Detalles de la búsqueda
1.
Debenzylative Cycloetherification as a Synthetic Tool in the Diastereoselective Synthesis of 3,6-Disubstituted Hexahydro-2H-furo[3,2-b]pyrroles, PDE1 Enzyme Inhibitors with an Antiproliferative Effect on Melanoma Cells.
J Org Chem
; 85(9): 5941-5951, 2020 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32248689
2.
Phosphodiesterase 1 Bridges Glutamate Inputs with NO- and Dopamine-Induced Cyclic Nucleotide Signals in the Striatum.
Cereb Cortex
; 29(12): 5022-5036, 2019 12 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-30877787
3.
Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT2A Receptor Agonist.
J Pharmacol Exp Ther
; 361(3): 441-453, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28360333
4.
In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1.
J Pharmacol Exp Ther
; 354(2): 166-74, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-25986445
5.
Correlating the metabolic stability of psychedelic 5-HT2A agonists with anecdotal reports of human oral bioavailability.
Neurochem Res
; 39(10): 2018-23, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24519542
6.
N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors.
Bioorg Med Chem
; 21(19): 6053-62, 2013 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23978358
7.
Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors.
Bioorg Med Chem Lett
; 21(12): 3738-42, 2011 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21602043
8.
Identification of a new series of non-peptidic NK3 receptor antagonists.
Bioorg Med Chem Lett
; 21(5): 1498-501, 2011 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21292483
9.
Synthesis and SAR study of new phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phosphodiesterase 10A inhibitors.
Bioorg Med Chem
; 19(1): 642-9, 2011 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21087867
10.
Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia.
Neuropharmacology
; 186: 108454, 2021 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33444639
11.
Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites.
J Med Chem
; 62(5): 2798-2813, 2019 03 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30763084
12.
4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships.
J Med Chem
; 50(8): 1988-92, 2007 Apr 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-17375905
13.
PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries.
Br J Pharmacol
; 174(22): 4186-4198, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28910498
14.
Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats.
Br J Pharmacol
; 174(15): 2563-2575, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28548283
15.
Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs.
J Med Chem
; 60(21): 9022-9039, 2017 11 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29028338
16.
5-HT2A/5-HT2C Receptor Pharmacology and Intrinsic Clearance of N-Benzylphenethylamines Modified at the Primary Site of Metabolism.
ACS Chem Neurosci
; 7(11): 1614-1619, 2016 11 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-27564969
17.
Discovery of α-Substituted Imidazole-4-acetic Acid Analogues as a Novel Class of ρ1 γ-Aminobutyric Acid Typeâ A Receptor Antagonists with Effect on Retinal Vascular Tone.
ChemMedChem
; 11(20): 2299-2310, 2016 10 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-27620323
18.
Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA(C) receptor antagonists.
Neurochem Int
; 42(7): 561-5, 2003 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-12590939
19.
Synthesis and SAR study of novel tricyclic pyrazoles as potent phosphodiesterase 10A inhibitors.
Eur J Med Chem
; 84: 181-93, 2014 Sep 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25016376
20.
From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group.
PLoS One
; 9(6): e100209, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24956197