1.
Bioorg Med Chem Lett
; 22(15): 5098-103, 2012 Aug 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-22749419
RESUMEN
Lead optimization efforts that employed structure base drug design and physicochemical property based optimization leading to the discovery of a novel series of 4-methylpyrido pyrimidinone (MPP) are discussed. Synthesis and profile of 1, a PI3Kα/mTOR dual inhibitor, is highlighted.