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1.
Sensors (Basel) ; 15(8): 18416-26, 2015 Jul 28.
Artículo en Inglés | MEDLINE | ID: mdl-26225981

RESUMEN

In this paper, we propose an AlGaN/GaN high electron mobility transistor (HEMT)-based biosensor for the detection of C-reactive protein (CRP) using a null-balancing circuit. A null-balancing circuit was used to measure the output voltage of the sensor directly. The output voltage of the proposed biosensor was varied by antigen-antibody interactions on the gate surface due to CRP charges. The AlGaN/GaN HFET-based biosensor with null-balancing circuit applied shows that CRP can be detected in a wide range of concentrations, varying from 10 ng/mL to 1000 ng/mL. X-ray photoelectron spectroscopy was carried out to verify the immobilization of self-assembled monolayer with Au on the gated region.


Asunto(s)
Compuestos de Aluminio/química , Técnicas Biosensibles/instrumentación , Proteína C-Reactiva/análisis , Electrones , Galio/química , Transistores Electrónicos , Electricidad , Humanos , Espectroscopía de Fotoelectrones
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