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1.

Regulation of GTPase function by autophosphorylation.

Johnson, Christian W; Seo, Hyuk-Soo; Terrell, Elizabeth M; Yang, Moon-Hee; KleinJan, Fenneke; Gebregiworgis, Teklab; Gasmi-Seabrook, Genevieve M C; Geffken, Ezekiel A; Lakhani, Jimit; Song, Kijun; Bashyal, Puspalata; Popow, Olesja; Paulo, Joao A; Liu, Andrea; Mattos, Carla; Marshall, Christopher B; Ikura, Mitsuhiko; Morrison, Deborah K; Dhe-Paganon, Sirano; Haigis, Kevin M.

Mol Cell ; 82(5): 950-968.e14, 2022 03 03.

Artículo en Inglés | MEDLINE | ID: mdl-35202574

2.

Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3.

Saitoh, Takashi; Kim, Ha-Neul; Narita, Riku; Ohtsuka, Ibuki; Mo, Weiyu; Lee, Ki-Young; Enomoto, Masahiro; Gasmi-Seabrook, Geneviève M C; Marshall, Christopher B; Ikura, Mitsuhiko.

Protein Expr Purif ; 212: 106361, 2023 12.

Artículo en Inglés | MEDLINE | ID: mdl-37652393

3.

Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane.

Fang, Zhenhao; Lee, Ki-Young; Huo, Ku-Geng; Gasmi-Seabrook, Geneviève; Zheng, Le; Moghal, Nadeem; Tsao, Ming-Sound; Ikura, Mitsuhiko; Marshall, Christopher B.

Proc Natl Acad Sci U S A ; 117(22): 12101-12108, 2020 06 02.

Artículo en Inglés | MEDLINE | ID: mdl-32414921

4.

The Self-Association of the KRAS4b Protein is Altered by Lipid-Bilayer Composition and Electrostatics.

Lee, Ki-Young; Ikura, Mitsuhiko; Marshall, Christopher B.

Angew Chem Int Ed Engl ; 62(18): e202218698, 2023 04 24.

Artículo en Inglés | MEDLINE | ID: mdl-36883374

5.

NMR in integrated biophysical drug discovery for RAS: past, present, and future.

Marshall, Christopher B; KleinJan, Fenneke; Gebregiworgis, Teklab; Lee, Ki-Young; Fang, Zhenhao; Eves, Ben J; Liu, Ningdi F; Gasmi-Seabrook, Geneviève M C; Enomoto, Masahiro; Ikura, Mitsuhiko.

J Biomol NMR ; 74(10-11): 531-554, 2020 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-32804298

6.

Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition.

Meiri, David; Marshall, Christopher B; Greeve, Melissa A; Kim, Bryan; Balan, Marc; Suarez, Fernando; Bakal, Chris; Wu, Chuanjin; Larose, Jose; Fine, Noah; Ikura, Mitsuhiko; Rottapel, Robert.

Mol Cell ; 45(5): 642-55, 2012 Mar 09.

Artículo en Inglés | MEDLINE | ID: mdl-22405273

7.

A Non-Canonical Calmodulin Target Motif Comprising a Polybasic Region and Lipidated Terminal Residue Regulates Localization.

Grant, Benjamin M M; Enomoto, Masahiro; Ikura, Mitsuhiko; Marshall, Christopher B.

Int J Mol Sci ; 21(8)2020 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-32326637

8.

Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement.

Lee, Ki-Young; Fang, Zhenhao; Enomoto, Masahiro; Gasmi-Seabrook, Genevieve; Zheng, Le; Koide, Shohei; Ikura, Mitsuhiko; Marshall, Christopher B.

Angew Chem Int Ed Engl ; 59(27): 11037-11045, 2020 06 26.

Artículo en Inglés | MEDLINE | ID: mdl-32227412

9.

Multiple Calmodulin-Binding Sites Positively and Negatively Regulate Arabidopsis CYCLIC NUCLEOTIDE-GATED CHANNEL12.

DeFalco, Thomas A; Marshall, Christopher B; Munro, Kim; Kang, Hong-Gu; Moeder, Wolfgang; Ikura, Mitsuhiko; Snedden, Wayne A; Yoshioka, Keiko.

Plant Cell ; 28(7): 1738-51, 2016 07.

Artículo en Inglés | MEDLINE | ID: mdl-27335451

10.

Hitting the hotspots.

Marshall, Christopher B; Ikura, Mitsuhiko.

Nat Chem Biol ; 18(6): 578-579, 2022 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-35314815

11.

Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids.

Gebregiworgis, Teklab; Marshall, Christopher B; Nishikawa, Tadateru; Radulovich, Nikolina; Sandí, María-José; Fang, Zhenhao; Rottapel, Robert; Tsao, Ming-Sound; Ikura, Mitsuhiko.

J Am Chem Soc ; 140(13): 4473-4476, 2018 04 04.

Artículo en Inglés | MEDLINE | ID: mdl-29543440

12.

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.

Mazhab-Jafari, Mohammad T; Marshall, Christopher B; Smith, Matthew J; Gasmi-Seabrook, Geneviève M C; Stathopulos, Peter B; Inagaki, Fuyuhiko; Kay, Lewis E; Neel, Benjamin G; Ikura, Mitsuhiko.

Proc Natl Acad Sci U S A ; 112(21): 6625-30, 2015 May 26.

Artículo en Inglés | MEDLINE | ID: mdl-25941399

13.

Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).

Fang, Zhenhao; Marshall, Christopher B; Yin, Jiani C; Mazhab-Jafari, Mohammad T; Gasmi-Seabrook, Geneviève M C; Smith, Matthew J; Nishikawa, Tadateru; Xu, Yang; Neel, Benjamin G; Ikura, Mitsuhiko.

J Biol Chem ; 291(30): 15641-52, 2016 07 22.

Artículo en Inglés | MEDLINE | ID: mdl-27226556

14.

Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).

Mazhab-Jafari, Mohammad T; Marshall, Christopher B; Ho, Jason; Ishiyama, Noboru; Stambolic, Vuk; Ikura, Mitsuhiko.

J Biol Chem ; 289(18): 12195-201, 2014 May 02.

Artículo en Inglés | MEDLINE | ID: mdl-24648513

15.

Calmodulin and STIM proteins: Two major calcium sensors in the cytoplasm and endoplasmic reticulum.

Marshall, Christopher B; Nishikawa, Tadateru; Osawa, Masanori; Stathopulos, Peter B; Ikura, Mitsuhiko.

Biochem Biophys Res Commun ; 460(1): 5-21, 2015 Apr 24.

Artículo en Inglés | MEDLINE | ID: mdl-25998729

16.

Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.

Wang, Feng; Marshall, Christopher B; Yamamoto, Kazuo; Li, Guang-Yao; Gasmi-Seabrook, Geneviève M C; Okada, Hitoshi; Mak, Tak W; Ikura, Mitsuhiko.

Proc Natl Acad Sci U S A ; 109(16): 6078-83, 2012 Apr 17.

Artículo en Inglés | MEDLINE | ID: mdl-22474372

17.

Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.

Wang, Feng; Marshall, Christopher B; Ikura, Mitsuhiko.

Cell Mol Life Sci ; 70(21): 3989-4008, 2013 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-23307074

18.

Reconstitution and characterization of BRAF in complex with 14-3-3 and KRAS4B on nanodiscs.

Liu, Ningdi F; Enomoto, Masahiro; Marshall, Christopher B; Ikura, Mitsuhiko.

Protein Sci ; 33(6): e5016, 2024 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-38747381

19.

Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II.

Gebregiworgis, Teklab; Chan, Jonathan Yui-Lai; Kuntz, Douglas A; Privé, Gilbert G; Marshall, Christopher B; Ikura, Mitsuhiko.

Eur J Cell Biol ; 103(2): 151414, 2024 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-38640594

20.

Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc.

Mazhab-Jafari, Mohammad T; Marshall, Christopher B; Stathopulos, Peter B; Kobashigawa, Yoshihiro; Stambolic, Vuk; Kay, Lewis E; Inagaki, Fuyuhiko; Ikura, Mitsuhiko.

J Am Chem Soc ; 135(9): 3367-70, 2013 Mar 06.

Artículo en Inglés | MEDLINE | ID: mdl-23409921

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