1.
Bioorg Med Chem Lett
; 29(21): 126659, 2019 11 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-31543303
RESUMEN
Aided by Structure Based Drug Discovery (SBDD), we rapidly designed a highly novel and selective series of mTOR inhibitors. This chemotype conveys exquisite kinase selectivity, excellent in vitro and in vivo potencies and ADME safety profiles. These compounds could serve as good tools to explore the potential of TORC inhibition in various human diseases.