Values for tissue magnesium as a guide in detecting magnesium deficiency.

A large-scale survey of the normal magnesium content of various human tissues was carried out to facilitate clinical detection of magnesium deficiency, especially occult deficiency.A review of the literature favours the magnesium content of skeletal muscle as the most reliable index of the body's store of magnesium. There is a significant difference (P < 0.001) in both the serum and erythrocyte magnesium levels between normal pregnant women in the third trimester and the average normal population. The reason for this difference is discussed.

The history of dialysis in Singapore.

The last 20 years has been seen the birth of nephrology in Singapore, starting from a single machine in a side room of a ward to a fully fledged unit with a satellite centre. Renal transplantation and hemodialysis have been accepted as a form of therapy for renal failure in Singapore. The spin off from the creation of dialysis units has been improvement in overall renal care particularly in cases of acute renal failure. It has also generated an atmosphere for research into renal diseases and has helped to promote the image of Singapore as a medical centre par excellence in Southeast Asia.

Nephrotic syndrome associated with malignant tumours.

The nephrotic syndrome complicating malignancy is an unusual occurrence. We report here four cases of nephrotic syndrome associated with malignant tumours. Three cases were associated with bronchogenic carcinoma and one with adenocarcinoma of colon. One of the four cases developed nephrotic syndrome before the discovery of bronchogenic carcinoma. All patients had renal biopsies with light microscopy, immunofluorescence and electron microscopy. The findings suggest an immune-complex disease complicating malignancy. The true incidence of nephrotic syndrome associated with malignant tumours is unknown. However it is clinically prudent to screen for malignancy in older patients presenting with nephrotic syndrome.