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1.
Impact of plastic-related compounds on the gene expression signature of HepG2 cells transfected with CYP3A4.
Arch Toxicol
; 98(2): 525-536, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38160208
2.
Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation.
Circ Res
; 129(8): 804-820, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34433292
3.
OCT1-dependent uptake of structurally diverse pyrrolizidine alkaloids in human liver cells is crucial for their genotoxic and cytotoxic effects.
Arch Toxicol
; 97(12): 3259-3271, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37676300
4.
Potency ranking of pyrrolizidine alkaloids in metabolically competent human liver cancer cells and primary human hepatocytes using a genotoxicity test battery.
Arch Toxicol
; 97(5): 1413-1428, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36928417
5.
The Effect of Plastic-Related Compounds on Transcriptome-Wide Gene Expression on CYP2C19-Overexpressing HepG2 Cells.
Molecules
; 28(16)2023 Aug 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37630204
6.
Alisertib shows negligible potential for perpetrating pharmacokinetic drug-drug interactions on ABCB1, ABCG2 and cytochromes P450, but acts as dual-activity resistance modulator through the inhibition of ABCC1 transporter.
Toxicol Appl Pharmacol
; 434: 115823, 2022 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34896433
7.
Pyrrolizidine alkaloids cause cell cycle and DNA damage repair defects as analyzed by transcriptomics in cytochrome P450 3A4-overexpressing HepG2 clone 9 cells.
Cell Biol Toxicol
; 38(2): 325-345, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33884520
8.
Metabolic Pattern of Hepatotoxic Pyrrolizidine Alkaloids in Liver Cells.
Chem Res Toxicol
; 34(4): 1101-1113, 2021 04 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-33719395
9.
Potential Effects of Nonadherent on Adherent Human Umbilical Venous Endothelial Cells in Cell Culture.
Int J Mol Sci
; 22(3)2021 Feb 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33540846
10.
Tepotinib Inhibits Several Drug Efflux Transporters and Biotransformation Enzymes: The Role in Drug-Drug Interactions and Targeting Cytostatic Resistance In Vitro and Ex Vivo.
Int J Mol Sci
; 22(21)2021 Nov 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34769363
11.
Structure-dependent genotoxic potencies of selected pyrrolizidine alkaloids in metabolically competent HepG2 cells.
Arch Toxicol
; 94(12): 4159-4172, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32910235
12.
Effect of Prostanoids on Human Platelet Function: An Overview.
Int J Mol Sci
; 21(23)2020 Nov 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-33260972
13.
Interactions of Alectinib with Human ATP-Binding Cassette Drug Efflux Transporters and Cytochrome P450 Biotransformation Enzymes: Effect on Pharmacokinetic Multidrug Resistance.
Drug Metab Dispos
; 47(7): 699-709, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31068367
14.
Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes.
Mol Pharm
; 16(11): 4436-4450, 2019 11 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31633365
15.
Primary-like human hepatocytes genetically engineered to obtain proliferation competence display hepatic differentiation characteristics in monolayer and organotypical spheroid cultures.
Cell Biol Int
; 40(3): 341-53, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26715207
16.
In vitro simulation of the liver first-pass effect with biotransformation-competent HepG2 cells to study effects of MG-132 on liver and cancer cells.
Clin Hemorheol Microcirc
; 86(1-2): 159-168, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-37638428
17.
Synthesis of mono Cytochrome P450 in a modified CHO-CPR cell-free protein production platform.
Sci Rep
; 14(1): 1271, 2024 01 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38218994
18.
Stable Chinese Hamster Ovary Suspension Cell Lines Harboring Recombinant Human Cytochrome P450 Oxidoreductase and Human Cytochrome P450 Monooxygenases as Platform for In Vitro Biotransformation Studies.
Cells
; 12(17)2023 08 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-37681872
19.
Anti-Cancer Prodrug Cyclophosphamide Exerts Thrombogenic Effects on Human Venous Endothelial Cells Independent of CYP450 Activation-Relevance to Thrombosis.
Cells
; 12(15)2023 07 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-37566045
20.
Investigation of Radiotracer Metabolic Stability In Vitro with CYP-Overexpressing Hepatoma Cell Lines.
Cells
; 11(15)2022 08 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35954291