Hemorrhagic unilateral retinopathy.

PURPOSE: To evaluate the possible etiologies of a hemorrhagic unilateral retinopathy in healthy patients. METHODS: Retrospective case series and review of the literature. All patients underwent a detailed ophthalmologic evaluation and analyses of their medical histories. RESULTS: Eleven eyes of 10 patients with unexplained unilateral, predominantly deep, intraretinal hemorrhages were identified. All patients were women. Mean age of the subjects was 48.4 years (range, 25-83 years). The main complaint at presentation was sudden visual loss, with visual acuity ranging from 20/20 to hand motion. The mean follow-up was 17 months, and the 9 eyes with follow-up showed spontaneous resolution of the hemorrhages and marked improvement of vision. There was no history of Valsalva maneuver or strenuous exercise. The patients were healthy at presentation and during follow-ups as long as 84 months. CONCLUSION: This series depicts the characteristics of a possible new entity with a review of the differential diagnosis. The visual outcome was excellent.

Immediate hyphema after intravitreal injections of ranibizumab.

PURPOSE: To report two cases of immediate hyphema formation after the intravitreal injection of ranibizumab. METHODS: Retrospective case reports. RESULTS: A patient with choroidal neovascularization caused by exudative age-related macular degeneration and a patient with cystoid macular edema caused by branch retinal vein occlusion underwent an intravitreal injection of 0.5 mg/0.05 mL of ranibizumab. The development of hyphema was seen immediately after the intravitreal injection in both cases. One patient was pseudophakic, taking 325 mg of aspirin daily. The other patient was phakic without any anticoagulation history. CONCLUSION: To the best of our knowledge, this is the third report of the development of hyphema associated with intravitreal injections.