Cumulative Effective Dose and Cancer Risk of Pediatric Population in Repetitive Whole-Body Scan Using Dual-Energy X-Ray Absorptiometry.

This study aims to quantitatively evaluate the cumulative effective dose and associated cancer risk of pediatric patients of US and Hong Kong population undergoing repetitive whole-body scans with dual-energy X-ray absorptiometry (DXA) during their diagnosis and follow-up periods. Organ-absorbed doses of pediatric patients undergoing DXA whole-body scan have been computer simulated using patient imaging parameters input to the Monte Carlo software PCXMC. Gender- and age-specific effective doses have been calculated with the simulated organ-absorbed doses using the ICRP-103 approach. The associated radiation-induced cancer risk, expressed as lifetime attributable cancer risk (LAR), has been estimated according to the method introduced in the Biological Effects of Ionizing Radiation VII report. Mathematical fitting for effective dose and for LAR, as a function of age at exposure, has been analytically obtained to quantitatively estimate the cumulated effective dose and LAR for pediatric patients of US and Hong Kong population with repetitive DXA whole-body scan during their follow-up period. The effective dose of a single DXA whole-body scan for patients exposed at the age between 5 and 18 years was calculated as 8.47-17.68 µSv. The corresponding LAR for US and Hong Kong population was between the range of 4.57 × 10-7 and 7.14 × 10-7. The cumulative effective dose of DXA whole-body scan for patients exposed annually at age between 5 and 18 years was calculated as 180 µSv for girls and 168 µSv for boys. The corresponding cumulative LAR for US and Hong Kong population was calculated as 3.77 × 10-6 to 5.48 × 10-6. Girls would be at a statistically significant higher cumulated cancer risk than boys under the same whole-body DXA protocol (p = 0.03). The probability of cumulative LAR for pediatric populations undergoing annual DXA whole-body scan is regarded as minimal. We demonstrate the use of computer simulation and analytic formulation to quantitatively obtain the cumulated effective dose and cancer risk at any age of exposure, which are useful information for medical personnel to track patient radiation dose and to alleviate patients' parents concern about radiation safety in repetitive whole-body scan using DXA.

Cumulative effective dose and cancer risk for pediatric population in repetitive full spine follow-up imaging: How micro dose is the EOS microdose protocol?

OBJECTIVE: To evaluate and to obtain analytic formulation for the calculation of the effective dose and associated cancer risk using the EOS microdose protocol for scoliotic pediatric patients undergoing full spine imaging at different age of exposure; to demonstrate the microdose protocol capable of delivering lesser radiation dose and hence of further reducing cancer risk induction when compared with the EOS low dose protocol; to obtain cumulative effective dose and cancer risk for both genders scoliotic pediatrics of US and Hong Kong population using the microdose protocol. METHODS: Organ absorbed doses of full spine exposed scoliotic pediatric patients have been simulated with the use of EOS microdose protocol imaging parameters input to the Monte Carlo software PCXMC. Gender and age specific effective dose has been calculated with the simulated organ absorbed dose using the ICRP-103 approach. The associated radiation induced cancer risk, expressed as lifetime attributable risk (LAR), has been estimated according to the method introduced in the Biological Effects of Ionizing Radiation VII report. Values of LAR have been estimated for scoliotic patients exposed repetitively during their follow up period at different age for US and Hong Kong population. RESULTS: The effective doses of full spine imaging with simultaneous posteroanterior and lateral projection for patients exposed at the age between 5 and 18 years using the EOS microdose protocol have been calculated within the range of 2.54-14.75 µSv. The corresponding LAR for US and Hong Kong population was ranged between 0.04 × 10-6 and 0.84 × 10-6. Cumulative effective dose and cancer risk during follow-up period can be estimated using the results and are of information to patients and their parents. CONCLUSION: With the use of computer simulation and analytic formulation, we obtained the cumulative effective dose and cancer risk at any age of exposure for pediatric patients of US and Hong Kong population undergoing repetitive microdose protocol full spine imaging. Girls would be at a statistically significant higher cumulative cancer risk than boys undergoing the same microdose full spine imaging protocol and the same follow-up schedule.

Closed-loop control of compression paddle motion to reduce blurring in mammograms.

BACKGROUND: Since the introduction of full field digital mammography (FFDM) a large number of UK breast cancer screening centers have reported blurred images, which can be caused by movement at the compression paddle during image acquisition. PURPOSE: To propose and investigate the use of position feedback from the breast side of the compression paddle to reduce the settling time of breast side motion. METHOD: Movement at the breast side of the paddle was measured using two calibrated linear potentiometers. A mathematical model for the compression paddle, machine drive, and breast was developed using the paddle movement data. Simulation software was used to optimize the position feedback controller parameters for different machine drive time constants and simulate the potential performance of the proposed system. RESULTS: The results obtained are based on simulation alone and indicate that closed-loop control of breast side paddle position dramatically reduced the settling time from over 90 s to less than 4 s. The effect of different machine drive time constants on the open-loop response is insignificant. With closed-loop control, the larger the time constant the longer the time required for the breast side motion to settle. CONCLUSIONS: Paddle motion induced blur could be significantly reduced by implementing the proposed closed-loop control.

Blurred digital mammography images: an analysis of technical recall and observer detection performance.

OBJECTIVE: Blurred images in full-field digital mammography are a problem in the UK Breast Screening Programme. Technical recalls may be due to blurring not being seen on lower resolution monitors used for review. This study assesses the visual detection of blurring on a 2.3-MP monitor and a 5-MP report grade monitor and proposes an observer standard for the visual detection of blurring on a 5-MP reporting grade monitor. METHODS: 28 observers assessed 120 images for blurring; 20 images had no blurring present, whereas 100 images had blurring imposed through mathematical simulation at 0.2, 0.4, 0.6, 0.8 and 1.0 mm levels of motion. Technical recall rate for both monitors and angular size at each level of motion were calculated. χ2 tests were used to test whether significant differences in blurring detection existed between 2.3- and 5-MP monitors. RESULTS: The technical recall rate for 2.3- and 5-MP monitors are 20.3% and 9.1%, respectively. The angular size for 0.2- to 1-mm motion varied from 55 to 275 arc s. The minimum amount of motion for visual detection of blurring in this study is 0.4 mm. For 0.2-mm simulated motion, there was no significant difference [χ2 (1, N = 1095) = 1.61, p = 0.20] in blurring detection between the 2.3- and 5-MP monitors. CONCLUSION: According to this study, monitors ≤2.3 MP are not suitable for technical review of full-field digital mammography images for the detection of blur. Advances in knowledge: This research proposes the first observer standard for the visual detection of blurring.

Evaluation of cumulative effective dose and cancer risk from repetitive full spine imaging using EOS system: Impact to adolescent patients of different populations.

OBJECTIVE: To evaluate the effective dose and associated cancer risk using EOS system for scoliotic adolescent patients undergoing full spine imaging at different age of exposure; to demonstrate EOS system capable of delivering less radiation dose and hence of reducing cancer risk induction when compared with conventional digital X-ray systems; to obtain cumulative effective dose and cancer risk for both genders scoliotic adolescence of US and Hong Kong population. METHODS: Organ absorbed doses of full spine exposed scoliotic adolescent patients using EOS system have been simulated with the use of patient imaging parameters input to the Monte Carlo software PCXMC. Gender specific effective dose has been calculated with the simulated organ absorbed dose using the ICRP-103 approach. The associated radiation induced cancer risk, expressed as lifetime attributable risk (LAR), has been estimated according to the method introduced in the Biological Effects of Ionizing Radiation VII report. Values of LAR were estimated for scoliotic patients exposed repetitively during their follow up period at different adolescent age for US and Hong Kong population. RESULTS: The effective dose of full spine imaging with posteroanterior and lateral projection for patients exposed at the age between 10-18 years using the EOS system low dose protocol was calculated between 86 and 140µSv. The corresponding LAR for US and Hong Kong population was ranged between 0.81×10-6 and 6.00×10-6. Cumulative effective dose and cancer risk during follow-up period can be estimated using the results and are of information to patients and their parents. CONCLUSION: With the use of computer simulation and analytic formulation, we obtained the cumulative effective dose and cancer risk at any age of exposure for adolescent patients of US and Hong Kong population undergoing repetitive full spine imaging using the EOS system. Female scoliotic patients would be at a statistically significant higher effective dose and cumulative cancer risk than the male patients undergoing the same EOS full spine imaging protocol.

Analysis of motion during the breast clamping phase of mammography.

OBJECTIVE: To measure paddle motion during the clamping phase of a breast phantom for a range of machine/paddle combinations. METHODS: A deformable breast phantom was used to simulate a female breast. 12 mammography machines from three manufacturers with 22 flexible and 20 fixed paddles were evaluated. Vertical motion at the paddle was measured using two calibrated linear potentiometers. For each paddle, the motion in millimetres was recorded every 0.5 s for 40 s, while the phantom was compressed with 80 N. Independent t-tests were used to determine differences in paddle motion between flexible and fixed, small and large, GE Senographe Essential (General Electric Medical Systems, Milwaukee, WI) and Hologic Selenia Dimensions paddles (Hologic, Bedford, MA). Paddle tilt in the medial-lateral plane for each machine/paddle combination was calculated. RESULTS: All machine/paddle combinations demonstrate highest levels of motion during the first 10 s of the clamping phase. The least motion is 0.17 ± 0.05 mm/10 s (n = 20) and the most motion is 0.51 ± 0.15 mm/10 s (n = 80). There is a statistical difference in paddle motion between fixed and flexible (p < 0.001), GE Senographe Essential and Hologic Selenia Dimensions paddles (p < 0.001). Paddle tilt in the medial-lateral plane is independent of time and varied from 0.04 ° to 0.69 °. CONCLUSION: All machine/paddle combinations exhibited motion and tilting, and the extent varied with machine and paddle sizes and types. ADVANCES IN KNOWLEDGE: This research suggests that image blurring will likely be clinically insignificant 4 s or more after the clamping phase commences.

Cumulative radiation exposure and associated cancer risk estimates for scoliosis patients: Impact of repetitive full spine radiography.

OBJECTIVE: To quantitatively evaluate the cumulative effective dose and associated cancer risk for scoliotic patients undergoing repetitive full spine radiography during their diagnosis and follow up periods. METHODS: Organ absorbed doses of full spine exposed scoliotic patients at different age were computer simulated with the use of PCXMC software. Gender specific effective dose was then calculated with the ICRP-103 approach. Values of lifetime attributable cancer risk for patients exposed at different age were calculated for both patient genders and for Asian and Western population. Mathematical fitting for effective dose and for lifetime attributable cancer risk, as function of exposed age, was analytically obtained to quantitatively estimate patient cumulated effective dose and cancer risk. RESULTS: The cumulative effective dose of full spine radiography with posteroanterior and lateral projection for patients exposed annually at age between 5 and 30 years using digital radiography system was calculated as 15mSv. The corresponding cumulative lifetime attributable cancer risk for Asian and Western population was calculated as 0.08-0.17%. Female scoliotic patients would be at a statistically significant higher cumulated cancer risk than male patients under the same full spine radiography protocol. CONCLUSION: We demonstrate the use of computer simulation and analytic formula to quantitatively obtain the cumulated effective dose and cancer risk at any age of exposure, both of which are valuable information to medical personnel and patients' parents concern about radiation safety in repetitive full spine radiography.