1.
Chem Commun (Camb)
; 55(98): 14717-14720, 2019 Dec 05.
Artículo
en Inglés
| MEDLINE
| ID: mdl-31702759
RESUMEN
The final step in the biosynthesis of l-carnitine in humans is catalysed by the 2-oxoglutarate and ferrous iron dependent oxygenase, γ-butyrobetaine hydroxylase (BBOX). 1H and 19F NMR studies inform on the BBOX mechanism including by providing evidence for cooperativity between monomers in substrate/some inhibitor binding. The value of the 19F NMR methods is demonstrated by their use in the design of new BBOX inhibitors.