The effects of fenugreek seed extract supplementation in patients with Alzheimer's disease: A randomized, double-blind, placebo-controlled trial.

The aim of the current randomized control trial (RCT) study was to investigate the effects of fenugreek seed extract on memory, depression, quality of life, blood pressure, and serum malondialdehyde (MDA) and total antioxidant capacity (TAC) levels in adult AD patients. This randomized clinical trial was conducted in geriatric homes in Iran. The study participants included 82 AD patients with mild-to-moderate memory deficit. Patients in the intervention group received 5 cc of fenugreek seed extract for 4 months and subjects in the control group received a placebo. Memory, depression, quality of life, and BP levels, as well as serum MDA and TAC, were assessed before and after the intervention. There was a significant increase in serum levels of TAC (p < 0.001) and a reduction in serum MDA status (p < 0.001) after 4 months of fenugreek seed extract supplementation. In addition, increasing levels of memory (p < 0.001) and quality of life (p < 0.001), as well as reduction of depression (p = 0.002), systolic BP (p < 0.001), and diastolic BP (p < 0.001) levels were detected in the intervention group compared with baseline. Fenugreek seed extract supplementation in AD patients shows promising positive effects on memory, quality of life, BP, and selective oxidative indices levels.

Geographical distribution of Anthrax using Geographic Information System (GIS) during 2010-2015 in Iran.

Background: Anthrax is a zoonotic infectious disease that is still considered as a health problem in developing countries. Therefore, the aim of this study was to investigate the incidence and geographical distribution of anthrax using the Geographic Information System (GIS) and predict its incidence in Iran in 2021. Methods: This study is descriptive analytical study. Information on anthrax was obtained from the Center for Communicable Diseases Control during 2010-2015. In the next step, ArcGIS 9.3 was used to prepare geographic maps of the disease incidence and frequency. Therefore, using the Raster Calculator tool, the disease prediction map was drawn. Results: The highest incidence of anthrax during 2010-2015 was observed in the provinces of Kurdistan, North Khorasan, and Chaharmahal and Bakhtiari, respectively. The trend of the incidence of anthrax in Iran had increased from 2010 to 2013, while its incidence decreased in 2014. Based on the results of modeling in Iran, the provinces of Kurdistan, West Azarbaijan, Tehran, and Zanjan, respectively, with 37.16%, 33.83%, 16.78%, and 10.49% of their area (km2) had the highest risk of anthrax disease in the country in the year 2021. Conclusion: Since the provinces of Kurdistan, West Azerbaijan, Tehran, and Zanjan are among the high-risk areas in the country in the coming years, the cooperation between the veterinary organization and the health care system and the vaccination of livestock in these areas can significantly help to control and prevent the disease.

The Incidence and Geographical Distribution of Brucellosis in Iran Using Geographic Information System and Prediction of its Incidence in 2021.

BACKGROUND: Brucellosis is one of the most challenging health issues in many developing countries including Iran. The purpose of this study is to investigate the incidence and geographical distribution of brucellosis using Geographic Information System (GIS) and to predict its incidence in Iran in 2021. METHOD: This is a descriptive-analytical cross-sectional study, which contains spatial and climatic information along with the prevalence rate of brucellosis in Iran. Disease information was obtained from the National Center for Infectious Diseases Management during 2011-2015. Then, Arc GIS version 9.3 was used to plot the geographical maps for the incidence and frequency of the disease. Using the Raster calculator tool, the disease prediction map for the future was plotted. For proper spatial distribution of hot and cold spots, Getis-Ord-Gi statistic was employed. FINDINGS: The highest incidence of brucellosis during 2009-2015 was observed in the western provinces of Iran (North Khorasan, South Khorasan and Razavi Khorasan provinces). The incidence of brucellosis in Iran decreased from 2009 to 2011 but it exhibited an increasing trend from 2011 to 2014. The provinces of Kurdistan, Lorestan, Ilam, Zanjan and Kermanshah may be among the hot spots in terms of brucellosis incidence in 2021. CONCLUSION: We predicted significant variations in brucellosis risk distribution in Iran in the coming years. In the western and northwestern provinces, which are among the high risk areas for the incidence of this disease in the future, this disease can pose a serious health threat to the residents of these areas.

Risk Factors Associated with Low Birth Weight Among Infants: A Nested Case-Control Study in Southeastern Iran.

BACKGROUND: Mortality rate in low-birth-weight infants is almost 30 times more than that in those with normal weight, so the birth of low-birth-weight infants is one of the most serious health problems in the world. Therefore, this nested case-control study was conducted to investigate the risk factors associated with low birth weight among infants in the rural population of Kerman province. METHODS: This nested case-control study was performed in rural areas of Kerman province, southeastern Iran. Case (n = 155) and control (n = 310) groups were selected using risk set sampling. Data were analyzed through Point and distance estimation (OR, CI) using conditional logistic regression method by Stata-12 software. RESULTS: The results of multivariate analysis showed that maternal BMI [OR = 0.3, CI 95% (0.1, 0.9)], gestational age [OR = 3.8, CI 95% (0.9, 6.1)], history of stillbirth [OR = 4.8, CI 95% (1.3, 11)], history of pregnancy bleeding [OR = 3.7, CI 95% (0.7, 9)], pregnancy craving [OR = 3, CI 95% (1.1, 3.8)], and the level of health workers' care [OR = 0.4, CI 95% (0.1, 0.9)] are the risk factors affecting LBW in infants (P < 0.05). CONCLUSIONS: Low birth weight is a multifactorial phenomenon. Therefore, raising public awareness, providing nutritional counseling to pregnant mothers, regular referral to health homes to receive health care, and identifying risk factors and referral to higher level specialists and health centers can be effective in reducing the risk of birth of LBW infants.

Knowledge and Attitude of Iranian Youth Toward AIDS: A Systematic Review and Meta-Analysis in Iran.

Inadequate knowledge and negative attitudes are the major hindrances to prevent the spread of the human immunodeficiency virus. This study aims to assess the knowledge and attitude toward the human immunodeficiency virus and acquired immune deficiency syndrome among youths in Iran. We conducted a systematic review, searching online databases until July 2018, focusing on knowledge and attitudes about the human immunodeficiency virus and acquired immune deficiency syndrome in Iranian youths. We included the studies that aimed to determine the knowledge and attitudes of people from Iran and were conducted in the last 18 years. In total, 14 eligible papers (out of 300) were entered into the analysis, and the overall knowledge of Iranian youth toward the acquired immune deficiency syndrome was 57.6% (95% CI: 56.7%-58.5%). Also, the results of Cochran's test showed the heterogeneity of the studies (Q=1578.2, df=13, I2=79.4%, p<0.001). We concluded that our results would guide the development of population-focused knowledge and attitude about the human immunodeficiency virus and acquired immune deficiency syndrome in Iran, which is lacking among the general public and healthcare staff.

Sexual Desire and Related Factors in Middle-Aged and Elderly Married Women: A Cross-Sectional Study in Iran.

BACKGROUND: The sexual desire in the middle-aged and senior women is one of the factors affecting their quality of life and psychological well-being. AIM: The present study was aimed to assess the sexual desire and related factors among married women aged 50-70 years. MATERIALS AND METHODS: In this descriptive-analytical study, 210 married menopausal women aged 50-70 years were selected by cluster sampling method. Data were collected using a demographic profile questionnaire and Sexual Desire Inventory (SDI), and analysed by SPSS version 22 software using descriptive statistics and independent t-test, ANOVA and Pearson correlation coefficient tests. RESULTS: The mean age of women was 59.40 ± 5.93 years, and the mean sexual desire score was 22.66 ± 17.78 (out of 112). There was a significant relationship between sexual desire score and age, educational level, occupation of women and spouses, age of menopause, marital history, number of pregnancies and children, individual health and pain level (P < 0.001). The sexual desire score had a significant association with diabetes, hypertension, heart disease, high cholesterol, chronic pain, gastrointestinal problems, chronic ulcers, bladder and intestinal problems, joint and bone disorders, taking cardiac medications, antihypertensive, anticoagulant, insulin, cholesterol-lowering drugs (P < 0.001). CONCLUSION: The low sexual desire score and its reduction with age and the presence of various diseases and factors affecting sexual desire highlight the importance of diagnostic screening, family related educational planning and the role of health care providers in the health status of the older adults.