Inhibited postprandial retrograde cyclic motor pattern in the distal colon of patients with diarrhea-predominant irritable bowel syndrome.

Patients with irritable bowel syndrome (IBS) have recurrent lower abdominal pain, associated with altered bowel habit (diarrhea and/or constipation). As bowel habit is altered, abnormalities in colonic motility are likely to contribute; however, characterization of colonic motor patterns in patients with IBS remains poor. Utilizing fiber-optic manometry, we aimed to characterize distal colonic postprandial colon motility in diarrhea-predominant IBS. After an overnight fast, a 72-sensor (spaced at 1-cm intervals) manometry catheter was colonoscopically placed to the proximal colon, in 13 patients with IBS-D and 12 healthy adults. Recordings were taken for 2 h pre and post a 700 kcal meal. Data were analyzed with our two developed automated techniques. In both healthy adults and patients with IBS-D, the dominant frequencies of pressure waves throughout the colon are between 2 and 4 cycles per minute (cpm) and the power of these frequencies increased significantly after a meal. Although these pressure waves formed propagating contractions in both groups, the postprandial propagating contraction increase was significantly smaller in patients compared with healthy adults. In healthy adults during the meal period, retrograde propagation between 2 and 8 cpm was significantly greater than antegrade propagation at the same frequencies. This difference was not observed in IBS-D. Patients with IBS-D show reduced prevalence of the retrograde cyclic motor pattern postprandially compared with the marked prevalence in healthy adults. We hypothesize that this reduction may allow premature rectal filling, leading to postprandial urgency and diarrhea.NEW & NOTEWORTHY Compared with healthy adults this study has shown a significant reduction in the prevalence of the postprandial retrograde cyclic motor pattern in the distal colon of patients with diarrhea-predominant irritable bowel syndrome. We hypothesize that this altered motility may allow for premature rectal filling which contributes to the postprandial urgency and diarrhea experienced by these patients.

Migrated Laparoscopic Surgical Clips Causing Acute Cholangitis 32 Years After Laparoscopic Cholecystectomy.

Surgical clip migration post-laparoscopic cholecystectomy is a rare but important complication to consider in patients presenting with biliary obstruction. Titanium surgical clips are widely used in laparoscopic surgery to ligate vessels and ducts and are particularly important in laparoscopic cholecystectomy to ligate the cystic duct. More common complications associated with clips involve dislodgement, however, there are reported cases of migration into visceral structures causing an obstruction. We describe a case that demonstrated an acute migration of surgical clips into the common bile duct (CBD) within a three-week period, which occurred 32 years after laparoscopic cholecystectomy, likely attributed to erosion. On the patient's first presentation, she had acute pancreatitis with a CT demonstrating clips in the correct position. Three weeks later, the patient presented a second time with acute cholangitis and the repeat CT demonstrated the clips in the CBD. We hypothesize that the erosion of the bile duct is due to the pressure effects from either intra-abdominal organ movements or subtle clip movements, and eventually, persistent erosion leading to intra-ductal migration of the clips with the passage of the clips along the path of least resistance into the CBD, resulting in biliary obstruction. Management included standard treatment for biliary obstruction with intravenous broad-spectrum antibiotics and endoscopic retrograde cholangiopancreatography with excellent outcomes.

High-resolution impedance manometry characterizes the functional role of distal colonic motility in gas transit.

BACKGROUND: The colonic motor patterns associated with gas transit are poorly understood. This study describes the application of high-resolution impedance manometry (HRiM) in the human colon in vivo to characterize distal colonic motility and gas transit; (a) after a meal and (b) after intraluminal gas insufflation into the sigmoid colon. METHODS: HRiM recordings were performed in 19 healthy volunteers, with sensors positioned from the distal descending colon to the proximal rectum. Protocol 1 (n = 10) compared pressure and impedance prior to and after a meal. Protocol 2 (n = 9) compared pressure and impedance before and after gas insufflation into the sigmoid colon (60 mL total volume). KEY RESULTS: Both the meal and gas insufflation resulted in an increase in the prevalence of the 2-8/minute "cyclic motor pattern" (meal: (t(9) = -6.42, P<0.001); gas insufflation (t(8) = -3.13, P = 0.01)), and an increase in the number of antegrade and retrograde propagating impedance events (meal: Z = -2.80, P = 0.005; gas insufflation Z = -2.67, P = 0.008). Propagating impedance events temporally preceded antegrade and retrograde propagating contractions, representing a column of luminal gas being displaced ahead of a propagating contraction. Three participants reported an urge to pass flatus and/or flatus during the studies. CONCLUSIONS AND INFERENCES: Initiation of the 2-8/minute cyclic motor pattern in the distal colon occurs both following a meal and/or as a localized sensorimotor response to gas. The near-absence of a flatal urge and the temporal association between propagating contractions and gas transit supports the hypothesis that the 2-8/minute cyclic motor pattern acts as a physiological "brake" modulating rectal filling.

Health smart cards: differing perceptions of emergency department patients and staff.

An analytical, cross-sectional survey of 270 emergency department patients and 92 staff undertaken in three tertiary referral hospital emergency departments was completed to compare the perceptions of patients and staff regarding the use of health smart cards containing patient medical records. The study recorded data on a range of health smart card issues including awareness, privacy, confidentiality, security, advantages and disadvantages, and willingness to use. A significantly higher proportion of staff had heard of the card. The perceived disadvantages reported by patients and staff were, overall, significantly different, with the staff reporting more disadvantages. A significantly higher proportion of patients believed that they should choose what information is on the card and who should have access to the information. Patients were more conservative regarding what information should be included, but staff were more conservative regarding who should have access to the information. Significantly fewer staff believed that patients could reliably handle the cards. Overall, however, the cards were considered acceptable and useful, and their introduction would be supported.

Effect of electrode separation on high-resolution impedance manometry catheters for ex vivo animal experiments.

BACKGROUND: High-resolution impedance manometry (HRIM) catheters are used for esophageal reflux and bolus transit studies. Usually, these catheters have electrodes spaced at 20 mm intervals that are used for measuring electrical impedance between the consecutive electrodes and pressure sensors with 10 mm separation. Electrical impedance is a distributed measurement between the electrodes, unlike the point measurement of pressure sensors. Thus, the electrode separations affect the overall spatiotemporal resolution of the measurement. METHODS: A 3D model of the gastrointestinal tract, in which bolus shape and size can be modified, was used to simulate the admittance signal response of an intraluminal impedance catheter with 10 and 20 mm electrode separation to study the distributed sensitivity in the lumen to gain insight on the impedance measurement. In addition, experiments on sections of rabbit proximal colon were conducted with two catheters with electrode separations of 10 and 20 mm to compare the experimental data with the simulated data. KEY RESULTS: Reducing electrode spacing from 20 to 10 mm increased sensitivity to diameter change by a factor of ten. Admittance and diameter correlated strongly during a myogenic contraction with a Pearson's Correlation Coefficient of 0.86 for the custom catheter, in comparison with 0.56 for the commercial HRIM catheter. CONCLUSIONS: Ten millimeter electrode separation has a better spatiotemporal resolution, and unlike 20 mm electrode separation is able to identify myogenic contractions. Based on the numerical and experimental data, closer electrode separation should be considered for improved spatial resolution.

Handheld mobile telephone use among Melbourne drivers.

OBJECTIVE: To evaluate change in handheld mobile telephone (mobile) use among motor vehicle drivers between 2002 and 2006. DESIGN AND SETTING: Observational study of motor vehicle drivers at three times (10:00-11:00; 14:00-15:00; 17:00-18:00) on three consecutive Tuesdays in October 2006 at 12 highway sites in metropolitan Melbourne. MAIN OUTCOME MEASURES: Rates of handheld mobile use overall and by the sex and age of drivers, highway site (major metropolitan road, central business district, freeway exit ramp) and time of day. RESULTS: In 2002, 315 of 17 023, and in 2006, 331 of 20 207 drivers were observed using handheld mobiles. This represented a non-significant rate decrease from 18.5 to 16.3 users/1000 drivers (rate difference, 2.1 users/1000 drivers; 95% CI,- 0.6 to 4.8; P = 0.07). Unlike 2002, the rate of handheld mobile use among men in 2006 was significantly higher than for women (rate difference, 3.7 mobiles/1000 drivers; 95% CI, 0.1-7.3; P = 0.03). In both 2002 and 2006, mobile use was most common in the central business district. In 2002, there was significantly more mobile use in the evening, while in 2006, the evening rate was significantly lower than the morning rate (rate difference, 4.3; 95% CI, - 0.1 to 8.7; P = 0.03) and slightly lower than the afternoon rate (rate difference, 3.0; 95% CI, - 1.1 to 7.1; P = 0.08). The effect of age remained unchanged between 2002 and 2006, with older drivers using mobiles least (P < 0.001). CONCLUSION: The number of drivers at risk from handheld mobile phone use remains almost unchanged. However, a slight reduction in the rate of use overall and variations in use among driver subgroups are apparent. Policing and public awareness campaigns need to further address this preventable risk of injury.