Detalles de la búsqueda
1.
Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling.
Mol Cell
; 59(3): 345-358, 2015 Aug 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-26145173
2.
Role of VMH ketone bodies in adjusting caloric intake to increased dietary fat content in DIO and DR rats.
Am J Physiol Regul Integr Comp Physiol
; 308(10): R872-8, 2015 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25786485
3.
Inhibition of bacterial mevalonate diphosphate decarboxylase by eriochrome compounds.
Arch Biochem Biophys
; 566: 1-6, 2015 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25499551
4.
Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an archaeal alternate mevalonate pathway.
J Bacteriol
; 196(5): 1055-63, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24375100
5.
Expression in Haloferax volcanii of 3-hydroxy-3-methylglutaryl coenzyme A synthase facilitates isolation and characterization of the active form of a key enzyme required for polyisoprenoid cell membrane biosynthesis in halophilic archaea.
J Bacteriol
; 195(17): 3854-62, 2013 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23794621
6.
Identification and characterization of an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase.
J Biol Chem
; 287(40): 33227-36, 2012 Sep 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-22865860
7.
Molecular docking and NMR binding studies to identify novel inhibitors of human phosphomevalonate kinase.
Biochem Biophys Res Commun
; 430(1): 313-9, 2013 Jan 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-23146631
8.
Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase.
Biochemistry
; 51(28): 5611-21, 2012 Jul 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-22734632
9.
Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin.
Biochemistry
; 51(23): 4713-22, 2012 Jun 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22510038
10.
Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis.
J Biol Chem
; 286(27): 23900-10, 2011 Jul 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-21561869
11.
Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase.
J Infect Dis
; 204(4): 609-16, 2011 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21791663
12.
Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J Biol Chem
; 285(34): 26341-9, 2010 Aug 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-20558737
13.
Enzymes of the mevalonate pathway of isoprenoid biosynthesis.
Arch Biochem Biophys
; 505(2): 131-43, 2011 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20932952
14.
Influence of multiple cysteines on human 3-hydroxy-3-methylglutaryl-CoA lyase activity and formation of inter-subunit adducts.
Arch Biochem Biophys
; 511(1-2): 48-55, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21514269
15.
NMR dynamics investigation of ligand-induced changes of main and side-chain arginine N-H's in human phosphomevalonate kinase.
J Am Chem Soc
; 132(7): 2102-3, 2010 Feb 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-20112895
16.
A visible wavelength spectrophotometric assay suitable for high-throughput screening of 3-hydroxy-3-methylglutaryl-CoA synthase.
Anal Biochem
; 396(1): 96-102, 2010 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19706283
17.
Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism.
Proteins
; 75(1): 127-38, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-18798562
18.
Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure.
Arch Biochem Biophys
; 480(1): 58-67, 2008 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18823933
19.
Functional contribution of a conserved, mobile loop histidine of phosphoribulokinase.
Protein Sci
; 15(4): 837-42, 2006 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-16522805
20.
Active site binding modes of inhibitors of Staphylococcus aureus mevalonate diphosphate decarboxylase from docking and molecular dynamics simulations.
J Mol Model
; 22(1): 13, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26680991