1.
Org Lett
; 5(15): 2695-8, 2003 Jul 24.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12868892
RESUMEN
[structure: see text] A strategy to restrict the highly flexible backbone conformation of a peptide nucleic acid (PNA) by incorporation of a cyclopentane ring is proposed. An asymmetric synthesis of cyclopentane-modified PNA is reported, and its binding properties were determined. The cyclopentane ring leads to a significant improvement in the binding properties of the resulting PNA to DNA and RNA.