Detalles de la búsqueda
1.
Discovery and synthesis of cyclohexenyl derivatives as modulators of CC chemokine receptor 2 activity.
Bioorg Med Chem Lett
; 26(2): 662-666, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26631321
2.
N-Cyclo-hexyl-3-methyl-benzamidine.
Acta Crystallogr Sect E Struct Rep Online
; 69(Pt 4): o520, 2013 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23634064
3.
Cellular internalization of exosomes occurs through phagocytosis.
Traffic
; 11(5): 675-87, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20136776
4.
Membrane localization of beta-amyloid 1-42 in lysosomes: a possible mechanism for lysosome labilization.
J Biol Chem
; 285(26): 19986-96, 2010 Jun 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-20430896
5.
Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1' substituents.
Bioorg Med Chem Lett
; 18(6): 1958-62, 2008 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18282708
6.
Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents.
Bioorg Med Chem Lett
; 18(5): 1577-82, 2008 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18242982
7.
Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorg Med Chem Lett
; 18(4): 1288-92, 2008 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18234496
8.
Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE).
Bioorg Med Chem Lett
; 18(2): 694-9, 2008 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18061445
9.
Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors.
Bioorg Med Chem Lett
; 18(1): 241-6, 2008 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18032037
10.
Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR.
Invest Ophthalmol Vis Sci
; 48(2): 907-15, 2007 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-17251494
11.
Crystal structure of N'-(2,6-di-methyl-phen-yl)benzene-carboximidamide tetra-hydro-furan monosolvate.
Acta Crystallogr E Crystallogr Commun
; 71(Pt 1): o28-9, 2015 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25705489
12.
Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4).
Matrix Biol
; 21(6): 499-511, 2002 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-12392761
13.
Sultam hydroxamates as novel matrix metalloproteinase inhibitors.
J Med Chem
; 47(12): 2981-3, 2004 Jun 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-15163180
14.
Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.
J Med Chem
; 45(23): 4954-7, 2002 Nov 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-12408705
15.
Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors.
J Med Chem
; 46(10): 1811-23, 2003 May 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-12723945
16.
Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis.
J Med Chem
; 55(22): 9643-53, 2012 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-23075267
17.
Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorg Med Chem Lett
; 17(10): 2769-74, 2007 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17368021
18.
Synthesis and structure-activity relationship of a novel, non-hydroxamate series of TNF-alpha converting enzyme inhibitors.
Bioorg Med Chem Lett
; 17(16): 4678-82, 2007 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17576061
19.
Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorg Med Chem Lett
; 17(1): 266-71, 2007 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17027261
20.
Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorg Med Chem Lett
; 17(5): 1413-7, 2007 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17188863