Association between sex of the individual with untreated cleft lip and social judgement made by lay persons: A cross-sectional study.

OBJECTIVE: To assess whether there is an association between an individual's sex and social judgements made by lay persons regarding untreated cleft lip. MATERIALS AND METHODS: Lay individuals over 18 years old were recruited through an application to respond online to two questionnaires: a sociodemographic survey and the Brazilian Version of Lay Persons' Social Judgements about Cleft-lip Scale (B-LSojCleft-S). B-LSojCleft-S comprises 14 items evaluating social judgements made by laypersons concerning different types of untreated cleft lips in teenagers. The 14 items are linked to 8 images featuring untreated cleft lips and 1 image without a cleft (control). Higher scores represented more favourable social judgements. Independent samples t-test, paired, and multiple linear regression were conducted (P < 0.05). The study assessed judgements of untreated cleft lips in male and female adolescents using the B-LSojCleft-S. RESULTS: The mean age of the 217 participants was 37.78 ± 12.39 years, predominantly women (72.7%), married (47.7%), with a monthly income below three minimum wages (35.6%) in the majority of cases. Significantly higher social judgement scores were observed in the control group (no cleft) compared to any type of cleft (P < 0.001), with similar scores obtained for the same types of clefts with female or male images (P > 0.05). The participant's sex is associated with social judgement scores (F [1, 214] = 6.318, P = 0.013; adjusted R2 = 0.024), with females making more favourable judgements than males (P < 0.05). CONCLUSIONS: Individuals with cleft lips receive more negative social judgement scores, regardless of their own sex. Women make better social judgements than men.

Angiogenesis and osteogenesis at incorporation process of onlay bone graft.

PURPOSE: The roles of angiogenesis and osteogenesis in autologous and allogenic bone grafts and the use of platelet-rich plasma (PRP) as a modifier were investigated. MATERIALS AND METHODS: Forty rabbit mandibles received onlay grafts of fresh autologous and frozen allogeneic bone. PRP was added on the right side. After intervals of 3, 7, 14, 28, and 56 days, the animals were euthanized. Hematoxylin and eosin staining was used to measure the quantity and area of osteoblasts. Sections stained with toluidine blue showed newly formed bone area. In sections with Weigert-van Gieson staining, the number of vessels and their lumens was quantified. The quantity and area of cellular arrangements expressing CD31 and the area of vessels were obtained. RESULTS: Quantities of osteoblasts and their areas, newly formed matrices, and vessels and their lumen areas were obtained and identified by immunomarking with CD31. In general, values for these were higher in rabbits with allogeneic bone grafts and on the sides where PRP had been added. There was a variable significance between categories and days. It was confirmed that osteogenesis was intensified when angiogenesis was consolidated. CONCLUSIONS: Angiogenesis was important for greater osteoblast differentiation and bone matrix synthesis, ensuring consolidation of onlay grafts with the receptor bed. Allogeneic grafts and PRP intensified these processes.

Application of botulinum toxin type A in gummy smile: case report / Aplicação da toxina botulínica tipo A em sorriso gengival: relato de caso

ABSTRACT Gummy smile is one of the major complaints of patients, due to its influence on the self-esteem. It is known that it has a multifactorial cause and can be present in the excessive vertical growth of the maxilla, excessive labial contraction, short upper lip and extrusion of the anterior teeth. The use of the botulinum toxin can be associated with additional treatments or be applied individually, according to the need of each patient. The goal of this research study was to present a clinical case using botulinum toxin type A as an alternative therapy to correct the gummy smile. A 22-year-old patient, presenting vertical maxillary growth, reporting aesthetic discomfort while smiling, chose for an alternative treatment therapy with the application of botulinum toxin to correct the accentuated gingival display. The results show that the toxin is a satisfactory treatment option and its indication is considered a fast, effective, easy and safe treatment method, being a more conservative approach compared to surgical procedures.

RESUMO O sorriso gengival, é uma das grandes queixas dos pacientes, devido a sua influência na auto estima do mesmo. Sua causa é multifatorial, podendo estar presente no excesso de crescimento vertical da maxila, contração labial excessiva, lábio superior curto e extrusão dos dentes anteriores. A aplicação da toxina botulínica pode ser associada a outros tratamentos ou isoladamente, de acordo com a necessidade de cada paciente. O objetivo desse trabalho foi apresentar um caso clinico utilizando a toxina botulínica tipo A como uma alternativa terapêutica para a correção do sorriso gengival. Paciente, 22 anos, apresentando crescimento vertical da maxila, relatando desconforto estético ao sorrir, optou pela alternativa terapêutica, com a aplicação da toxina botulínica para correção da exposição gengival acentuada. Os resultados encontrados mostram que a toxina é um tratamento satisfatório e sua indicação é considerada um tratamento rápido, eficaz, fácil e seguro. Um método mais conservador quando comparado aos procedimentos cirúrgicos.

Pattern of osteogenesis during onlay bone graft healing.

OBJECTIVE: The aim of this paper was to analyze how healing occurs between onlay bone graft and the mandible cortex. STUDY DESIGN: Autologous and allogeneic corticocancellous bones, harvested from the ilium wing, were grafted at each mandible side of 40 rabbits. One side received platelet-rich plasma (PRP). Killings occurred at 3, 7, 14, 28, and 56 days. Tissues were stained by hematoxylin-eosin and toluidine blue. New bone area was measured at different regions of sections stained with toluidine blue. Wilcoxon test was used to analyze differences among regions and Bonferroni test to analyze the influence of PRP, graft nature, and days. RESULTS: Osteogenesis was higher at the lateral region (P < .05). PRP tended to improve bone neoformation, which was higher at the allogeneic graft. Statistical significance among the different categories of variables-grafts, use of PRP, and days of observation-did not have a linear behavior. A linear behavior of statistical tests was not detected. Bone new formation increased until the 14th day (P < .05). CONCLUSIONS: Onlay grafts heal due to osteogenesis which occurs at the lateral region and between the cortex and host mandible. Allogeneic grafts and PRP tend to improve bone formation.

Adaptação de pino/núcleos metálicos fundidos modelados com diferentes resinas acrílicas / Adjustment of cast metal post/cores modeled with diferente acylic resins

Aim: Evaluate the performance of four commercially available chemically-activated acrylic resins (CAARs) by measuring the level of displacement of the cores following casting. Materials and Methods: Two devices were constructed to model the cores based on a natural tooth. Forty post/cores were modeled, 10 in each of the following CAARs: Duralay (Reliance Dental, Illinois, USA), Pattern Resin (GC, Tokyo, Japan), Dencrilay (Dencril, Sao Paulo, Brazil), and Jet (Clássico, Sao Paulo, Brazil). Two casting rings were included, each of which contained 5 post/cores for each of the four CAARs tested, a total of 20 per ring. Following casting, the specimens were only sandblasted and separated from the feeding channels. The post/cores were placed in device 1 and, with the aid of an optical microscope, were attached to a digital camera. Images were then taken of the adjustment between the core and the remaining tooth on the labial surface. The images were processed using the Image Tool for Windows, version 3.0, measuring three fixed points in each specimen. Data were statistically analyzed using the ANOVA and Tukey test. Results: The 40 post/cores were divided into eight groups according to resin brand and casting, obtaining the following results for mean and standard deviation (in mm): Dencrilay 0.192 CI (± 0.08), CII 0.058 (± 0.03); Duralay CI 0.097 (± 0.03), CII 0.131 (± 0.06); Pattern CI 0.07 (± 0.03), CII 0.10 (± 0.05); and Jet CI 0.06 (± 0.02), CII 0.382 (± 0.17). Statistically significant differences could be identified when comparing the Dencrilay CI and the Jet CII with the remaining groups, which all proved to be unfavorable. Conclusion: The quality of cast metal post/core adjustment is not associated with the use of a specific acrylic resin.

Prevalência da doença periodontal em diabéticos controlados / Prevalence of periodontal disease in controlled diabetics

Objetivo: o presente estudo teve como objetivo pesquisar, utilizando os parâmetros clínicos periodontais, a prevalência da doença periodontal em indivíduos portadores de diabetes mellitus tipo 2 metabolicamente controlados. Material e métodos: o controle metabólico foi avaliado utilizando como parâmetro o ensaio da hemoglobina glicosilada, cuja média apresentada pela amostra foi de 5,79%. Esta foi constituída por 105 indivíduos com média de idade de 55,8 anos, apresentando diabetes tipo 2, assistidos pelo programa Hiperdia, da Prefeitura de Camaçari, no período entre 2007 e 2009. A periodontite foi caracterizada por, no mínimo, uma bolsa de 4 mm associada à perda de inserção maior ou igual a 4 mm e sangramento gengival. Já para determinação da gengivite, foi considerada a presença de vermelhidão gengival e o sangramento a sondagem em 25% dos sítios. Resultados: a porcentagem de faces coradas foi de 61,15% e a de sangramento a sondagem foi de 62%. Em relação à medida de profundidade de sondagem dos sítios sondados, 89,92% foram enquadradas no subgrupo associado à saúde; 9,19% à profundidade de sondagem moderada; e 0,89% à severa. Sobre a perda de inserção, 76,65% não apresentaram perda de inserção ou perda leve; 14,28% apresentaram perda de inserção moderada e 9,02% apresentaram perda grave; 84 pacientes (80%) apresentaram periodontite crônica; 12 pacientes (11,4%) foram enquadrados nos critérios de diagnóstico para gengivite e nove (8,6%) registraram saúde periodontal. Conclusão: através dos parâmetros clínicos periodontais utilizados neste estudo, foi possível observar uma prevalência de 80% de periodontite e 11,4% de gengivite entre os indivíduos diabéticos controlados metabolicamente.

Importância do uso da tomografia computadorizada no diagnóstico e planejamento endodôntico: relato de caso clínico / The importance of the use of computed tomography in diagnosis and in endodontic planning: a case report

Objetivo: relatar um caso clínico de reintervenção endodôntica em paciente submetido a cirurgia ortognática, com uso de tomografia computadorizada para auxílio no diagnóstico e plano de tratamento. Métodos: a paciente foi encaminhada para avaliação endodôntica dos dentes anteriores com história pregressa de cirurgia ortognática em maxila e presença de placas de fixação interna rígida na região próxima aos ápices dentários. Resultados: a avaliação tridimensional da região demonstrou a lesão periapical do incisivo central esquerdo. A reintervenção endodôntica resultou na remissão dos sintomas e regressão da rarefação óssea periapical. Conclusão: a utilização da tomografia computadorizada foi imprescindível para a resolução do caso relatado, o que ficou comprovado com a neoformação óssea

Osteoimunologia aplicada às reconstruções maxilofaciais: [revisão] / Osteoimmunology applied to maxillofacial reconstruction: [review]

Esta revisão de literatura teve por objetivo discutir os aspectos atuais da osteoimunologia aplicada às reconstruções maxilofaciais. As reabilitações maxilares por implantes podem demandar enxertia óssea para prévia adequação do rebordo à colocação do implante. Os enxertos ósseos alógenos têm sido introduzidos nesse protocolo para evitar cirurgia numa segunda área. A criopreservação figura como um método importante para diminuir a antigenicidade do tecido, mas outras técnicas podem ser exemplificadas como a esterilização por radiação gama ou óxido de etileno. A imunologia participa do processo de incorporação ou de rejeição dos enxertos ósseos incrementando sua absorção. Diversas moléculas, como as interleucinas, o ligante do receptor ativador do fator nuclear-κβ (RANKL), o fator nuclear de células T ativadas (NFAT), o fator estimulador de colônias de macrófagos (M-CSF), o fator de células B jovens (EBF-2) e a osteoprotegerina estabelecem a relação entre as células imunológicas e o metabolismo do osso enxertado. As evidências obtidas da literatura permitem inferir que o osso alógeno congelado é um bom material para aposição dos maxilares por não induzir rejeição imunológica.

This literature review aimed to discuss some current aspects related to osteoimmunology applied to maxillofacial reconstruction. Maxillary rehabilitation with implants may demand bone grafting before implant placement in the alveolar ridge. Allografts have been introduced to prevent surgery in a secondary area. Cryopreservation is an important method to decrease tissue antigenicity, but other techniques can also be used such as sterilization by gamma radiation or ethylene oxide. Immunology may participate in the incorporation or rejection process of bone grafts by increasing bone resorption. Several molecules, such as interleukins, receptor activators of nuclear factor κβ ligand RANKL, nuclear factor of activated T cells (NFAT), macrophage-colony stimulating factor (M-CSF), early B cell factor (EBF-2), and osteopontegrin establish the relation between immunological cells and bone graft metabolism. Evidences from the literature suggest that frozen allogenic bone may be a good material for jaw onlay grafts since they do not induce immunological rejection.

Osteoimunologia aplicada às reconstruções maxilofaciais / Osteoimmunology applied to maxillofacial reconstruction

Esta revisão de literatura teve por objetivo discutir os aspectos atuais da osteoimunologia aplicada às reconstruções maxilofaciais. As reabilitações maxilares por implantes podem demandar enxertia óssea para prévia adequação do rebordo à colocação do implante. Os enxertos ósseos alógenos têm sido introduzidos nesse protocolo para evitar cirurgia numa segunda área. A criopreservação figura como um método importante para diminuir a antigenicidade do tecido, mas outras técnicas podem ser exemplificadas como a esterilização por radiação gama ou óxido de etileno. A imunologia participa do processo de incorporação ou de rejeição dos enxertos ósseos incrementando sua absorção. Diversas moléculas, como as interleucinas, o ligante do receptor ativador do fator nuclear-κβ (RANKL), o fator nuclear de células T ativadas (NFAT), o fator estimulador de colônias de macrófagos (M-CSF), o fator de células B jovens (EBF-2) e a osteoprotegerina estabelecem a relação entre as células imunológicas e o metabolismo do osso enxertado. As evidências obtidas da literatura permitem inferir que o osso alógeno congelado é um bom material para aposição dos maxilares por não induzir rejeição imunológica.

This literature review aimed to discuss some current aspects related to osteoimmunology applied to maxillofacial reconstruction. Maxillary rehabilitation with implants may demand bone grafting before implant placement in the alveolar ridge. Allografts have been introduced to prevent surgery in a secondary area. Cryopreservation is an important method to decrease tissue antigenicity, but other techniques can also be used such as sterilization by gamma radiation or ethylene oxide. Immunology may participate in the incorporation or rejection process of bone grafts by increasing bone resorption. Several molecules, such as interleukins, receptor activators of nuclear factor κβ ligand RANKL, nuclear factor of activated T cells (NFAT), macrophage-colony stimulating factor (M-CSF), early B cell factor (EBF-2), and osteopontegrin establish the relation between immunological cells and bone graft metabolism. Evidences from the literature suggest that frozen allogenic bone may be a good material for jaw onlay grafts since they do not induce immunological rejection.