1.
Org Biomol Chem
; 19(9): 1945-1949, 2021 03 11.
Artículo
en Inglés
| MEDLINE
| ID: mdl-33595577
RESUMEN
The reaction between configurably stable α-lithiated oxiranes and 3-substituted cyclobutanones allows obtaining enantiomerically enriched cyclobutanols (er > 98 : 2). These adducts, subjected to base-mediated Payne rearrangement, lead to the synthesis of a new class of oxaspirohexanes, useful precursors of 2,4-disubstituted cyclopentanones.