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1.
Hum Factors ; 65(3): 419-434, 2023 05.
Artículo en Inglés | MEDLINE | ID: mdl-34148475

RESUMEN

OBJECTIVE: This prospective study assessed the risk of developing rotator cuff syndrome (RCS) with separate or specific combinations of biomechanical exposures measures, controlling for individual confounders. BACKGROUND: Compared with other musculoskeletal disorders, rates of work-related shoulder musculoskeletal disorders have been declining more slowly. METHOD: We conducted up to 2 years of individual, annual assessments of covariates, exposures, and health outcomes for 393 U.S. manufacturing and healthcare workers without RCS at baseline. Task-level biomechanical exposures assessed exposure to forceful exertions (level, exertion rates, duty cycles), vibration, and upper arm postures (flexion, abduction). Hazard ratios (HRs) were calculated with Cox proportional hazard models. RESULTS: We observed 39 incident RCS cases in 694 person-years (incidence rate = 5.62 per 100 person-years). Adjusting for confounders, we found increased risk of incident RCS associated with forceful hand exertions per minute for three upper arm posture tertiles: flexion ≥45° (≥28.2% time, HR = 1.11, CI [1.01, 1.22]), abduction ≥30° (11.9-21.2%-time, HR = 1.18, CI [1.04, 1.34]), and abduction >60° (≥4.8% time, HR = 1.16, CI [1.04, 1.29]). We failed to observe statistically significant effects for other interactions or any separate measures of biomechanical exposure. CONCLUSION: This study highlights the importance of assessing combinations of exposure to forceful repetition and upper arm elevation when developing interventions for preventing RCS. APPLICATION: Based on these results, interventions that reduce exposure to forceful repetition (i.e., lower force levels and/or slower exertion rates) may reduce the risk of RCS, especially when upper arm elevation cannot be avoided.


Asunto(s)
Enfermedades Musculoesqueléticas , Enfermedades Profesionales , Humanos , Manguito de los Rotadores , Estudios Prospectivos , Enfermedades Profesionales/epidemiología , Enfermedades Profesionales/etiología , Factores de Riesgo , Personal de Salud
2.
J Oncol Pharm Pract ; 25(5): 1152-1159, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-29950149

RESUMEN

OBJECTIVES: In order to produce near real-time onsite results to detect surface contamination by antineoplastic drugs, the National Institute for Occupational Safety and Health developed monitors for 5-fluorouracil, which use surface wiping and lateral flow immunoassay for measurement. The monitors were tested in the laboratory to assess the sensitivity of detection on laboratory-produced contaminated surfaces. A field evaluation to assess the capability of the monitors to make measurements in healthcare workplaces was carried out in collaboration with a medical device company and the results are presented in this report. METHODS: The 5-fluorouracil monitor was evaluated in areas where oncology drugs were prepared and administered to patients at five different hospitals. The levels of contamination measured with the monitors were compared to levels measured with liquid chromatography-tandem mass spectrometry. RESULTS: The 5-fluorouracil values measured with the liquid chromatography-tandem mass spectrometry ranged from 0 to over 200,000 ng/100 cm2. Measurements by the 5-fluorouracil monitors in the range 10-100 ng/100 cm2 correlated with the liquid chromatography-tandem mass spectrometry. Receiver operating characteristic curves developed for the data indicated that a positive limit of 22 ng/100 cm2 would give an acceptable level of false-positives while retaining most true-positive samples. If the liquid chromatography-tandem mass spectrometry measured greater than 100 ng/100 cm2, then the monitors also measured levels greater than 100 ng/100 cm2 for the majority of samples. CONCLUSION: The data indicate that there are many areas in hospitals that are contaminated with 5-fluorouracil and the monitors will be useful in identifying this contamination.


Asunto(s)
Antineoplásicos/análisis , Contaminación de Equipos , Fluorouracilo/análisis , Exposición Profesional/análisis , Antineoplásicos/química , Cromatografía Liquida/métodos , Hospitales , Humanos , Salud Laboral , Lugar de Trabajo
3.
Int J Audiol ; 58(8): 484-496, 2019 08.
Artículo en Inglés | MEDLINE | ID: mdl-31017499

RESUMEN

Objective: To examine the auditory system of Brazilian gasoline station workers using an extensive audiological test battery. Design: This was a cross-sectional study. The audiological evaluation included a questionnaire, pure-tone audiometry, acoustic immittance tests, transient-evoked otoacoustic emissions (TEOAEs), distortion product otoacoustic emissions (DPOAEs), auditory brainstem response (ABR) and P300 auditory-evoked potentials. Study sample: A total of 77 Brazilian gasoline station workers were evaluated, and their results were compared with those of 36 participants who were not exposed to chemicals or noise at work. The gasoline station employees worked in 18 different gas stations, and the noise area measurements from all gas stations revealed time-weighted averages below 85 dBA. Results: Of the 77 gasoline station workers evaluated, 67.5% had audiometric results within the normal range, but 59.7% reported difficulties in communication in noisy places. Gasoline station workers showed significantly poorer results than non-exposed control participants in one or more conditions of each of the audiological tests used, except P300. Conclusions: The results suggest that the gasoline station workers have both peripheral and central auditory dysfunctions that could be partly explained by their exposure to gasoline.


Asunto(s)
Vías Auditivas/fisiopatología , Percepción Auditiva , Gasolina/efectos adversos , Trastornos de la Audición/etiología , Pérdida Auditiva Provocada por Ruido/etiología , Audición , Exposición Profesional/efectos adversos , Adulto , Anciano , Audiometría de Tonos Puros , Umbral Auditivo , Brasil , Estudios Transversales , Potenciales Relacionados con Evento P300 , Potenciales Evocados Auditivos del Tronco Encefálico , Femenino , Trastornos de la Audición/diagnóstico , Trastornos de la Audición/fisiopatología , Trastornos de la Audición/psicología , Pérdida Auditiva Provocada por Ruido/diagnóstico , Pérdida Auditiva Provocada por Ruido/fisiopatología , Pérdida Auditiva Provocada por Ruido/psicología , Humanos , Masculino , Persona de Mediana Edad , Ruido/efectos adversos , Enfermedades Profesionales/etiología , Enfermedades Profesionales/fisiopatología , Enfermedades Profesionales/psicología , Salud Laboral , Emisiones Otoacústicas Espontáneas , Medición de Riesgo , Factores de Riesgo , Adulto Joven
4.
J Occup Environ Hyg ; 16(12): 775-784, 2019 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-31658434

RESUMEN

Wildland firefighters are exposed to numerous noise sources that may be hazardous to their hearing. This study examined the noise exposure profiles for 264 wildland firefighters across 15 job categories. All 264 firefighters completed questionnaires to assess their use of hearing protection devices, enrollment in hearing conservation programs, and their overall perception of their noise exposure. Roughly 54% of firefighters' noise exposures exceeded the National Institute for Occupational Safety and Health recommended exposure limit of 85 decibels, A-weighted, over 8 hr, and 32% exceeded the Occupational Safety and Health Administration permissible exposure limit of 90 decibels, A-weighted, over 8 hr. Questionnaire results indicated good agreement between noise exposures and firefighters' perceptions of the noise hazard. Approximately 65% reported that they used some form of hearing protection; however, only 19% reported receiving any proper training regarding the use of hearing protection devices, with the majority of those firefighters relying on earplugs, including electronic and level-dependent earplugs, over earmuffs or other forms of hearing protectors. The results also suggest that improved communication and situational awareness play a greater role in the consistent use of hearing protection devices than other factors such as risk of developing noise-induced hearing loss. The study highlighted the challenges facing wildland firefighters and their management and the need for a comprehensive wildland fire agencies' hearing conservation program especially for firefighters who were exempt based on their occupational designations.


Asunto(s)
Bomberos/psicología , Pérdida Auditiva Provocada por Ruido/prevención & control , Ruido en el Ambiente de Trabajo/efectos adversos , Enfermedades Profesionales/prevención & control , Exposición Profesional/prevención & control , Adulto , Anciano , Dispositivos de Protección de los Oídos/estadística & datos numéricos , Femenino , Bomberos/estadística & datos numéricos , Bosques , Conocimientos, Actitudes y Práctica en Salud , Pérdida Auditiva Provocada por Ruido/etiología , Pérdida Auditiva Provocada por Ruido/psicología , Humanos , Masculino , Persona de Mediana Edad , Enfermedades Profesionales/etiología , Enfermedades Profesionales/psicología , Exposición Profesional/análisis , Percepción , Encuestas y Cuestionarios , Estados Unidos , Adulto Joven
5.
J Occup Environ Hyg ; 14(4): 294-305, 2017 04.
Artículo en Inglés | MEDLINE | ID: mdl-27786602

RESUMEN

The National Institute for Occupational Safety and Health (NIOSH) sponsored tests of three earplug fit-test systems (NIOSH HPD Well-Fit, Michael & Associates FitCheck, and Honeywell Safety Products VeriPRO). Each system was compared to laboratory-based real-ear attenuation at threshold (REAT) measurements in a sound field according to ANSI/ASA S12.6-2008 at the NIOSH, Honeywell Safety Products, and Michael & Associates testing laboratories. An identical study was conducted independently at the U.S. Army Aeromedical Research Laboratory (USAARL), which provided their data for inclusion in this article. The Howard Leight Airsoft premolded earplug was tested with twenty subjects at each of the four participating laboratories. The occluded fit of the earplug was maintained during testing with a soundfield-based laboratory REAT system as well as all three headphone-based fit-test systems. The Michael & Associates lab had the highest average A-weighted attenuations and smallest standard deviations. The NIOSH lab had the lowest average attenuations and the largest standard deviations. Differences in octave-band attenuations between each fit-test system and the American National Standards Institute (ANSI) sound field method were calculated (Attenfit-test - AttenANSI). A-weighted attenuations measured with FitCheck and HPD Well-Fit systems demonstrated approximately ±2 dB agreement with the ANSI sound field method, but A-weighted attenuations measured with the VeriPRO system underestimated the ANSI laboratory attenuations. For each of the fit-test systems, the average A-weighted attenuation across the four laboratories was not significantly greater than the average of the ANSI sound field method. Standard deviations for residual attenuation differences were about ±2 dB for FitCheck and HPD Well-Fit compared to ±4 dB for VeriPRO. Individual labs exhibited a range of agreement from less than a dB to as much as 9.4 dB difference with ANSI and REAT estimates. Factors such as the experience of study participants and test administrators, and the fit-test psychometric tasks are suggested as possible contributors to the observed results.


Asunto(s)
Dispositivos de Protección de los Oídos , Pérdida Auditiva Provocada por Ruido/prevención & control , Humanos , National Institute for Occupational Safety and Health, U.S. , Reproducibilidad de los Resultados , Estados Unidos
6.
Am J Ind Med ; 59(7): 583-90, 2016 07.
Artículo en Inglés | MEDLINE | ID: mdl-27094769

RESUMEN

INTRODUCTION: Investigations of the effects of occupational exposure to lead on the concentrations of thyroid hormones in the blood have not produced consistent results. A meta-analysis was performed to assess the effect of occupational exposure to lead on thyroid hormone concentrations using the results from published studies. METHODS: Group means from studies of the thyroid function of persons occupationally exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between thyroid hormone concentrations and log10 blood lead concentrations or duration of exposure to lead were estimated using mixed models. The hormones analyzed were thyroid stimulating hormone, total and free thyroxine, and total and free triiodothyronine. RESULTS: No differences in mean thyroid hormone concentrations were found between the exposed and control groups. No relationships were found between blood lead or the duration of exposure to lead and thyroid hormone concentrations. CONCLUSION: The results of the analysis do not provide evidence for an effect of occupational lead exposure on thyroid function in men. Am. J. Ind. Med. 59:583-590, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.


Asunto(s)
Plomo/sangre , Exposición Profesional/análisis , Hormonas Tiroideas/sangre , Adulto , Humanos , Plomo/análisis , Exposición Profesional/efectos adversos
7.
Am J Ind Med ; 59(2): 164-74, 2016 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-26725335

RESUMEN

BACKGROUND: This article examines serious and fatal pneumatic nail gun (PNG) injury investigations for workplace, tool design, and human factors relevant to causation and resulting OS&H authorities' responses in terms of citations and penalties. METHODS: The U.S. Occupational Safety and Health Administration (OSHA) database of Fatality and Catastrophe Investigation Summaries (F&CIS) were reviewed (1985-2012) to identify n = 258 PNG accidents. RESULTS: 79.8% of investigations, and 100% of fatalities, occurred in the construction industry. Between 53-71% of injuries appear to have been preventable had a safer sequential trigger tool been used. Citations and monetary penalties were related to injury severity, body part injured, disabling of safety devices, and insufficient personal protective equipment (PPE). CONCLUSIONS: Differences may exist between construction and other industries in investigators interpretations of PNG injury causation and resulting citations/penalties. Violations of PPE standards were penalized most severely, yet the preventive effect of PPE would likely have been less than that of a safer sequential trigger.


Asunto(s)
Industria de la Construcción/estadística & datos numéricos , Materiales de Construcción/efectos adversos , Falla de Equipo/estadística & datos numéricos , Salud Laboral/estadística & datos numéricos , Traumatismos Ocupacionales/mortalidad , Industria de la Construcción/normas , Diseño de Equipo , Seguridad de Equipos/normas , Seguridad de Equipos/estadística & datos numéricos , Armas de Fuego , Humanos , Salud Laboral/normas , Traumatismos Ocupacionales/etiología , Equipo de Protección Personal/estadística & datos numéricos , Estados Unidos/epidemiología , United States Occupational Safety and Health Administration/normas , United States Occupational Safety and Health Administration/estadística & datos numéricos
8.
Reprod Biomed Online ; 30(2): 150-6, 2015 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-25498592

RESUMEN

The aim of this prospective cohort study was to determine the time-course in androgen and semen parameters in men after weight loss associated with bariatric surgery. Six men aged 18-40 years, meeting National Institutes of Health bariatric surgery guidelines, were followed between 2005 and 2008. Study visits took place at baseline, then 1, 3, 6 and 12 months after surgery. All men underwent Roux-en-y gastric bypass (RYGB). At each visit, biometric, questionnaire, serum, and urinary specimens and seman analysis were collected. Urinary integrated total testosterone levels increased significantly (P < 0.0001) by 3 months after surgery, and remained elevated throughout the study. Circulating testosterone levels were also higher at 1 and 6 months after surgery, compared with baseline. Serum sex hormone-binding globulin levels were significantly elevated at all time points after surgery (P < 0.01 to P = 0.02). After RYGB surgery, no significant changes occurred in urinary oestrogen metabolites (oestrone 3-glucuronide), serum oestradiol levels, serial semen parameters or male sexual function by questionnaire. A threshold of weight loss is necessary to improve male reproductive function by reversing male hypogonadism, manifested as increased testosterone levels. Further serial semen analyses showed normal ranges for most parameters despite massive weight loss.


Asunto(s)
Derivación Gástrica , Semen/metabolismo , Testosterona/orina , Adolescente , Adulto , Estradiol/sangre , Estrógenos/química , Estrona/análogos & derivados , Estrona/química , Humanos , Infertilidad Masculina/complicaciones , Masculino , Obesidad/complicaciones , Obesidad/cirugía , Estudios Prospectivos , Globulina de Unión a Hormona Sexual/metabolismo , Encuestas y Cuestionarios , Factores de Tiempo , Resultado del Tratamiento , Pérdida de Peso , Adulto Joven
9.
Environ Res ; 121: 84-94, 2013 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-23194642

RESUMEN

BACKGROUND: For 15 months in 1981-1982, the commercial milk supply on the Hawaiian island of Oahu was contaminated with heptachlor epoxide, a metabolite of the insecticide heptachlor, resulting in gestational and/or lactational exposure to offspring of women who drank cow milk during that period. OBJECTIVE: To determine whether gestational and lactational exposure to heptachlor epoxide alters reproductive function and age at puberty in men or women. METHODS: 457 participants were recruited from a prior high school enrollment sampling frame of 20,000 adults born during 1981-1982 who lived on Oahu since at least first grade. Number of glasses of cow milk consumed weekly by the mother during the participant's gestation was used as a surrogate measure of heptachlor epoxide exposure. Reproductive function measures included semen analyses; reproductive hormones or their metabolites in daily urine specimens for one menstrual cycle; serum reproductive hormone levels in both sexes; and reported ages of onset for pubertal milestones. RESULTS: We observed no strong associations of heptachlor epoxide exposure during gestation and lactation with reproductive endpoints. In females, heptachlor epoxide exposure was associated with longer luteal phase length and slower drop in the ratio of estradiol to progesterone metabolites after ovulation. In males, heptachlor epoxide exposure was weakly associated with higher serum follicle stimulating hormone and luteinizing hormone concentrations, but no dose-response relationship was apparent. CONCLUSIONS: The results provide limited evidence that gestational and lactational exposure to heptachlor epoxide, due to milk contamination on Oahu in 1981-1982, resulted in clinically significant disturbances of reproductive function in men or women.


Asunto(s)
Contaminación de Alimentos , Epóxido de Heptaclor/toxicidad , Efectos Tardíos de la Exposición Prenatal , Pubertad/efectos de los fármacos , Espermatozoides/efectos de los fármacos , Adolescente , Adulto , Factores de Edad , Animales , Niño , Relación Dosis-Respuesta a Droga , Estradiol/sangre , Femenino , Hormona Folículo Estimulante/orina , Hawaii , Humanos , Lactancia , Fase Luteínica/efectos de los fármacos , Masculino , Exposición Materna , Leche/química , Leche Humana/química , Ovulación , Embarazo , Progesterona/sangre
10.
Semin Hear ; 44(4): 485-502, 2023 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-37818145

RESUMEN

The National Institute for Occupational Safety and Health (NIOSH) evaluated continuous and impact noise exposures and hearing loss among workers at a hammer forge company. Full-shift personal noise exposure measurements were collected on forge workers across 15 different job titles; impact noise characteristics and one-third octave band noise levels were assessed at the forge hammers; and 4,750 historic audiometric test records for 483 workers were evaluated for hearing loss trends. Nearly all workers' noise exposures exceeded regulatory and/or recommended exposure limits. Workers working in jobs at or near the hammers had full-shift time-weighted average noise exposures above 100 decibels, A-weighted. Impact noise at the hammers reached up to 148 decibels. Analysis of audiometric test records showed that 82% of workers had experienced a significant threshold shift, as defined by NIOSH, and 63% had experienced a standard threshold shift, as defined by the Occupational Safety and Health Administration (OSHA). All workers with an OSHA standard threshold shift had a preceding NIOSH significant threshold shift which occurred, on average, about 7 years prior. This evaluation highlights forge workers' exposures to high levels of noise, including impact noise, and how their hearing worsened with age and length of employment.

11.
Mutat Res ; 747(2): 218-27, 2012 Sep 18.
Artículo en Inglés | MEDLINE | ID: mdl-22617435

RESUMEN

The genotoxicity of jet propulsion fuel 8 (JP-8) was assessed in the leukocytes of archived blood specimens from U.S. Air Force personnel using the comet assay. No differences in mean comet assay measurements were found between low, moderate, and high exposure groups before or after a 4h work shift. Before the work shift, mean tail DNA and mean tail (Olive) moment increased as the concentration of benzene measured in end-exhaled breath increased, indicating that prior environmental or work-related exposures to benzene produced DNA damage. The number of cells with highly damaged DNA decreased as the pre-shift benzene concentration in breath increased. It is not clear why the decrease is occurring. Mean tail DNA and mean tail (Olive) moment decreased as the concentrations of benzene and naphthalene measured in breath immediately after the work shift increased. These inverse relationships may reflect a slower rate of absorption or a faster rate of expiration of benzene in the lung. The number of cells with highly damaged DNA increased as the concentration of urinary (2-methoxyethoxy)acetic acid (MEAA) increased. This relationship was not seen in urinary MEAA adjusted for creatinine. MEAA is a metabolite of the deicing agent 2-(2-methoxyethoxy)ethanol contained in JP-8. MEAA or a component of JP-8 correlated with MEAA may have a toxic effect on DNA.


Asunto(s)
Contaminantes Ocupacionales del Aire/toxicidad , Daño del ADN , Hidrocarburos/toxicidad , Mutágenos/toxicidad , Acetatos/orina , Adulto , Benceno/análisis , Pruebas Respiratorias , Ensayo Cometa , Femenino , Humanos , Masculino , Personal Militar , Naftalenos/análisis , Exposición Profesional , Adulto Joven
12.
J Toxicol Environ Health A ; 75(11): 661-72, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-22712851

RESUMEN

A study of workers exposed to jet fuel propellant 8 (JP-8) was conducted at U.S. Air Force bases and included the evaluation of three biomarkers of exposure: S-benzylmercapturic acid (BMA), S-phenylmercapturic acid (PMA), and (2-methoxyethoxy)acetic acid (MEAA). Postshift urine specimens were collected from various personnel categorized as high (n = 98), moderate (n = 38) and low (n = 61) JP-8 exposure based on work activities. BMA and PMA urinary levels were determined by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), and MEAA urinary levels were determined by gas chromatography-mass spectrometry (GC-MS). The numbers of samples determined as positive for the presence of the BMA biomarker (above the test method's limit of detection [LOD = 0.5 ng/ml]) were 96 (98.0%), 37 (97.4%), and 58 (95.1%) for the high, moderate, and low (control) exposure workgroup categories, respectively. The numbers of samples determined as positive for the presence of the PMA biomarker (LOD = 0.5 ng/ml) were 33 (33.7%), 9 (23.7%), and 12 (19.7%) for the high, moderate, and low exposure categories. The numbers of samples determined as positive for the presence of the MEAA biomarker (LOD = 0.1 µ g/ml) were 92 (93.4%), 13 (34.2%), and 2 (3.3%) for the high, moderate, and low exposure categories. Statistical analysis of the mean levels of the analytes demonstrated MEAA to be the most accurate or appropriate biomarker for JP-8 exposure using urinary concentrations either adjusted or not adjusted for creatinine; mean levels of BMA and PMA were not statistically significant between workgroup categories after adjusting for creatinine.


Asunto(s)
Acetatos/orina , Hidrocarburos/farmacocinética , Personal Militar , Exposición Profesional , Petróleo/metabolismo , Urinálisis/métodos , Acetilcisteína/análogos & derivados , Acetilcisteína/orina , Adulto , Aeropuertos , Biomarcadores/orina , Cromatografía Líquida de Alta Presión , Creatinina/orina , Relación Dosis-Respuesta a Droga , Cromatografía de Gases y Espectrometría de Masas , Humanos , Hidrocarburos/administración & dosificación , Límite de Detección , Instalaciones Militares , Espectrometría de Masas en Tándem , Estados Unidos
13.
Int Arch Occup Environ Health ; 85(4): 413-20, 2012 May.
Artículo en Inglés | MEDLINE | ID: mdl-21809101

RESUMEN

PURPOSE: To demonstrate the utility of the urinary metabolite (2-methoxyethoxy)acetic acid (MEAA) as a biomarker of exposure. 2-(2-methoxyethoxy)ethanol [diethylene glycol monomethyl ether] is an anti-icing agent used in the formulation of JP-8, and it is added at a known uniform 0.1% (v/v) concentration to each batch lot. JP-8 is a kerosene-based fuel containing different compounds that vary in the content of every batch/lot of fuel; thus, MEAA has the potential to be a more specific and a consistent quantitative biomarker for JP-8 exposure. METHODS: MEAA was used to measure exposure of jet propulsion fuel 8 (JP-8) in United States Air Force (USAF) personnel working at six airbases within the United States. Post-shift urine specimens from various personnel including high (n = 98), moderate (n = 38), and low (n = 61) exposure workgroup categories were collected and analyzed by a gas chromatographic-mass spectrometric test method. The three exposure groups were evaluated for the number per group positive for MEAA, and a statistical analysis consisted of pair-wise t-tests for unequal variances was used to test for the differences in mean MEAA concentrations between the exposure groups. RESULTS: The number of samples detected as positive for MEAA exposure, that is, those above the test method's limit of detection (LOD = 0.1 µg/ml), were 92 (93.9%), 13 (34.2%), and 2 (3.3%) for the high, moderate, and low exposure workgroup categories, respectively. The mean urinary MEAA level was significantly greater in the high exposure category (6.8 µg/ml), compared to the moderate (0.42 µg/ml) and the low (0.07 µg/ml) exposure categories. The maximum concentration of urinary MEAA was 110 µg/ml for the high exposure category, while 4.8 µg/ml and 0.2 µg/ml maximum levels were found in the moderate and low exposure categories, respectively. CONCLUSION: This study demonstrated that urinary MEAA can be used as an accurate biomarker of exposure for JP-8 workers and clearly distinguished the differences in JP-8 exposure by workgroup category.


Asunto(s)
Acetatos/orina , Biomarcadores/orina , Creatinina/orina , Hidrocarburos/metabolismo , Exposición Profesional/análisis , Humanos , Personal Militar , Estados Unidos
14.
Artículo en Inglés | MEDLINE | ID: mdl-36011533

RESUMEN

This study aimed to assess temporary and permanent auditory effects associated with occupational coexposure to low levels of noise and solvents. Cross-sectional study with 25 printing industry workers simultaneously exposed to low noise (<80 dBA TWA) and low levels of solvents. The control group consisted of 29 industry workers without the selected exposures. Participants answered a questionnaire and underwent auditory tests. Auditory fatigue was measured by comparing the acoustic reflex threshold before and after the workday. Workers coexposed to solvents and noise showed significantly worse results in auditory tests in comparison with the participants in the control group. Auditory brainstem response results showed differences in III−V interpeak intervals (p = 0.046 in right ear; p = 0.039 in left ear). Mean dichotic digits scores (exposed = 89.5 ± 13.33; controls = 96.40 ± 4.46) were only different in the left ear (p = 0.054). The comparison of pre and postacoustic reflex testing indicated mean differences (p = 0.032) between the exposed (4.58 ± 6.8) and controls (0 ± 4.62) groups. This study provides evidence of a possible temporary effect (hearing fatigue) at the level of the acoustic reflex of the stapedius muscle. The permanent effects were identified mainly at the level of the high brainstem and in the auditory ability of binaural integration.


Asunto(s)
Pérdida Auditiva Provocada por Ruido , Ruido en el Ambiente de Trabajo , Exposición Profesional , Estudios Transversales , Trastornos de la Audición , Humanos , Industrias , Ruido en el Ambiente de Trabajo/efectos adversos , Exposición Profesional/efectos adversos , Solventes/toxicidad
15.
Environ Res ; 111(8): 1293-301, 2011 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-22000761

RESUMEN

Atrazine is the most commonly used herbicide in the U.S. and a wide-spread groundwater contaminant. Epidemiologic and laboratory evidence exists that atrazine disrupts reproductive health and hormone secretion. We examined the relationship between exposure to atrazine in drinking water and menstrual cycle function including reproductive hormone levels. Women 18-40 years old residing in agricultural communities where atrazine is used extensively (Illinois) and sparingly (Vermont) answered a questionnaire (n=102), maintained menstrual cycle diaries (n=67), and provided daily urine samples for analyses of luteinizing hormone (LH), and estradiol and progesterone metabolites (n=35). Markers of exposures included state of residence, atrazine and chlorotriazine concentrations in tap water, municipal water and urine, and estimated dose from water consumption. Women who lived in Illinois were more likely to report menstrual cycle length irregularity (odds ratio (OR)=4.69; 95% confidence interval (CI): 1.58-13.95) and more than 6 weeks between periods (OR=6.16; 95% CI: 1.29-29.38) than those who lived in Vermont. Consumption of >2 cups of unfiltered Illinois water daily was associated with increased risk of irregular periods (OR=5.73; 95% CI: 1.58-20.77). Estimated "dose" of atrazine and chlorotriazine from tap water was inversely related to mean mid-luteal estradiol metabolite. Atrazine "dose" from municipal concentrations was directly related to follicular phase length and inversely related to mean mid-luteal progesterone metabolite levels. We present preliminary evidence that atrazine exposure, at levels below the US EPA MCL, is associated with increased menstrual cycle irregularity, longer follicular phases, and decreased levels of menstrual cycle endocrine biomarkers of infertile ovulatory cycles.


Asunto(s)
Atrazina/toxicidad , Estradiol/orina , Hormona Luteinizante/orina , Ciclo Menstrual/efectos de los fármacos , Progesterona/orina , Contaminantes Químicos del Agua/toxicidad , Adolescente , Adulto , Exposición a Riesgos Ambientales , Femenino , Humanos , Illinois , Encuestas y Cuestionarios , Vermont , Abastecimiento de Agua
16.
Int J Audiol ; 50(10): 652-60, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21812635

RESUMEN

OBJECTIVE: The objective of this study was to evaluate hearing loss among workers exposed to styrene, alone or with noise. DESIGN: This cross-sectional study was conducted as part of NoiseChem, a European Commission 5th Framework Programme research project, by occupational health institutes in Finland, Sweden, and Poland. STUDY SAMPLE: Participants' ages ranged from 18-72 years (n = 1620 workers). Participants exposed to styrene, alone or with noise, were from reinforced fiberglass products manufacturing plants (n = 862). Comparison groups were comprised of workers noise-exposed (n = 400) or controls (n = 358). Current styrene exposures ranged from 0 to 309 mg/m(3), while mean current noise levels ranged from 70-84 dB(A). Hearing thresholds of styrene-exposed participants were compared with Annexes A and B from ANSI S3.44, 1996. RESULTS: The audiometric thresholds of styrene exposed workers were significantly poorer than those in published standards. Age, gender, and styrene exposure met the significance level criterion in the multiple logistic regression for the binary outcome 'hearing loss' (P = 0.0000). Exposure to noise (<85 dBA p = 0.0001; ≥85 dB(A) p = 0.0192) interacted significantly with styrene exposure. CONCLUSIONS: Occupational exposure to styrene is a risk factor for hearing loss, and styrene-exposed workers should be included in hearing loss prevention programs.


Asunto(s)
Audiometría de Tonos Puros , Pérdida Auditiva Provocada por Ruido/inducido químicamente , Pérdida Auditiva/inducido químicamente , Ruido/efectos adversos , Enfermedades Profesionales/inducido químicamente , Exposición Profesional , Solventes/efectos adversos , Estireno/efectos adversos , Estimulación Acústica , Adolescente , Adulto , Anciano , Umbral Auditivo , Estudios Transversales , Europa (Continente)/epidemiología , Femenino , Pérdida Auditiva/diagnóstico , Pérdida Auditiva/epidemiología , Pérdida Auditiva/prevención & control , Pérdida Auditiva Provocada por Ruido/diagnóstico , Pérdida Auditiva Provocada por Ruido/epidemiología , Pérdida Auditiva Provocada por Ruido/prevención & control , Humanos , Modelos Logísticos , Masculino , Persona de Mediana Edad , Enfermedades Profesionales/diagnóstico , Enfermedades Profesionales/epidemiología , Enfermedades Profesionales/prevención & control , Servicios de Salud del Trabajador , Valor Predictivo de las Pruebas , Servicios Preventivos de Salud , Medición de Riesgo , Factores de Riesgo , Adulto Joven
17.
Appl Ergon ; 91: 103300, 2021 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-33190057

RESUMEN

This study was conducted at 5 Veterans Administration Medical Centers (VAMCs). A cross sectional survey was administered to 134 workers who routinely lift and mobilize patients within their workplaces' safe patient handling and mobility (SPHM) programs, which are mandated in all VAMCs. The survey was used to examine a comprehensive list of SPHM and non-SPHM variables, and their associations with self-reported musculoskeletal injury and pain. Previously unstudied variables distinguished between "bariatric" (≥300 lb or 136 kg) and "non-bariatric" (<300 lb or 136 kg) patient handling. Significant findings from stepwise and logistic regression provide targets for workplace improvements, predicting: lower injury odds with more frequently having sufficient time to use equipment, higher back pain odds with more frequent bariatric handling, lower back pain odds with greater ease in following SPHM policies, and lower odds of upper extremity pain with more bariatric equipment, and with higher safety climate ratings.


Asunto(s)
Bariatria , Cuidadores , Movimiento y Levantamiento de Pacientes , Autoinforme , Estudios Transversales , Humanos , Dolor , Seguridad del Paciente , Administración de la Seguridad
18.
Bioelectromagnetics ; 31(5): 391-405, 2010 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-20213671

RESUMEN

To improve the assessment of magnetic field exposures for occupational health studies, the Multiwave System III (MW3) was developed to capture personal exposures to the three-dimensional magnetic field vector B(t) in the 0-3000 Hz band. To process hundreds of full-shift MW3 measurements from epidemiologic studies, new computer programs were developed to calculate the magnetic field's physical properties and its interaction with biological systems through various mechanisms (magnetic induction, radical pair interactions, ion resonance, etc.). For automated calculations in the frequency domain, the software uses new algorithms that remove artifacts in the magnetic field's Fourier transform due to electronic noise and the person's motion through perturbations in the geomagnetic field from steel objects. These algorithms correctly removed the Fourier transform artifacts in 92% of samples and have improved the accuracy of frequency-dependent metrics by as much as 3300%. The output of the MwBatch software is a matrix of 41 exposure metrics calculated for each 2/15 s sample combined with 8 summary metrics for the person's full-period exposure, giving 294 summary-exposure metrics for each person monitored. In addition, the MwVisualizer software graphically explores the magnetic field's vector trace, its component waveforms, and the metrics over time. The output was validated against spreadsheet calculations with pilot data. This software successfully analyzed full-shift MW3 monitoring with 507 electric utility workers, comprising over 1 million vector waveforms. The software's output can be used to test hypotheses about magnetic field biology and disease with biophysical models and also assess compliance with exposure limits.


Asunto(s)
Artefactos , Salud , Magnetismo , Exposición Profesional/efectos adversos , Humanos , Movimiento , Reproducibilidad de los Resultados , Programas Informáticos
19.
J Occup Environ Med ; 62(8): 595-610, 2020 08.
Artículo en Inglés | MEDLINE | ID: mdl-32404838

RESUMEN

OBJECTIVE: To update trends in prevalence of back and upper limb musculoskeletal symptoms and risk factors from the 2014 Quality of Work Life (QWL) Survey. METHODS: Quadrennial QWL Surveys, 2002 to 2014 (with N = 1455, 1537, 1019, and 1124 in 2002, 2006, 2010, and 2014 surveys respectively) were analyzed for reports of back pain and pain in arms. RESULTS: In the fourth analysis of this survey, 12-year trends continue to show a decline in back pain and pain in arms. Key physical (heavy lifting, hand movements, very hard physical effort) and psychosocial/work organizational factors (low supervisor support, work is always stressful, not enough time to get work done) remain associated with back and arm pain, with the physical risk factors showing the strongest associations. CONCLUSION: Physical exposure risk factors continue to be strongly associated with low back and arm pain and should be the focus of intervention strategies.


Asunto(s)
Enfermedades Musculoesqueléticas , Enfermedades Profesionales , Dolor de Espalda/epidemiología , Humanos , Enfermedades Musculoesqueléticas/epidemiología , Enfermedades Profesionales/epidemiología , Prevalencia , Calidad de Vida , Factores de Riesgo , Encuestas y Cuestionarios
20.
J Acoust Soc Am ; 125(5): 3262-77, 2009 May.
Artículo en Inglés | MEDLINE | ID: mdl-19425669

RESUMEN

The National Institute for Occupational Safety and Health and the Environmental Protection Agency sponsored the completion of an interlaboratory study to compare two fitting protocols specified by ANSI S12.6-1997 (R2002) [(2002). American National Standard Methods for the Measuring Real-Ear Attenuation of Hearing Protectors, American National Standards Institute, New York]. Six hearing protection devices (two earmuffs, foam, premolded, custom-molded earplugs, and canal-caps) were tested in six laboratories using the experimenter-supervised, Method A, and (naive) subject-fit, Method B, protocols with 24 subjects per laboratory. Within-subject, between-subject, and between-laboratory standard deviations were determined for individual frequencies and A-weighted attenuations. The differences for the within-subject standard deviations were not statistically significant between Methods A and B. Using between-subject standard deviations from Method A, 3-12 subjects would be required to identify 6-dB differences between attenuation distributions. Whereas using between-subject standard deviations from Method B, 5-19 subjects would be required to identify 6-dB differences in attenuation distributions of a product tested within the same laboratory. However, the between-laboratory standard deviations for Method B were -0.1 to 3.0 dB less than the Method A results. These differences resulted in considerably more subjects being required to identify statistically significant differences between laboratories for Method A (12-132 subjects) than for Method B (9-28 subjects).


Asunto(s)
Dispositivos de Protección de los Oídos , Guías como Asunto , National Institute for Occupational Safety and Health, U.S. , United States Environmental Protection Agency , Algoritmos , Análisis de Varianza , Antropometría , Umbral Auditivo , Conducto Auditivo Externo/anatomía & histología , Femenino , Cabeza/anatomía & histología , Audición , Humanos , Masculino , Ajuste de Prótesis/métodos , Reproducibilidad de los Resultados , Estados Unidos , United States Environmental Protection Agency/legislación & jurisprudencia
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