RESUMEN
There is limited district level data on drug or alcohol use as well as sex and reproductive history among secondary school students in Tanzania to inform prevention efforts. To address this, we conducted a survey of 2523 secondary school students in 2 districts (Bahi and Mpwapwa) and the Dodoma municipal area in Tanzania. Overall, fifty three percent were female and 67% were between the ages of 15 and 17 years old. Students in the Dodoma Municipality district self-reported the highest prevalence of forced sex, sex for gifts or money, and drug use. Students in the Bahi district reported the highest prevalence of alcohol use. Males reported a higher prevalence of consensual sex, contraception use, and alcohol and drug use compared to females, the latter of whom reported a higher prevalence of forced sex. Most students' indicated that their primary source of sex and reproductive health information was their teachers. These results suggest the need for tailored interventions among secondary school students in the Dodoma region in Tanzania.