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Cr3+ in the Ca3Sc2Si3O12 garnet (CSSG) has the ability to convert blue light to broadband near-infrared (NIR) emissions, which is a promising strategy for next-generation smart NIR light sources based on blue LEDs. The Cr3+ luminescence strongly depends on temperature due to electron-phonon coupling (EPC). We reveal the EPC mechanism of Cr3+ in CSSG for the first time by temperature-dependent photoluminescence measurement from 77 to 573 K and cathodoluminescence using a scanning electron microscope. Cr3+ occupies the Sc3+ site and experiences a weak crystal field in CSSG, manifesting a broad NIR emission in the 700-900 nm range that originates from the 4T2gâ4A2g transition. The zero phonon line (ZPL) of the 4T2 state is observed at â¼713 nm with a vibrational energy of â¼310 cm-1. A strong EPC leads to a large Stokes shift (â¼2900 cm-1). The Huang-Rhys parameter (S = 4), crystal field strength (Dq/B), and Racah parameters (B and C) are estimated.
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BACKGROUND The imbalance between bone resorption and formation is the basic mechanism underlying osteoporosis in the elderly. Osteogenesis is the differentiation of human mesenchymal stem cells (hMSCs) into osteoblasts. Sirtuin6 (SIRT6) regulates various biological functions, including differentiation. Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a non-selective cation channel that can be activated by physical and chemical stimulation. However, experimental data supporting the role of SIRT6 in osteogenic differentiation (OD) of hMSCs are lacking. MATERIAL AND METHODS Differentiation of hMSCs was induced. The expressions of SIRT6, TRPV1, and CGRP were detected by Q-PCR, Western blot, and ELISA, respectively. SIRT6 was overexpressed in hMSCs by transfection. ALP activity and Alizarin Red staining were utilized to detect the effect of SIRT6 on hMSC OD. Then, capsaicin and capsazepine, the TRPV1 agonist and antagonist, respectively, were administrated to assess the role of TRPV1. RESULTS SIRT6 expression was downregulated during hMSC differentiation. SIRT6 overexpression was accompanied by reduced expression of specific genes and alkaline phosphatase (ALP) activity in osteoblasts. Furthermore, TRPV1 channel was also reduced by SIRT6 overexpression via ubiquitinating TRPV1. Capsaicin was utilized in SIRT6-overexpressed cells. Capsaicin therapy counteracted the effect of SIRT6 overexpression on OD, and markedly decreased OD. CONCLUSIONS The SIRT6-TRPV1-CGRP signal axis is the key to regulating OD in hMSCs, which could be a potential therapeutic target for osteoporosis and bone loss-related diseases.
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Células Madre Mesenquimatosas/efectos de los fármacos , Osteogénesis/efectos de los fármacos , Sirtuinas/farmacología , Fosfatasa Alcalina/metabolismo , Células de la Médula Ósea/citología , Resorción Ósea/metabolismo , Péptido Relacionado con Gen de Calcitonina/genética , Péptido Relacionado con Gen de Calcitonina/metabolismo , Diferenciación Celular/efectos de los fármacos , Línea Celular Tumoral , China , Subunidad alfa 1 del Factor de Unión al Sitio Principal/metabolismo , Humanos , Células Madre Mesenquimatosas/citología , Células Madre Mesenquimatosas/metabolismo , Osteoblastos/metabolismo , Osteoporosis/metabolismo , Osteosarcoma/genética , Osteosarcoma/metabolismo , Sirtuinas/metabolismo , Canales Catiónicos TRPV/genética , Canales Catiónicos TRPV/metabolismoRESUMEN
BACKGROUND: Given that the CCDC92 (coiled-coil domain containing 92) was important in insulin resistance, we sought to investigate whether the CCDC92 rs825476 SNP is associated with the risk of CHD in Chinese Han population. METHODS: Rs11057401 was genotyped for 817 patients with CHD and 724 age- and sex-matched controls using PCR-based Invader assay with the probe sets designed and synthesized by third wave. RESULTS: Patients were found to have a significantly higher frequency of AA than the controls (23.5% vs. 14.7%, OR = 1.60, p = 0.000), and the frequency of allele A was found to be remarkably higher in the patients than the controls (48.1% vs. 40.3%, OR = 1.19, p = 0.000). Multivariate logistic analysis showed that the incidence of CHD was positively correlated with hyperlipidemia, T2D and rs11057401 AA/AT genotypes. The FPG, TC, and ApoA1 levels in the CHD patients were different among the AA, AT and TT genotypes (P < 0.05), the A allele carriers had higher FPG, TC and lower ApoA1 levels than the A allele non-carriers (P < 0.05). CONCLUSION: The genotypic and allelic frequencies of the rs11057401 SNP were significantly different between the patients with CHD and controls. Subjects with AA genotype or A allele were associated with an increased risk of CHD. The AA/AT genotypes were also associated with increased serum FPG, TC and decreased ApoA1 in CHD.
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Proteínas Portadoras/genética , Enfermedad Coronaria/genética , Diabetes Mellitus Tipo 2/genética , Hiperlipidemias/genética , Anciano , Alelos , Pueblo Asiatico , Enfermedad Coronaria/sangre , Enfermedad Coronaria/patología , Proteínas del Citoesqueleto , Diabetes Mellitus Tipo 2/sangre , Diabetes Mellitus Tipo 2/patología , Femenino , Estudios de Asociación Genética , Predisposición Genética a la Enfermedad , Genotipo , Humanos , Hiperlipidemias/sangre , Hiperlipidemias/patología , Lípidos/sangre , Masculino , Persona de Mediana Edad , Polimorfismo de Nucleótido Simple/genética , Factores de RiesgoRESUMEN
Samples of the Ba9 (Lu2-x Yx )Si6 O24 :Ce3+ (x = 0-2) blue-green phosphors were synthesized by solid-state reactions. All the samples exhibited a rhombohedral crystal structure. As the Y3+ concentration increased, the diffraction peaks shifted to the small angle region and the lattice parameters increased due to the larger ionic radius of Y3+ (r = 0.900 Å) compared with that of Lu3+ (r = 0.861 Å). Under 400 nm excitation, samples exhibited strong blue-green emissions around 490 nm. The emission bands had a slight blue shift that resulted from weak crystal-field splitting with increasing Y3+ concentration. Luminescence intensity and quantum efficiency (QE) decreased with increasing Y3+ concentration. The internal QE decreased from 74 to 50% and the external QE decreased from 50 to 34% as x increased from 0 to 2. The thermal stability of the Lu series was better than that of the Y-series. The excitation band peak around 400 nm matched well with the emission light from the efficient near-ultraviolet (NUV) chip. These results indicate promising applications for these NUV-based white light-emitting diodes.
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Sustancias Luminiscentes/química , Cerio/química , Color , Cristalización , Mediciones Luminiscentes , Lutecio/química , Polvos , Difracción de Rayos XRESUMEN
We obtain a blue phosphor, Ba9Lu2Si6O24:Eu(2+) (BLS:Eu(2+)), which shows a strong emission peak at 460 nm and a weak tail from 460 to 750 nm. A 610 nm red emission is observed for the first time in this kind of rhombohedral structure material, which is much different from the same crystal structure of Ba9Sc2Si6O24:Eu(2+) and Ba9Y2Si6O24:Eu(2+). The luminescence properties and decays from 10 to 550 K are discussed. The new red emission arises from a trapped exciton state of Eu(2+) at the Ba site with a larger coordination number (12-fold). It exhibits abnormal luminescence properties with a broad bandwidth and a large Stokes shift. Under the 400 nm excitation, the external quantum efficiency of BLS:Eu(2+) is 45.4%, which is higher than the 35.7% for the commercial blue phosphor BAM:Eu(2+). If the thermal stability of BLS:Eu(2+) can be improved, it will show promising applications in efficient near-UV-based white LEDs.
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Eu3+-doped MWO4 (M = Zn, Cd, Ca, Sr, or Ba) nanorods and rodlike, spherical, dumbbell-like, and double-tapter-like grains have been obtained via a hydrothermal method. The distinct differences in cationic radius lead to a special morphology, which is attributed to the symmetry of the crystal structure and the differences in the growth rates of various crystals, and it further leads to the variation of luminescence. It was found that the charge transfer band of MWO4:0.04Eu3+ exhibits a blue shift with an increasing cationic radius, and the shift is ascribed to less covalency being caused by an increase in the cationic radius. The emission intensity obviously increases with cationic radius, increasing for the samples with a monoclinic phase; however, it is the opposite for the samples with a tetragonal phase, and CaWO4:0.04Eu3+ exhibits an optimal emission intensity. In addition, the possible reasons for the decay lifetime are also discussed in detail. Our results indicate that cations can effectively control the crystal structure, micromorphology, and luminescence in tungstate phosphors, and thus, our approach is effective for obtaining materials with the desired morphology and crystal structure.
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Gadolinium gallium aluminum garnet (GGAG) is a very promising host for the highly efficient luminescence of Ce(3+) and shows potential in radiation detection applications. However, the thermodynamically metastable structure would be slanted against it from getting high transparency. To stabilize the crystal structure of GGAG, Yb(3+) ions were codoped at the Gd(3+) site. It is found that the decomposition of garnet was suppressed and the transparency of GGAG ceramic was evidently improved. Moreover, the photoluminescence of GGAG:Ce(3+),xYb(3+) with different Yb(3+) contents has been investigated. When the Ce(3+) ions were excited under 475 nm, a typical near-infrared region emission of Yb(3+) ions can be observed, where silicon solar cells have the strongest absorption. Basing on the lifetimes of Ce(3+) ions in the GGAG:Ce(3+),xYb(3+) sample, the transfer efficiency from Ce(3+) to Yb(3+) and the theoretical internal quantum efficiency can be calculated and reach up to 86% and 186%, respectively. This would make GGAG:Ce(3+),Yb(3+) a potential attractive downconversion candidate for improving the energy conversion efficiency of crystalline silicon (c-Si) solar cells.
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In this Letter, we report the addition of Pr3+ and Mg2+ in CSS:Ce3+, Mn2+ phosphor for improving the performances of white light-emitting diodes (LEDs). The additional trivalent Pr3+ will occupy the Ca2+ site in this host like the situation of Ce3+, its concentration can be enhanced by the addition of Mg2+ in Sc3+ site due to the substitution of Mg2+ for Sc3+ can compensate the charge mismatch between Pr3+ and Ca2+. Based on the efficient Ce3+âPr3+ and Mn2+âPr3+ energy transfers (ETs) and the compensation effect of Mg2+, the additional Pr3+ in our present phosphors exhibits an intense red-emission around 610 nm, which is significant for enhancing the color rendering property. In addition, we also find that the additional Mg2+ in Sc3+ site can markedly adjust the photoluminescence (PL) spectrum shape of our phosphor by controlling the distribution of Mn2+ at Ca2+ and Sc3+ sites. A new tunable full-color emission is obtained via the ETs (Ce3+âMn2+, Ce3+âPr3+ and Mn2+âPr3+) and the adjusting effect of Mg2+ in our present phosphors. Finally, a white LED with higher color rendering index of 90, lower correlated color temperature of 4980 K, and chromaticity coordinates of (0.34, 0.31) was obtained by combining the single CSS:0.08Ce3+, 0.01Pr3+, 0.3Mn2+, 0.2Mg2+ phosphor with a blue-emitting InGaN LED chip.
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OBJECTIVE: To identify non-invasive biomarkers for diagnosis and/or prognosis of liver fibrosis in chronic hepatitis B (CHB). METHODS: Peripheral blood samples were obtained from 48 patients with CHB, including 24 with mild fibrosis (stage 1, S1) and 24 with severe fibrosis (stage 4, S4), and subjected to Ficoll density gradient centrifugation in order to obtain enriched samples of peripheral blood mononuclear cells (PBMCs).The PBMC proteomes of the two groups were assessed by first separating the total proteins by two-dimensional gel electrophoresis (2DE) and then identifying the differentially expressed proteins by liquid chromatography combined with tandem mass spectrometry (LCMS/MS). RESULTS: The enriched PBMC samples from the S1 group and the S4 group had similar amounts of platelets [(19.268+/- 6.413) * 109/L and(19.480+/- 6.538) * 109/L, respectively); however, for both, the platelet amounts were 5 to 15-fold lower than that of the normal reference (100-300 *109/L). There was no significant difference found between the platelet amounts in the S1 patients and healthy controls (P=0.930). Twelve differentially expressed proteins were identified through 2DE-LC-MS/MS, including proteins such as moesin and NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 that are involved in various biological processes like cell movement, cell adhesion, kinase signaling and transcription. CONCLUSION: s The 12 proteins with differential expression in S1 and S4 patients with CHB and liver fibrosis may represent markers related to development and/or progression of liver fibrosis.
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Hepatitis B Crónica/complicaciones , Leucocitos Mononucleares/metabolismo , Cirrosis Hepática/metabolismo , Cirrosis Hepática/patología , Biomarcadores , Progresión de la Enfermedad , Electroforesis en Gel Bidimensional , Humanos , Leucocitos Mononucleares/química , Cirrosis Hepática/etiología , Espectrometría de Masas , Pronóstico , Proteoma , Proteómica , Espectrometría de Masas en TándemRESUMEN
Objectives: This study aimed to quantitatively analyze the effects of neuromuscular training (NMT) on dynamic balance in healthy athletes through a systematic review and meta-analysis of randomized controlled trials. Methods: Searches on six databases for randomized controlled trials examining the impact of NMT on athletes' balance ability. The search period extended from the inception of the database to March 16, 2024, languages are limited to Chinese and English. Review Manager 5.1 was used for literature quality assessment and data analysis. Stata 15.0 software was used for assessing publication bias, employing the clipping method, and conducting sensitivity analysis. The Grading of recommendations assessment development and evaluation (GRADE) was used to assess the certainty of evidence. Effect size (ES) was used to evaluate the impact effect of the results. Results: (1) Meta-analysis: A total of 7 papers met the inclusion criteria, and the meta-analysis indicated that NMT had a positive impact on the dynamic balance ability of the right (SMD = 0.74) and left (SMD = 0.70) lower limb of athletes, and a statistically significant difference was observed (p < 0.01). Subgroup analysis revealed that NMT did not have a positive effect (p > 0.05) on the right anterior (SMD = 0.35); However, it had a positive effect (p < 0.05) on the right posteromedial (SMD = 1.22), right posterolateral (SMD = 0.82), right composite score (SMD = 0.79), left anterior (SMD = 0.38), left posteromedial (SMD = 1.19), left posterolateral (SMD = 0.57) and left composite score (SMD = 0.86). (2) Reporting bias: Funnel plot indicated evidence of publication bias, but there was no significant asymmetry in the funnel plot after trimming and filling. The results were not reversed, indicating the robustness of the combined results. (3) Sensitivity analysis: The results of the sensitivity analysis suggest that the data in this meta-analysis are relatively stable and credible. (4) Grading the evidence: Based on GRADE scale the certainty of evidence from the included studies was determined to be moderate. Conclusion: Neuromuscular training can enhance the dynamic balance ability of athletes on both the left and right sides. Therefore, neuromuscular training is an effective method for enhancing the unilateral dynamic balance ability of athletes.
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In this Letter, we study diffuse reflectance and photoluminescence spectra for O(2-) fully coordinated green-emitting Ce(3+) and N(3-) partially coordinated red Ce(3+) in Ca(3)Sc(2)Si(3)O(12)(CSS):Ce(3+), N(3-) as a function of CeO(2) and Si(3)N(4) contents in the raw material. Our results indicate that the presence of N(3-) can enhance Ce(3+) solubility in the form of red centers in CSS. At low Ce(3+) concentration, green Ce(3+) forms preferentially while red Ce(3+) hardly forms even if N(3-) content in the raw material is sufficient. There exists a threshold concentration of green Ce(3+); only beyond that can color tunable luminescence with enriched red emission be achieved. Energy transfer from green Ce(3+) to red Ce(3+) is also studied, as only the green Ce(3+) is excited by blue light.
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With the aging of China's population and the expansion of household debt, the health of the elderly has become an important social issue. Based on the 2018 China Family Panel Studies (CFPS) database, we explored the impact of household debt on the health of older adults and the mechanism of transmission. The Oprobit and IV-Oprobit models were employed for our analysis. Results: (1) Household debt had a significant negative impact on both the physical and mental health of older adults. (2) Female older adults were more sensitive to the impact of household debt. Additionally, a higher education level led to an increasing impact of debt on mental health, but physical health was only affected in the low-education group. (3) The impact of household debt had an inverted U-shape relationship with household income, indicating that, as household income increases, the impact on health level first rises and then reduces after peaking at a middling level of income. (4) According to the mechanism analysis, household debt affects the health of the elderly by causing them to return to work and reducing their medical expenditures. Considering the above conclusions, we put forward some policy implications to alleviate the health problems of the elderly.
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Estado de Salud , Renta , Humanos , Femenino , Anciano , China/epidemiología , Gastos en Salud , PolíticasRESUMEN
In this study, we aimed to develop an invasion-related risk signature and prognostic model for personalized treatment and prognosis prediction in skin cutaneous melanoma (SKCM), as invasion plays a crucial role in this disease. We identified 124 differentially expressed invasion-associated genes (DE-IAGs) and selected 20 prognostic genes (TTYH3, NME1, ORC1, PLK1, MYO10, SPINT1, NUPR1, SERPINE2, HLA-DQB2, METTL7B, TIMP1, NOX4, DBI, ARL15, APOBEC3G, ARRB2, DRAM1, RNF213, C14orf28, and CPEB3) using Cox and LASSO regression to establish a risk score. Gene expression was validated through single-cell sequencing, protein expression, and transcriptome analysis. Negative correlations were discovered between risk score, immune score, and stromal score using ESTIMATE and CIBERSORT algorithms. High- and low-risk groups exhibited significant differences in immune cell infiltration and checkpoint molecule expression. The 20 prognostic genes effectively differentiated between SKCM and normal samples (AUCs >0.7). We identified 234 drugs targeting 6 genes from the DGIdb database. Our study provides potential biomarkers and a risk signature for personalized treatment and prognosis prediction in SKCM patients. We developed a nomogram and machine-learning prognostic model to predict 1-, 3-, and 5-year overall survival (OS) using risk signature and clinical factors. The best model, Extra Trees Classifier (AUC = 0.88), was derived from pycaret's comparison of 15 classifiers. The pipeline and app are accessible at https://github.com/EnyuY/IAGs-in-SKCM.
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Melanoma , Neoplasias Cutáneas , Humanos , Melanoma/genética , Neoplasias Cutáneas/genética , Pronóstico , Serpina E2 , Proteínas de Unión al ARN , Adenosina Trifosfatasas , Ubiquitina-Proteína Ligasas , Melanoma Cutáneo MalignoRESUMEN
A phosphor-converted light-emitting diode (pc-LED) is a prime light source in smart broadband near-infrared (NIR) spectroscopy. The performance of NIR pc-LEDs crucially depends on the employed NIR luminescent materials. In this study, we synthesized a novel high-efficiency broadband NIR phosphor, CaY2Mg2Ge3O12:Cr3+ (CYMG:Cr3+). Under 450 nm excitation, CYMG:Cr3+ exhibited remarkable broadband NIR emission from 650 to 900 nm with a full width at half maximum (FWHM) of 115 nm. Within the CYMG lattice, the Cr3+ ion occupies Ca/Y sites in the dodecahedron Ca/YO8 and Mg sites in the octahedron MgO6, giving rise to two distinct Cr3+ luminescence centers. Remarkably, the emission at 100 °C remained at 92% of its room temperature intensity and 81% at 150 °C, showcasing its exceptional thermal stability. The internal quantum efficiency (IQE) reached an impressive 81.1%, with an activation energy ΔE of 0.324 eV. Furthermore, we integrated the CYMG:Cr3+ phosphor with a commercial 450 nm blue chip to fabricate a micro NIR pc-LED, which exhibited stable NIR emission across different driving currents, with a NIR output power of 49.65 mW@400 mA and a photoelectric conversion efficiency of 10.52% at 20 mA. All findings highlight CYMG:Cr3+ as a stable and efficient broadband luminescent material for high-performance NIR LEDs.
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BACKGROUND: CD4 count or CD4/CD8 ratio has been found to be a valuable marker of disease progression in HIV and AIDS. Our objective was to evaluate preoperative CD4 count or CD4/CD8 ratio as a useful indicator for postoperative sepsis in HIV-infected patients undergoing abdominal operations. METHODS: Retrospective analysis of 35 HIV-infected patients (four females, 31 males) undergoing abdominal operations. All patients were divided into postoperative sepsis group (A) and non-sepsis group (B). Demographic and clinical information were entered into a database and included: type of surgical procedure, age, peripheral blood cells, plasma albumin, CD4 counts, and CD4/CD8 ratios. Furthermore, we stratified and compared the incidence of postoperative sepsis according to the preoperative CD4 counts with breakpoint value of 200 cells/µL and preoperative CD4/CD8 ratios with breakpoint value of 0.15. RESULTS: Overall postoperative sepsis morbidity in our study was 51.43% (18/35). In sepsis group, the mean preoperative and postoperative CD4 counts, CD4/CD8 ratios, and postoperative platelet count were found significantly lower, respectively, than those in non-sepsis group (P < 0.05). The incidence of postoperative sepsis in the patients with preoperative CD4 counts ≤ 200 cells/µL was markedly higher than those with CD4 counts > 200 cells/µL (83.3% versus 17.65%; P = 0.000). Likewise, the incidence of postoperative sepsis in the patients with preoperative CD4/CD8 ratios ≤ 0.15 was dramatically higher than those with CD4/CD8 ratios > 0.15 (90% versus 36%; P = 0.007). CONCLUSIONS: Our preliminary study showed that HIV-infected patients with preoperative CD4 count ≤ 200 cells/µL or CD4/CD8 ratio ≤ 0.15 had overall higher postoperative sepsis morbidity. Preoperative CD4 count or CD4/CD8 ratio may be used as a useful indicator for postoperative sepsis in HIV-infected patients undergoing abdominal operations.
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Abdomen/cirugía , Recuento de Linfocito CD4 , Relación CD4-CD8 , Infecciones por VIH/inmunología , Complicaciones Posoperatorias/inmunología , Sepsis/inmunología , Adulto , Anciano , Femenino , Infecciones por VIH/complicaciones , Humanos , Masculino , Persona de Mediana Edad , Periodo Preoperatorio , Estudios Retrospectivos , Sepsis/complicacionesRESUMEN
This paper measures the transformation and upgrading of industrial structure from two aspects of rationalization and upgrading of industrial structure, and empirically analyzes the impact of environmental regulation on industrial structure transformation and upgrading by using data of 29 provinces in China from 2004 to 2015. It was found that there is a significant nonlinear effect between environmental regulation and the transformation and upgrading of industrial structure. Specifically, environmental regulation is not conducive to the rational development of industrial structure, but with the continuous improvement of economic development level and human capital level, the inhibitory effect of environmental regulation on the rationalization of industrial structure is gradually weakened. The influence coefficient of environmental regulation on the rationalization of industrial structure is 0.0619~0.2648. Moreover, environmental regulation effectively drives the upgrading of industrial structure, and when the level of economic development and human capital are higher than the threshold, the role of environmental regulation in promoting the high development of industrial structure is gradually enhanced. The influence coefficient of environmental regulation on the upgrading of industrial structure is 0.0540~0.5626. Therefore, it is of great significance to formulate appropriate environmental regulation policies according to local conditions in the transformation and upgrading of industrial structure.
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Desarrollo Económico , Industrias , China , Política Ambiental , HumanosRESUMEN
The amount of concrete needed in the construction of projects is enormous. The concrete dispatching in construction is, however, chaotic and causes grievous waste due to the tight construction schedule, heavy tasks, and improper transport vehicle dispatching by the constructor. This paper proposes a more realistic objective function in the vehicle dispatching algorithm and offers a solution to the rational dispatching of concrete transport vehicles. The analysis of the calculation example validates the feasibility of the built model, which provides more appropriate dispatching and more balanced distribution, meets the needs of the worksite and mixing station to the greatest extent and improves the level of project refinement and process management. Therefore, the model is worth promoting in future practice.
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LEDs for plant lighting have attracted wide attention and phosphors with good stability and deep-red emission are urgently needed. Novel Cr3+ and Dy3+ co-doped Gd3Al4GaO12 garnet (GAGG) phosphors were successfully prepared through a conventional solid-state reaction. Using blue LEDs, a broadband deep-red emission at 650−850 nm was obtained due to the Cr3+ 4T2 â 4A2 transition. When the Cr3+ concentration was fixed to 0.1 mol, the crystal structure did not change with an increase in the Dy3+ doping concentration. The luminous intensity of the optimized GAGG:0.1Cr3+, 0.01Dy3+ was 1.4 times that of the single-doped GAGG:0.1Cr3+. Due to the energy transfer from Dy3+ to Cr3+, the internal quantum efficiency reached 86.7%. The energy transfer from Dy3+ to Cr3+ can be demonstrated through luminescence spectra and fluorescence decay. The excellent properties of the synthesized phosphor indicate promising applications in the agricultural industry.
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Chronic hepatitis B virus (HBV) infection is a worldwide disease that causes thousands of deaths per year. Currently, there is no therapeutic that can completely cure already infected HBV patients due to the inability of humans to eliminate covalently closed circular DNA (cccDNA), which serves as the template to (re)initiate an infection even after prolonged viral suppression. Through phenotypic screening, we discovered xanthone series hits as novel HBV cccDNA reducers, and subsequent structure optimization led to the identification of a lead compound with improved antiviral activity and pharmacokinetic profiles. A representative compound 59 demonstrated good potency and oral bioavailability with no cellular toxicity. In an HBVcircle mouse model, compound 59 showed excellent efficacy in significantly reducing HBV antigens, DNA, and intrahepatic cccDNA levels.
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Hepatitis B Crónica , Hepatitis B , Animales , Antivirales/farmacología , Antivirales/uso terapéutico , ADN Circular , ADN Viral/genética , Hepatitis B/tratamiento farmacológico , Virus de la Hepatitis B/genética , Hepatitis B Crónica/tratamiento farmacológico , Humanos , Ratones , Replicación ViralRESUMEN
Y3 Al5 O12 :Ce3+ (YAG:Ce3+ ) transparent ceramic phosphors (TCPs) are regarded as the most promising luminescent converter for laser-driven (LD) lighting. High-quality YAG:Ce3+ TCPs are still urgent for high efficiency LD lighting devices. YAG:Ce3+ TCPs in a vacuum ambience by using nano-sized raw materials are prepared. Controlling defects by adding nano-sized MgO and SiO2 simultaneously enables a high transmittance nearly 80%. After annealing in air furthermore, the luminous efficiency is enhanced greatly from 106 to 223 lm W-1 , which is the best result reported now for LD lighting. These results demonstrate that the optimizing YAG:Ce3+ TCPs in a fitting strategy will brighten once again in the next-generation LD lighting. Based on scanning electron microscopy (SEM) coupled with a cathodoluminescence system, defects and Ce3+ distributions in grains are identified directly for the first time.