1.
Angew Chem Int Ed Engl
; 57(32): 10314-10317, 2018 Aug 06.
Artículo
en Inglés
| MEDLINE
| ID: mdl-29863302
RESUMEN
A bulky carboxylic acid bearing three cyclohexylmethyl substituents at the α-position, namely, tri(cyclohexylmethyl)acetic acid, is demonstrated to act as an efficient ligand source in Pd-catalyzed intramolecular C(sp2 )-H and C(sp3 )-H arylation reactions. The reactions proceed smoothly under mild reaction conditions, even at room temperature due to the steric bulk of the carboxylate ligands, which accelerates the rate-determining C-H bond activation step in the catalytic cycle.