Detalles de la búsqueda
1.
A Symbolic Regression Model for the Prediction of Drug Binding to Human Liver Microsomes.
Mol Pharm
; 20(5): 2436-2442, 2023 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37000176
2.
Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development.
Pharm Res
; 39(7): 1321-1341, 2022 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-35411506
3.
Mechanistic understanding of brain drug disposition to optimize the selection of potential neurotherapeutics in drug discovery.
Pharm Res
; 31(8): 2203-19, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24623476
4.
Optimising wound care in a child with an infected gastrostomy exit site.
Br J Nurs
; 22(22): 1275-9, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24335863
5.
Development and implementation of an enterprise-wide predictive model for early absorption, distribution, metabolism and excretion properties.
Future Med Chem
; 13(19): 1639-1654, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34528444
6.
The fluorescent two-hybrid assay to screen for protein-protein interaction inhibitors in live cells: targeting the interaction of p53 with Mdm2 and Mdm4.
J Biomol Screen
; 19(4): 516-25, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24476585
7.
Development and validation of a higher-throughput equilibrium dialysis assay for plasma protein binding.
J Lab Autom
; 16(1): 56-67, 2011 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21609686
8.
Prediction of human oral plasma concentration-time profiles using preclinical data: comparative evaluation of prediction approaches in early pharmaceutical discovery.
Clin Pharmacokinet
; 50(8): 505-17, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21740074
9.
Ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry for robust, high-throughput quantitative analysis of an automated metabolic stability assay, with simultaneous determination of metabolic data.
Rapid Commun Mass Spectrom
; 20(5): 851-7, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16470510
10.
The search for novel TRPV1-antagonists: from carboxamides to benzimidazoles and indazolones.
Bioorg Med Chem Lett
; 16(11): 2872-6, 2006 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16563760
11.
An evaluation of a four-channel multiplexed electrospray tandem mass spectrometry for higher throughput quantitative analysis.
Anal Chem
; 74(8): 1896-902, 2002 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-11985324
12.
Determination of drug concentrations in plasma by a highly automated, generic and flexible protein precipitation and liquid chromatography/tandem mass spectrometry method applicable to the drug discovery environment.
Rapid Commun Mass Spectrom
; 16(11): 1065-71, 2002.
Artículo
en Inglés
| MEDLINE | ID: mdl-11992509
13.
Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma.
Drug Metab Dispos
; 30(8): 937-43, 2002 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-12124313
Resultados
1 -
13
de 13
1
Próxima >
>>