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1.

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice.

Saha, Asim; Palchaudhuri, Rahul; Lanieri, Leanne; Hyzy, Sharon; Riddle, Megan J; Panthera, Jamie; Eide, Cindy; Tolar, Jakub; Panoskaltsis-Mortari, Angela; Gorfinkel, Lev; Tkachev, Victor; Gerdemann, Ulrike; Alvarez-Calderon, Francesca; Palato, Elisa Rojas; MacMillan, Margaret L; Wagner, John E; Kean, Leslie S; Osborn, Mark; Kiem, Hans-Peter; Scadden, David T; Olson, Lisa M; Blazar, Bruce R.

Blood ; 2024 Mar 06.

Artículo en Inglés | MEDLINE | ID: mdl-38447038

2.

Stochastic fate decisions of HSCs after transplantation: early contribution, symmetric expansion, and pool formation.

Radtke, Stefan; Enstrom, Mark; Pande, Dnyanada; Duke, Elizabeth R; Cardozo-Ojeda, E Fabian; Madhu, Ravishankar; Owen, Staci; Kanestrom, Greta; Cui, Margaret; Perez, Anai M; Schiffer, Joshua T; Kiem, Hans-Peter.

Blood ; 142(1): 33-43, 2023 07 06.

Artículo en Inglés | MEDLINE | ID: mdl-36821766

3.

In vivo HSC prime editing rescues sickle cell disease in a mouse model.

Li, Chang; Georgakopoulou, Aphrodite; Newby, Gregory A; Chen, Peter J; Everette, Kelcee A; Paschoudi, Kiriaki; Vlachaki, Efthymia; Gil, Sucheol; Anderson, Anna K; Koob, Theodore; Huang, Lishan; Wang, Hongjie; Kiem, Hans-Peter; Liu, David R; Yannaki, Evangelia; Lieber, André.

Blood ; 141(17): 2085-2099, 2023 04 27.

Artículo en Inglés | MEDLINE | ID: mdl-36800642

4.

CD20 CAR T cells safely and reversibly ablate B cell follicles in a non-human primate model of HIV persistence.

Bui, John K; Starke, Carly E; Poole, Nikhita H; Rust, Blake J; Jerome, Keith R; Kiem, Hans-Peter; Peterson, Christopher W.

Mol Ther ; 32(5): 1238-1251, 2024 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-38414244

5.

Stem cell-derived CAR T cells show greater persistence, trafficking, and viral control compared to ex vivo transduced CAR T cells.

Carrillo, Mayra A; Zhen, Anjie; Mu, Wenli; Rezek, Valerie; Martin, Heather; Peterson, Christopher W; Kiem, Hans-Peter; Kitchen, Scott G.

Mol Ther ; 32(4): 1000-1015, 2024 Apr 03.

Artículo en Inglés | MEDLINE | ID: mdl-38414243

6.

A CD45-targeted antibody-drug conjugate successfully conditions for allogeneic hematopoietic stem cell transplantation in mice.

Saha, Asim; Hyzy, Sharon; Lamothe, Tahirih; Hammond, Katelyn; Clark, Nicholas; Lanieri, Leanne; Bhattarai, Prashant; Palchaudhuri, Rahul; Gillard, Geoffrey O; Proctor, Jennifer; Riddle, Megan J; Panoskaltsis-Mortari, Angela; MacMillan, Margaret L; Wagner, John E; Kiem, Hans-Peter; Olson, Lisa M; Blazar, Bruce R.

Blood ; 139(11): 1743-1759, 2022 03 17.

Artículo en Inglés | MEDLINE | ID: mdl-34986233

7.

CD90-targeted lentiviral vectors for HSC gene therapy.

Berckmueller, Kurt; Thomas, Justin; Taha, Eman A; Choo, Seunga; Madhu, Ravishankar; Kanestrom, Greta; Rupert, Peter B; Strong, Roland; Kiem, Hans-Peter; Radtke, Stefan.

Mol Ther ; 31(10): 2901-2913, 2023 10 04.

Artículo en Inglés | MEDLINE | ID: mdl-37550965

8.

Stable HIV decoy receptor expression after in vivo HSC transduction in mice and NHPs: Safety and efficacy in protection from SHIV.

Li, Chang; Anderson, Anna Kate; Wang, Hongjie; Gil, Sucheol; Kim, Jiho; Huang, Lishan; Germond, Audrey; Baldessari, Audrey; Nelson, Veronica; Bar, Katharine J; Peterson, Christopher W; Bui, John; Kiem, Hans-Peter; Lieber, André.

Mol Ther ; 31(4): 1059-1073, 2023 04 05.

Artículo en Inglés | MEDLINE | ID: mdl-36760126

9.

Replication competent retrovirus testing (RCR) in the National Gene Vector Biorepository: No evidence of RCR in 1,595 post-treatment peripheral blood samples obtained from 60 clinical trials.

Cornetta, Kenneth; Yao, Jing; House, Kimberley; Duffy, Lisa; Adusumilli, Prasad S; Beyer, Rachel; Booth, Claire; Brenner, Malcolm; Curran, Kevin; Grilley, Bambi; Heslop, Helen; Hinrichs, Christian S; Kaplan, Rosandra N; Kiem, Hans-Peter; Kochenderfer, James; Kohn, Donald B; Mailankody, Sham; Norberg, Scott M; O'Cearbhaill, Roisin E; Pappas, Jennifer; Park, Jae; Ramos, Carlos; Ribas, Antonio; Rivière, Isabelle; Rosenberg, Steven A; Sauter, Craig; Shah, Nirali N; Slovin, Susan F; Thrasher, Adrian; Williams, David A; Lin, Tsai-Yu.

Mol Ther ; 31(3): 801-809, 2023 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-36518078

10.

Factors associated with outcomes after a second CD19-targeted CAR T-cell infusion for refractory B-cell malignancies.

Gauthier, Jordan; Bezerra, Evandro D; Hirayama, Alexandre V; Fiorenza, Salvatore; Sheih, Alyssa; Chou, Cassie K; Kimble, Erik L; Pender, Barbara S; Hawkins, Reed M; Vakil, Aesha; Phi, Tinh-Doan; Steinmetz, Rachel N; Jamieson, Abby W; Bar, Merav; Cassaday, Ryan D; Chapuis, Aude G; Cowan, Andrew J; Green, Damian J; Kiem, Hans-Peter; Milano, Filippo; Shadman, Mazyar; Till, Brian G; Riddell, Stanley R; Maloney, David G; Turtle, Cameron J.

Blood ; 137(3): 323-335, 2021 01 21.

Artículo en Inglés | MEDLINE | ID: mdl-32967009

11.

Efficient polymer nanoparticle-mediated delivery of gene editing reagents into human hematopoietic stem and progenitor cells.

El-Kharrag, Rkia; Berckmueller, Kurt E; Madhu, Ravishankar; Cui, Margaret; Campoy, Gabriela; Mack, Heather M; Wolf, Carl B; Perez, Anai M; Humbert, Olivier; Kiem, Hans-Peter; Radtke, Stefan.

Mol Ther ; 30(6): 2186-2198, 2022 06 01.

Artículo en Inglés | MEDLINE | ID: mdl-35240320

12.

Extending Gene Medicines to All in Need.

McCune, Joseph M; Kiem, Hans-Peter.

N Engl J Med ; 390(18): 1721-1722, 2024 May 09.

Artículo en Inglés | MEDLINE | ID: mdl-38657269

13.

Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates.

Rust, Blake J; Kean, Leslie S; Colonna, Lucrezia; Brandenstein, Katherine E; Poole, Nikhita H; Obenza, Willimark; Enstrom, Mark R; Maldini, Colby R; Ellis, Gavin I; Fennessey, Christine M; Huang, Meei-Li; Keele, Brandon F; Jerome, Keith R; Riley, James L; Kiem, Hans-Peter; Peterson, Christopher W.

Blood ; 136(15): 1722-1734, 2020 10 08.

Artículo en Inglés | MEDLINE | ID: mdl-32614969

14.

Genome editing in large animal models.

Maynard, Lucy H; Humbert, Olivier; Peterson, Christopher W; Kiem, Hans-Peter.

Mol Ther ; 29(11): 3140-3152, 2021 11 03.

Artículo en Inglés | MEDLINE | ID: mdl-34601132

15.

CRISPR/Cas9 for the treatment of haematological diseases: a journey from bacteria to the bedside.

Humbert, Olivier; Samuelson, Clare; Kiem, Hans-Peter.

Br J Haematol ; 192(1): 33-49, 2021 01.

Artículo en Inglés | MEDLINE | ID: mdl-32506752

16.

Factors associated with durable EFS in adult B-cell ALL patients achieving MRD-negative CR after CD19 CAR T-cell therapy.

Hay, Kevin A; Gauthier, Jordan; Hirayama, Alexandre V; Voutsinas, Jenna M; Wu, Qian; Li, Daniel; Gooley, Ted A; Cherian, Sindhu; Chen, Xueyan; Pender, Barbara S; Hawkins, Reed M; Vakil, Aesha; Steinmetz, Rachel N; Schoch, Gary; Chapuis, Aude G; Till, Brian G; Kiem, Hans-Peter; Ramos, Jorge D; Shadman, Mazyar; Cassaday, Ryan D; Acharya, Utkarsh H; Riddell, Stanley R; Maloney, David G; Turtle, Cameron J.

Blood ; 133(15): 1652-1663, 2019 04 11.

Artículo en Inglés | MEDLINE | ID: mdl-30728140

17.

Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes.

Ozog, Stosh; Timberlake, Nina D; Hermann, Kip; Garijo, Olivia; Haworth, Kevin G; Shi, Guoli; Glinkerman, Christopher M; Schefter, Lauren E; D'Souza, Saritha; Simpson, Elizabeth; Sghia-Hughes, Gabriella; Carillo, Raymond R; Boger, Dale L; Kiem, Hans-Peter; Slukvin, Igor; Ryu, Byoung Y; Sorrentino, Brian P; Adair, Jennifer E; Snyder, Scott A; Compton, Alex A; Torbett, Bruce E.

Blood ; 134(16): 1298-1311, 2019 10 17.

Artículo en Inglés | MEDLINE | ID: mdl-31416800

18.

The response to lymphodepletion impacts PFS in patients with aggressive non-Hodgkin lymphoma treated with CD19 CAR T cells.

Hirayama, Alexandre V; Gauthier, Jordan; Hay, Kevin A; Voutsinas, Jenna M; Wu, Qian; Gooley, Ted; Li, Daniel; Cherian, Sindhu; Chen, Xueyan; Pender, Barbara S; Hawkins, Reed M; Vakil, Aesha; Steinmetz, Rachel N; Acharya, Utkarsh H; Cassaday, Ryan D; Chapuis, Aude G; Dhawale, Tejaswini M; Hendrie, Paul C; Kiem, Hans-Peter; Lynch, Ryan C; Ramos, Jorge; Shadman, Mazyar; Till, Brian G; Riddell, Stanley R; Maloney, David G; Turtle, Cameron J.

Blood ; 133(17): 1876-1887, 2019 04 25.

Artículo en Inglés | MEDLINE | ID: mdl-30782611

19.

TRAILshort Protects against CD4 T Cell Death during Acute HIV Infection.

Natesampillai, Sekar; Paim, Ana C; Cummins, Nathan W; Chandrasekar, Aswath P; Bren, Gary D; Lewin, Sharon R; Kiem, Hans-Peter; Badley, Andrew D.

J Immunol ; 203(3): 718-724, 2019 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-31189571

20.

HLA-Haploidentical Hematopoietic Cell Transplantation for Treatment of Nonmalignant Diseases Using Nonmyeloablative Conditioning and Post-Transplant Cyclophosphamide.

Mallhi, Kanwaldeep K; Srikanthan, Meera A; Baker, Kelsey K; Frangoul, Haydar A; Torgerson, Troy R; Petrovic, Aleksandra; Geddis, Amy E; Carpenter, Paul A; Baker, K Scott; Sandmaier, Brenda M; Thakar, Monica S; Skoda-Smith, Suzanne; Kiem, Hans-Peter; Storb, Rainer; Woolfrey, Ann E; Burroughs, Lauri M.

Biol Blood Marrow Transplant ; 26(7): 1332-1341, 2020 07.

Artículo en Inglés | MEDLINE | ID: mdl-32234377

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