RESUMEN
The level and qualitative spectrum of spontaneous chromosomal aberrations (CA) were comparatively analyzed in the lymphocytes of 655 children and adolescents from the Kemerovo Region. The presented sample was divided into 3 groups according to the type of an inhabited locality: 1) small miner's towns; 2) large industrial towns; and 3) rural localities. The maximum frequency of CA (3.77 +/- 0.22%) was noted in a group of dwellers in the miner's towns; its minimum frequency (2.68 +/- 0.17%) among the rural inhabitants. The significant clastogenic effects (including the markers of radiation exposure) were detected in the miner's towns located in the southern part of the region, which represented mountain and submountain areas. At the same time, in the northern and western parts of the Kemerovo Region, the average frequencies of CA in children and adolescents did not exceed the control background values. Thus, the residence in the inhabited localities specializing in mining is not a factor of absolute toxicogenetic risk.
Asunto(s)
Aberraciones Cromosómicas/estadística & datos numéricos , Minas de Carbón , Enfermedades Ambientales/genética , Contaminación Ambiental/efectos adversos , Adolescente , Niño , Preescolar , Enfermedades Ambientales/epidemiología , Femenino , Humanos , Masculino , Población Rural , Siberia/epidemiología , Población UrbanaRESUMEN
The authors studied frequencies of chromosomal aberration (CA) and sister chromatid exchanges (SCE) in workers of coal-tar chemical plant (34 individuals). The studies revealed significant increase of CA frequency (7.97 +/- 0.63%), when compared with reference groups 3.37 +/- 0.39% and 3.64 +/- 0.37%.
Asunto(s)
Industria Química , Aberraciones Cromosómicas/epidemiología , Enfermedades Profesionales/epidemiología , Adulto , Áreas de Influencia de Salud , Aberraciones Cromosómicas/diagnóstico , Aberraciones Cromosómicas/genética , Trastornos de los Cromosomas , Humanos , Masculino , Persona de Mediana Edad , Enfermedades Profesionales/diagnóstico , Federación de Rusia/epidemiología , Intercambio de Cromátides Hermanas/genéticaRESUMEN
The authors studied frequencies of chromosomal aberrations (CA) in 48 ore mining and processing workers exposed to occupational hazards complex. Finding is significantly increased frequency of CA, when compared to that in reference groups. Level of structural CA in the main group appeared not to depend on age, sex and bad habits (smoking). The study revealed indirect dependence between cytogenetic disorders frequency and length of service.