, and metal organic framework-derived carbon materials. The design and catalytic performance of these nanocarbon materials have been systematically discussed. Finally, the emerging challenges and future prospective for developing advanced nanocarbon-based catalysts are outlined.

Dipeptidyl Peptidase Inhibition Enhances CD8 T Cell Recruitment and Activates Intrahepatic Inflammasome in a Murine Model of Hepatocellular Carcinoma.

The mRNA expression of the dipeptidyl peptidase 4 (DPP4) gene family is highly upregulated in human hepatocellular carcinoma (HCC) and is associated with poor survival in HCC patients. Compounds that inhibit the DPP4 enzyme family, such as talabostat and ARI-4175, can mediate tumour regression by immune-mediated mechanisms that are believed to include NLRP1 activation. This study investigated the expression and activity of the DPP4 family during the development of HCC and evaluated the efficacy of ARI-4175 in the treatment of early HCC in mice. This first report on this enzyme family in HCC-bearing mice showed DPP9 upregulation in HCC, whereas intrahepatic DPP8/9 and DPP4 enzyme activity levels decreased with age. We demonstrated that ARI-4175 significantly lowered the total number of macroscopic liver nodules in these mice. In addition, ARI-4175 increased intrahepatic inflammatory cell infiltration, including CD8+ T cell numbers, into the HCC-bearing livers. Furthermore, ARI-4175 activated a critical component of the inflammasome pathway, caspase-1, in these HCC-bearing livers. This is the first evidence of caspase-1 activation by a pan-DPP inhibitor in the liver. Our data suggest that targeting the DPP4 enzyme family may be a novel and effective approach to promote anti-tumour immunity in HCC via caspase-1 activation.