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1.
Regulation of acetylcholinesterase during the lipopolysaccharide-induced inflammatory responses in microglial cells.
FASEB J
; 36(3): e22189, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35129858
2.
Tacrine Induces Endoplasmic Reticulum-Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells.
Mol Pharmacol
; 100(5): 456-469, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34531295
3.
Promising tacrine/huperzine A-based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget.
J Neurochem
; 158(6): 1381-1393, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33930191
4.
Tacrine(10)-hupyridone, a dual-binding acetylcholinesterase inhibitor, potently attenuates scopolamine-induced impairments of cognition in mice.
Metab Brain Dis
; 33(4): 1131-1139, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29564727
5.
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3ß and the ERK Pathway.
Cell Mol Neurobiol
; 37(4): 655-664, 2017 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-27412761
6.
Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo.
Eur J Pharmacol
; 883: 173361, 2020 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32673674
7.
Interacting with α 7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages.
Acta Pharm Sin B
; 10(10): 1926-1942, 2020 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-33163344
8.
Multifunctional memantine nitrate significantly protects against glutamate-induced excitotoxicity via inhibiting calcium influx and attenuating PI3K/Akt/GSK3beta pathway.
Chem Biol Interact
; 325: 109020, 2020 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32092300
9.
Significant combination of Aß aggregation inhibitory and neuroprotective properties in silico, in vitro and in vivo by bis(propyl)-cognitin, a multifunctional anti-Alzheimer's agent.
Eur J Pharmacol
; 876: 173065, 2020 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32171792
10.
Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in Vitro and in Vivo.
ACS Chem Neurosci
; 11(3): 314-327, 2020 02 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31922720
11.
Shexiang Baoxin Pill, a Traditional Chinese Herbal Formula, Rescues the Cognitive Impairments in APP/PS1 Transgenic Mice.
Front Pharmacol
; 11: 1045, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32765267
12.
Bis(propyl)-cognitin potentiates rehabilitation of treadmill exercise after a transient focal cerebral ischemia, possibly via inhibiting NMDA receptor and regulating VEGF expression.
Neurochem Int
; 128: 143-153, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31034915
13.
Correction to "Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in Vitro and in Vivo".
ACS Chem Neurosci
; 15(10): 2089-2090, 2024 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38679870
14.
The dual-functional memantine nitrate MN-08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models.
Br J Pharmacol
; 176(17): 3318-3335, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31180578
15.
Research and development of anti-Alzheimer's disease drugs: an update from the perspective of technology flows.
Expert Opin Ther Pat
; 28(4): 341-350, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29421930
16.
Neuroprotection Against MPP+-Induced Cytotoxicity Through the Activation of PI3-K/Akt/GSK3ß/MEF2D Signaling Pathway by Rhynchophylline, the Major Tetracyclic Oxindole Alkaloid Isolated From Uncaria rhynchophylla.
Front Pharmacol
; 9: 768, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30072894
17.
A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor.
Front Pharmacol
; 9: 73, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29483871
18.
Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice.
Front Cell Neurosci
; 12: 396, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30483056
19.
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B.
Neuropharmacology
; 126: 12-24, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28807675
20.
Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models.
Neurochem Int
; 99: 194-205, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27445088