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1.

In vitro platform to model the function of ionocytes in the human airway epithelium.

Vilà-González, Marta; Pinte, Laetitia; Fradique, Ricardo; Causa, Erika; Kool, Heleen; Rodrat, Mayuree; Morell, Carola Maria; Al-Thani, Maha; Porter, Linsey; Guo, Wenrui; Maeshima, Ruhina; Hart, Stephen L; McCaughan, Frank; Granata, Alessandra; Sheppard, David N; Floto, R Andres; Rawlins, Emma L; Cicuta, Pietro; Vallier, Ludovic.

Respir Res ; 25(1): 180, 2024 Apr 25.

Artículo en Inglés | MEDLINE | ID: mdl-38664797

2.

SOX2 and squamous cancers.

Porter, Linsey; McCaughan, Frank.

Semin Cancer Biol ; 67(Pt 1): 154-167, 2020 12.

Artículo en Inglés | MEDLINE | ID: mdl-32905832

3.

Assessment of Minimal Residual Disease in Standard-Risk AML.

Ivey, Adam; Hills, Robert K; Simpson, Michael A; Jovanovic, Jelena V; Gilkes, Amanda; Grech, Angela; Patel, Yashma; Bhudia, Neesa; Farah, Hassan; Mason, Joanne; Wall, Kerry; Akiki, Susanna; Griffiths, Michael; Solomon, Ellen; McCaughan, Frank; Linch, David C; Gale, Rosemary E; Vyas, Paresh; Freeman, Sylvie D; Russell, Nigel; Burnett, Alan K; Grimwade, David.

N Engl J Med ; 374(5): 422-33, 2016 Feb 04.

Artículo en Inglés | MEDLINE | ID: mdl-26789727

4.

SOX2 Drives Bronchial Dysplasia in a Novel Organotypic Model of Early Human Squamous Lung Cancer.

Correia, Lúcia L; Johnson, Jo-Anne; McErlean, Peter; Bauer, Julien; Farah, Hassan; Rassl, Doris M; Rintoul, Robert C; Sethi, Tariq; Lavender, Paul; Rawlins, Emma L; Littlewood, Trevor D; Evan, Gerard I; McCaughan, Frank M.

Am J Respir Crit Care Med ; 195(11): 1494-1508, 2017 06 01.

Artículo en Inglés | MEDLINE | ID: mdl-28199128

5.

Cell migration leads to spatially distinct but clonally related airway cancer precursors.

Pipinikas, Christodoulos P; Kiropoulos, Theodoros S; Teixeira, Vitor H; Brown, James M; Varanou, Aikaterini; Falzon, Mary; Capitanio, Arrigo; Bottoms, Steven E; Carroll, Bernadette; Navani, Neal; McCaughan, Frank; George, Jeremy P; Giangreco, Adam; Wright, Nicholas A; McDonald, Stuart A C; Graham, Trevor A; Janes, Sam M.

Thorax ; 69(6): 548-57, 2014 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-24550057

6.

Digital PCR strategies in the development and analysis of molecular biomarkers for personalized medicine.

Day, Elizabeth; Dear, Paul H; McCaughan, Frank.

Methods ; 59(1): 101-7, 2013 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-22926236

7.

A Conformable Organic Electronic Device for Monitoring Epithelial Integrity at the Air Liquid Interface.

Barron, Sarah L; Oldroyd, Sophie V; Saez, Janire; Chernaik, Alice; Guo, Wenrui; McCaughan, Frank; Bulmer, David; Owens, Róisín M.

Adv Mater ; 36(8): e2306679, 2024 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-38061027

8.

IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer.

Day, Elizabeth; Poulogiannis, George; McCaughan, Frank; Mulholland, Shani; Arends, Mark J; Ibrahim, Ashraf E K; Dear, Paul H.

Int J Exp Pathol ; 94(3): 203-11, 2013 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-23594372

9.

Single-molecule analysis of genome rearrangements in cancer.

Pole, Jessica C M; McCaughan, Frank; Newman, Scott; Howarth, Karen D; Dear, Paul H; Edwards, Paul A W.

Nucleic Acids Res ; 39(13): e85, 2011 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-21525129

10.

Cigarette smoke preferentially induces full length ACE2 expression in differentiated primary human airway cultures but does not alter the efficiency of cellular SARS-CoV-2 infection.

Porter, Linsey M; Guo, Wenrui; Crozier, Thomas Wm; Greenwood, Edward Jd; Ortmann, Brian; Kottmann, Daniel; Nathan, James A; Mahadeva, Ravindra; Lehner, Paul J; McCaughan, Frank.

Heliyon ; 9(3): e14383, 2023 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-36938474

11.

Genomic evidence of pre-invasive clonal expansion, dispersal and progression in bronchial dysplasia.

McCaughan, Frank; Pipinikas, Christodoulos P; Janes, Sam M; George, P Jeremy; Rabbitts, Pamela H; Dear, Paul H.

J Pathol ; 224(2): 153-9, 2011 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-21506132

12.

Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures.

Guo, Wenrui; Porter, Linsey M; Crozier, Thomas Wm; Coates, Matthew; Jha, Akhilesh; McKie, Mikel; Nathan, James A; Lehner, Paul J; Greenwood, Edward Jd; McCaughan, Frank.

Life Sci Alliance ; 5(4)2022 04.

Artículo en Inglés | MEDLINE | ID: mdl-35110354

13.

Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasion.

Crozier, Thomas W M; Greenwood, Edward J D; Williamson, James C; Guo, Wenrui; Porter, Linsey M; Gabaev, Ildar; Teixeira-Silva, Ana; Grice, Guinevere L; Wickenhagen, Arthur; Stanton, Richard J; Wang, Eddie C Y; Wilson, Sam J; Matheson, Nicholas J; Nathan, James A; McCaughan, Frank; Lehner, Paul J.

Wellcome Open Res ; 7: 224, 2022.

Artículo en Inglés | MEDLINE | ID: mdl-36483314

14.

Single-molecule genomics.

McCaughan, Frank; Dear, Paul H.

J Pathol ; 220(2): 297-306, 2010 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-19927313

15.

Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer.

McCaughan, Frank; Pole, Jessica C M; Bankier, Alan T; Konfortov, Bernard A; Carroll, Bernadette; Falzon, Mary; Rabbitts, Terence H; George, P Jeremy; Dear, Paul H; Rabbitts, Pamela H.

Am J Respir Crit Care Med ; 182(1): 83-91, 2010 Jul 01.

Artículo en Inglés | MEDLINE | ID: mdl-20299530

16.

Identification of SARS-CoV-2-induced pathways reveals drug repurposing strategies.

Han, Namshik; Hwang, Woochang; Tzelepis, Konstantinos; Schmerer, Patrick; Yankova, Eliza; MacMahon, Méabh; Lei, Winnie; M Katritsis, Nicholas; Liu, Anika; Felgenhauer, Ulrike; Schuldt, Alison; Harris, Rebecca; Chapman, Kathryn; McCaughan, Frank; Weber, Friedemann; Kouzarides, Tony.

Sci Adv ; 7(27)2021 06.

Artículo en Inglés | MEDLINE | ID: mdl-34193418

17.

The SARS-CoV-2 viral load in COVID-19 patients is lower on face mask filters than on nasopharyngeal swabs.

Smolinska, Agnieszka; Jessop, David S; Pappan, Kirk L; De Saedeleer, Alexandra; Kang, Amerjit; Martin, Alexandra L; Allsworth, Max; Tyson, Charlotte; Bos, Martine P; Clancy, Matt; Morel, Mike; Cooke, Tony; Dymond, Tom; Harris, Claire; Galloway, Jacqui; Bresser, Paul; Dijkstra, Nynke; Jagesar, Viresh; Savelkoul, Paul H M; Beuken, Erik V H; Nix, Wesley H V; Louis, Renaud; Delvaux, Muriel; Calmes, Doriane; Ernst, Benoit; Pollini, Simona; Peired, Anna; Guiot, Julien; Tomassetti, Sara; Budding, Andries E; McCaughan, Frank; Marciniak, Stefan J; van der Schee, Marc P.

Sci Rep ; 11(1): 13476, 2021 06 29.

Artículo en Inglés | MEDLINE | ID: mdl-34188082

18.

BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma.

Lazarus, Kyren A; Hadi, Fazal; Zambon, Elisabetta; Bach, Karsten; Santolla, Maria-Francesca; Watson, Julie K; Correia, Lucia L; Das, Madhumita; Ugur, Rosemary; Pensa, Sara; Becker, Lukas; Campos, Lia S; Ladds, Graham; Liu, Pentao; Evan, Gerard I; McCaughan, Frank M; Le Quesne, John; Lee, Joo-Hyeon; Calado, Dinis; Khaled, Walid T.

Nat Commun ; 9(1): 3327, 2018 08 20.

Artículo en Inglés | MEDLINE | ID: mdl-30127402

19.

MET-EGFR dimerization in lung adenocarcinoma is dependent on EGFR mtations and altered by MET kinase inhibition.

Ortiz-Zapater, Elena; Lee, Richard W; Owen, William; Weitsman, Gregory; Fruhwirth, Gilbert; Dunn, Robert G; Neat, Michael J; McCaughan, Frank; Parker, Peter; Ng, Tony; Santis, George.

PLoS One ; 12(1): e0170798, 2017.

Artículo en Inglés | MEDLINE | ID: mdl-28141869

20.

RORÎ³t⁺ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers.

Irshad, Sheeba; Flores-Borja, Fabian; Lawler, Katherine; Monypenny, James; Evans, Rachel; Male, Victoria; Gordon, Peter; Cheung, Anthony; Gazinska, Patrycja; Noor, Farzana; Wong, Felix; Grigoriadis, Anita; Fruhwirth, Gilbert O; Barber, Paul R; Woodman, Natalie; Patel, Dominic; Rodriguez-Justo, Manuel; Owen, Julie; Martin, Stewart G; Pinder, Sarah E; Gillett, Cheryl E; Poland, Simon P; Ameer-Beg, Simon; McCaughan, Frank; Carlin, Leo M; Hasan, Uzma; Withers, David R; Lane, Peter; Vojnovic, Borivoj; Quezada, Sergio A; Ellis, Paul; Tutt, Andrew N J; Ng, Tony.

Cancer Res ; 77(5): 1083-1096, 2017 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-28082403

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