Spectrally Resolved Exciton Polarizability for Understanding Charge Generation in Organic Bulk Hetero-Junction Diodes.

Despite decades of research, the dominant charge generation mechanism in organic bulk heterojunction (BHJ) devices is not completely understood. While the local dielectric environments of the photoexcited molecules are important for exciton dissociation, conventional characterizations cannot separately measure the polarizability of electron-donor and electron-acceptor, respectively, in their blends, making it difficult to decipher the spectrally different charge generation efficiencies in organic BHJ devices. Here, by spectrally resolved electroabsorption spectroscopy, we report extraction of the excited state polarizability for individual donors and acceptors in a series of organic blend films. Regardless of the donor and acceptor, we discovered that larger exciton polarizability is linked to larger π-π coherence length and faster charge transfer across the heterojunction, which fundamentally explains the origin of the higher charge generation efficiency near 100% in the BHJ photodiodes. We also show that the molecular packing of the donor and acceptor influence each other, resulting in a synergetic enhancement in the exciton polarizability.

Calibration of a multiview display with a tilted parallax barrier for reduction of nonlinear extrinsic crosstalk.

Multiview displays, which are capable of displaying different view-images for viewers at different positions, can suffer from undesirable view-image mixing, called crosstalk. In this paper, we propose a method to minimize a class of crosstalk that occurs due to misalignment of flat panel displays and parallax barriers that constitute multiview displays. More specifically, our method is aimed at cases where flat panel displays and parallax barriers are non-parallel. First, we introduce our framework, which associates homography matrices to sets of pixels visible through parallax barriers. Then, we propose an iterative method for finding pixels that are visible for a view-point. By using a stripe test pattern, the homography matrix that corresponds to a set of visible pixels can be found by monitoring the deformation of the stripe test pattern. Last, we experimentally check the validity of the iterative method and demonstrate that the proposed method successfully corrects the geometric distortion of a 3D image.

Dioscin-Mediated Autophagy Alleviates MPP+-Induced Neuronal Degeneration: An In Vitro Parkinson's Disease Model.

Autophagy is a cellular homeostatic process by which cells degrade and recycle their malfunctioned contents, and impairment in this process could lead to Parkinson's disease (PD) pathogenesis. Dioscin, a steroidal saponin, has induced autophagy in several cell lines and animal models. The role of dioscin-mediated autophagy in PD remains to be investigated. Therefore, this study aims to investigate the hypothesis that dioscin-regulated autophagy and autophagy-related (ATG) proteins could protect neuronal cells in PD via reducing apoptosis and enhancing neurogenesis. In this study, the 1-methyl-4-phenylpyridinium ion (MPP+) was used to induce neurotoxicity and impair autophagic flux in a human neuroblastoma cell line (SH-SY5Y). The result showed that dioscin pre-treatment counters MPP+-mediated autophagic flux impairment and alleviates MPP+-induced apoptosis by downregulating activated caspase-3 and BCL2 associated X, apoptosis regulator (Bax) expression while increasing B-cell lymphoma 2 (Bcl-2) expression. In addition, dioscin pre-treatment was found to increase neurotrophic factors and tyrosine hydroxylase expression, suggesting that dioscin could ameliorate MPP+-induced degeneration in dopaminergic neurons and benefit the PD model. To conclude, we showed dioscin's neuroprotective activity in neuronal SH-SY5Y cells might be partly related to its autophagy induction and suppression of the mitochondrial apoptosis pathway.

Mitigating Effect of Lindera obtusiloba Blume Extract on Neuroinflammation in Microglial Cells and Scopolamine-Induced Amnesia in Mice.

Lindera obtusiloba Blume (family, Lauraceae), native to Northeast Asia, has been used traditionally in the treatment of trauma and neuralgia. In this study, we investigated the neuroinflammatory effect of methanol extract of L. obtusiloba stem (LOS-ME) in a scopolamine-induced amnesia model and lipopolysaccharide (LPS)-stimulated BV2 microglia cells. LOS-ME downregulated the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, inflammatory cytokines, and inhibited the phosphorylation of nuclear factor kappa-B (NF-ĸB) and extracellular signal-regulated kinase (ERK) in LPS-stimulated BV2 cells. Male C57/BL6 mice were orally administered 20 and 200 mg/kg of LOS-ME for one week, and 2 mg/kg of scopolamine was administered intraperitoneally on the 8th day. In vivo behavioral experiments (Y-maze and Morris water maze test) confirmed that LOS-ME alleviated cognitive impairments induced by scopolamine and the amount of iNOS expression decreased in the hippocampus of the mouse brain. Microglial hyper-activation was also reduced by LOS-ME pretreatment. These findings suggest that LOS-ME might have potential in the treatment for cognitive improvement by regulating neuroinflammation.

A multicontrast imaging method using steady-state free precession with alternating RF flip angles.

PURPOSE: To obtain multicontrast images including fat-suppressed contrast image, a novel multicontrast imaging method using an SSFP sequence with alternating RF flip angles is proposed. METHODS: The proposed method uses the balanced SSFP sequence with 2 flip angles. In general, the conventional balanced SSFP sequence has its own unique contrast, which combines both FID signal and echo signal under a steady-state condition. By using alternating RF flip angles and RF phase cycling, various image contrasts weighted by proton density, T1 , and T2 can be obtained. The proposed method offers multicontrast images with fat suppression by using the combination of 2 images obtained just after alternating RF pulses, respectively. RESULTS: As demonstrated by simulations, phantom and in vivo experiments, the proposed method provides multicontrast knee images including fat-suppressed contrast images. CONCLUSION: The proposed method can be a useful tool for clinical diagnosis, such as the cartilage segmentation and the fast screening of lesions.

Iterative calibration of a multiview 3D display with linear extrinsic crosstalk using camera feedback.

In this paper, we propose a multiview 3D display calibration algorithm that compensates for misalignment between constituent layers. To minimize distortion of the 3D image due to misalignment, we employ an iterative algorithm using camera feedback. We first establish a mathematical model for the multiview display and predict distortion of a test image pattern due to misalignment. Then, we define two characteristic features of the feedback camera image that indicate the status of the alignment. Based on the mathematical model, we design a compensation algorithm that consists of cascaded one-dimensional root-finding blocks for two-dimensional optimization. Finally, we experimentally verify the image distortion model, convergence of the iterative algorithm, and image quality improvement. The accuracy of the proposed algorithm exceeds the required accuracy for linear extrinsic crosstalk compensation.

Critical nanofocusing of magnetic dipole moment using a closed plasmonic tip.

Squeezing magnetic dipole (MD) moment into a deep subwavelegnth apex of a tapered tip has not been achieved so far owing to a specific mode volume of a MD resonance which is dependent on an operating wavelength and back reflection of nanofocused waves. We propose a novel strategy for efficient delivery and nanofocusing of optical MD at an apex of a closed resonant plasmonic tip. Due to the ultracompact area (~λ2/900) of the nanocavity and resonances assisted by partial mirrors in a plasmonic waveguide, the enhancement factor of magnetic energy density is improved over 5 times. We expect that our scheme can help to investigate strong magnetic phenomena, including enhanced magnetic transition, artificial optical magnetism, multipole nonlinear optics, biomolecular sensing, magnetic near-field imaging, and spectroscopy.

Broadband ultrathin circular polarizer at visible and near-infrared wavelengths using a non-resonant characteristic in helically stacked nano-gratings.

Modern imaging and spectroscopy systems require to implement diverse functionalities with thin thickness and wide wavelength ranges. In order to meet this demand, polarization-resolved imaging has been widely investigated with integrated circular polarizers. However, the circular polarizers which operate at the entire visible wavelengths and have a thickness of several tens of nanometers have not been developed yet. Here, a circular polarizer, operating at the entire visible wavelength range, is demonstrated using helically stacked aluminum nano-grating layers. High extinction ratio and broad operation bandwidth are simultaneously achieved by using non-resonant anisotropic characteristics of the nano-grating. It is theoretically verified that the averaged extinction ratio becomes up to 8 over the entire visible wavelength range while having a thickness of 390 nm. Also, the feasibility of the proposed structure and circular polarization selectivity at the visible wavelength range are experimentally verified. It is expected that the proposed structure will lead to extreme miniaturization of a circular polarizer and contribute greatly to the development of mobile/wearable imaging systems such as virtual reality and augmented reality displays.

Regularized Huygens' plasmonic wave field synthesis using a metal-clad plasmonic waveguide array.

Huygens' principle states that point sources are the basis of optical wave field generation, and an array of point sources with complex amplitudes that are separated by subwavelength distances can generate a desired optical field distribution. In field synthesis based on the Huygens' principle, the construction of ideal point sources has been overlooked when compared to other elements in optical field synthesis engineering, such as complex modulation. However, the construction of ideal point sources should be considered an important goal because the use of non-ideal point sources generates considerable optical noise in the background of the synthesized field distribution. In this Letter, we investigate Huygens' plasmonic wave field synthesis and its regularization by analyzing the noise features that arise during wave field synthesis based on non-ideal point sources and proposing a novel structure for regularized point source construction. It is shown that the quality of plasmonic wave field synthesis based on the Huygens' principle is greatly improved with the proposed design of a structure that generates a unit point source. Practical field synthesis examples involving plasmonic focusing and Airy beams are presented in support of the proposed design.

Comparative Studies on Behavioral, Cognitive and Biomolecular Profiling of ICR, C57BL/6 and Its Sub-Strains Suitable for Scopolamine-Induced Amnesic Models.

Cognitive impairment and behavioral disparities are the distinctive baseline features to investigate in most animal models of neurodegenerative disease. However, neuronal complications are multifactorial and demand a suitable animal model to investigate their underlying basal mechanisms. By contrast, the numerous existing neurodegenerative studies have utilized various animal strains, leading to factual disparity. Choosing an optimal mouse strain for preliminary assessment of neuronal complications is therefore imperative. In this study, we systematically compared the behavioral, cognitive, cholinergic, and inflammatory impairments of outbred ICR and inbred C57BL/6 mice strains subject to scopolamine-induced amnesia. We then extended this study to the sub-strains C57BL/6N and C57BL/6J, where in addition to the above-mentioned parameters, their endogenous antioxidant levels and cAMP response-element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) protein expression were also evaluated. Compared with the ICR strain, the scopolamine-inflicted C57BL/6 strains exhibited a substantial reduction of spontaneous alternation and an approximately two-fold increase in inflammatory protein expression, compared to the control group. Among the sub-strains, scopolamine-treated C57BL/6N strains exhibited declined step-through latency, elevated acetylcholinesterase (AChE) activity and inflammatory protein expression, associated with reduced endogenous antioxidant levels and p-CREB/BDNF expression, compared to the control and tacrine-treated groups. This indicates that the C57BL/6N strains exhibit significantly enhanced scopolamine-induced neuronal impairment compared to the other evaluated strains.

In vitro assessment of cutting efficiency and durability of zirconia removal diamond rotary instruments.

STATEMENT OF PROBLEM: Recently, zirconia removal diamond rotary instruments have become commercially available for efficient cutting of zirconia. However, research of cutting efficiency and the cutting characteristics of zirconia removal diamond rotary instruments is limited. PURPOSE: The purpose of this in vitro study was to assess and compare the cutting efficiency, durability, and diamond rotary instrument wear pattern of zirconia diamond removal rotary instruments with those of conventional diamond rotary instruments. In addition, the surface characteristics of the cut zirconia were assessed. MATERIAL AND METHODS: Block specimens of 3 mol% yttrium cation-doped tetragonal zirconia polycrystal were machined 10 times for 1 minute each using a high-speed handpiece with 6 types of diamond rotary instrument from 2 manufacturers at a constant force of 2 N (n=5). An electronic scale was used to measure the lost weight after each cut in order to evaluate the cutting efficiency. Field emission scanning electron microscopy was used to evaluate diamond rotary instrument wear patterns and machined zirconia block surface characteristics. Data were statistically analyzed using the Kruskal-Wallis test, followed by the Mann-Whitney U test (α=.05). RESULTS: Zirconia removal fine grit diamond rotary instruments showed cutting efficiency that was reduced compared with conventional fine grit diamond rotary instruments. Diamond grit fracture was the most dominant diamond rotary instrument wear pattern in all groups. All machined zirconia surfaces were primarily subjected to plastic deformation, which is evidence of ductile cutting. Zirconia blocks machined with zirconia removal fine grit diamond rotary instruments showed the least incidence of surface flaws. CONCLUSIONS: Although zirconia removal diamond rotary instruments did not show improved cutting efficiency compared with conventional diamond rotary instruments, the machined zirconia surface showed smoother furrows of plastic deformation and fewer surface flaws.

Interferometric control of plasmonic resonator based on polarization-sensitive excitation of surface plasmon polaritons.

A plasmonic resonator is proposed whose electromagnetic energy density can be tuned by the polarization state of the incident light. Counter-propagating surface plasmon polaritons, which are excited by polarization-sensitive subwavelength apertures, give tunability. Stored energy density in the resonator varies from the minimum to the maximum when the orientation angle of the incoming electric field rotates by 90 degrees. After optimizing a rectangular cavity and periodic gratings, the on/off ratio is calculated as 430 and measured as 1.55. Based on our scheme, interferometric control is executed simply by rotation of a polarizer. The proposed plasmonic resonator can be utilized in all-optically controlled active plasmonic devices, coherent network elements, particle trapping systems, and polarimeters.

Scoparone Inhibits LPS-Simulated Inflammatory Response by Suppressing IRF3 and ERK in BV-2 Microglial Cells.

Microglia activation and the release of various inflammatory cytokines are largely related to neurological diseases, including Parkinson's, Alzheimer's, and other brain diseases. The suppression of microglial cells using natural bioactive compounds has become increasingly important for brain therapy owing to the expected beneficial effect of lower toxicity. Scoparone (6,7-dimethoxycoumarin), a major bioactive compound found in various plant parts, including the inner shell of chestnut (Castanea crenata), was evaluated on lipopolysaccharide (LPS)-activated BV-2 microglia cells. The results indicated that scoparone suppresses the LPS-stimulated increase of neuroinflammatory responses and inhibited the pro-inflammatory cytokine production in the BV-2 microglial cells. A mechanistic study showed that scoparone specifically inhibited the LPS-stimulated activation via a major regulation of IRF-3 and a regulation of ERK, whereby the phosphorylation in the BV-2 microglial cells is blocked. These data suggest that scoparone has anti-neuroinflammatory effects in LPS-activated BV-2 microglial cells, and could possibly be used in the development of novel drugs for the prevention and treatment of neuroinflammatory diseases.

Near-infrared coherent perfect absorption in plasmonic metal-insulator-metal waveguide.

We propose a design of ultra-compact plasmonic coherent perfect absorber (CPA) working in the near-infrared band. The main operating mechanism is the magnetic-dipole resonant coherent absorption in the metal-insulator-metal waveguide, which enables the CPA in the near-infrared band and can be also flexibly adjusted to place the magnetic-dipole resonance at any position in the near-infrared band. Numerical analysis verifies our proposal that the magnetic resonant CPA is crucial for near-IR CPA in the ultra-compact metal-insulator-metal waveguide.

Reflectionless compact plasmonic waveguide mode converter by using a mode-selective cavity.

A compact transmissive plasmonic waveguide mode converter which aims for the elimination of reflection and transmission of unconverted mode is proposed. The proposed scheme exploits a cavity formed by mode selective mirrors, which only allows two output modes: the transmission of the target mode and the reflection of the input mode. By appropriately tuning cavity lengths, the reflection of the input mode can also be suppressed to near zero by destructive interference, thereby all the residual outgoing modes are suppressed. The proposed device might be useful in the design of integrated photonic system since it relaxes the problem of unwanted reflection.

Tunable asymmetric mode conversion using the dark-mode of three-mode waveguide system.

A design scheme for low-reflection asymmetric mode conversion structure in three-mode waveguide system is proposed. By using a dark-mode of three-mode system, which can be interpreted in terms of destructive interference of transition amplitudes, the transmission characteristics for forward and backward directions can be designed separately. After explanation of the proposed design scheme, we demonstrate an example of asymmetric mode converter that consists of two gratings. The proposed scheme may be useful for the design of tunable asymmetric transmission devices due to its design flexibility and efficient design process.

Slow surface plasmon pulse excitation in metal-insulator-metal plasmonic waveguide with chirped grating.

A scheme for the excitation of slow surface plasmon pulses using photonic interband transition in a metal-insulator-metal (MIM) waveguide is proposed. An investigation the mode transition behavior inside the binary grating confirmed that the proposed concept can be understood in terms of the coupling of symmetric and anti-symmetric plasmonic modes. We observed that, although a binary grating that is optimized for a single frequency can excite slow surface plasmon pulses, it is inadequate for broadband mode conversion. To rectify this, a chirped grating was designed for the demonstration of broadband mode conversion by applying a cascade mode transition with different frequencies.