RESUMEN
Polar mesosphere winter echoes (PMWE) were observed at 70 km over Tromsø, Norway, on 8 January 2014 using the tristatic configuration of the European incoherent scatter VHF radar. For the interval 11:00-13:00 UT where the strongest patch of PMWE of about 6-min duration was detected, the spectra of the received signal were analysed for the Tromsø site and altitude profiles of spectral parameters were derived. For the remote sites Kiruna and Sodankylä, the Doppler velocities and their vertical shear were determined by using the measured autocorrelation functions. Ducted gravity waves with periods of 5-10 min were found in the vertical wind velocity between 66 and 81 km altitudes. The duct might be formed around 70 and 77 km altitude where horizontal wind maxima were observed with the Kiruna receiver. However, we did not find any close relation between wind shear at 70 km altitude and PMWE at the same height: the wind shear was present for 2 h, but PMWE for only 6 min. Enhanced spectral width in the vertical Tromsø beam was observed for the PMWE patch. We discussed these experimental findings in relation to the winter echo generation mechanism. Our conclusion is that the presence of patchy negatively charged small-sized dust might explain the observations although a gravity wave breaking mechanism cannot be completely rejected.
RESUMEN
Enzymes used in cleaning products have an excellent safety profile, with little ability to cause adverse responses in humans. For acute toxicity, genotoxicity, sub-acute and repeated dose toxicity, enzymes are unremarkable. Reproductive toxicity and carcinogenicity are also not endpoints of concern. Exceptions are the ability of some proteases to produce irritating effects at high concentrations and more importantly, the intrinsic potential of these bacterial/fungal proteins to act as respiratory sensitizers. It is a reasonable assumption that the majority of enzyme proteins possess this hazard. However, methods for characterising the respiratory sensitisation hazard of enzymes are lacking and the information required for risk assessment and risk management, although sufficient, remains limited. Previously, most data was generated in animal models and in in vitro immunoassays that assess immunological cross-reactivity. Nevertheless, by the establishment of strict limits on airborne exposure (based on a defined minimal effect limit of 60ng active enzyme protein/m(3)) and air and health monitoring, occupational safety can be assured. Similarly, by ensuring that airborne exposure is kept similarly low, coupled with knowledge of the fate of these enzymes on skin and fabrics, it has proven possible to establish a long history of safe consumer use of enzyme containing products.