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1.
Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.
Bioorg Med Chem Lett
; 21(9): 2725-31, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21183342
2.
Short-Term Efficacy Reliably Predicts Long-Term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-Based Meta-Analysis.
J Clin Pharmacol
; 56(7): 835-44, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26517752
3.
A model-based dose-response meta-analysis of ocular hypotensive agents as a drug development tool to evaluate new therapies in glaucoma.
J Ocul Pharmacol Ther
; 31(4): 189-97, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25714918
4.
Pharmacokinetics of melagatran and the effect on ex vivo coagulation time in orthopaedic surgery patients receiving subcutaneous melagatran and oral ximelagatran: a population model analysis.
Clin Pharmacokinet
; 42(7): 687-701, 2003.
Artículo
en Inglés
| MEDLINE | ID: mdl-12844328
5.
Similar relationship between the time course of bone mineral density improvement and vertebral fracture risk reduction with denosumab treatment in postmenopausal osteoporosis and prostate cancer patients on androgen deprivation therapy.
J Clin Pharmacol
; 54(5): 503-12, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24214315
6.
Time course of bone mineral density changes with denosumab compared with other drugs in postmenopausal osteoporosis: a dose-response-based meta-analysis.
J Clin Endocrinol Metab
; 99(10): 3746-55, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24915115
7.
Model-based development of gemcabene, a new lipid-altering agent.
AAPS J
; 7(3): E513-22, 2005 Oct 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-16353929
8.
The use of clinical trial simulation to support dose selection: application to development of a new treatment for chronic neuropathic pain.
Pharm Res
; 20(11): 1752-9, 2003 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-14661918
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