RESUMEN
BACKGROUND: A reliable early marker is required for diagnosis of cobalamin deficiency. We calculated an appropriate holotranscobalamin (HoloTC) cut-off point for identifying cobalamin deficiency using an immunoenzymatic assay. METHODS: Determination of the cut-off threshold and correlation between HoloTC and the other diagnostic parameters routinely used for vitamin B(12) deficiency [total vitamin B(12) (tB(12)), folate, homocysteine] were measured in 250 routine blood specimens from 107 men (mean age 59.0+/-18.8 years) and 143 women (mean age 54.2+/-23.1 years). The inclusion criterion was serum tB(12) concentration Asunto(s)
Análisis Químico de la Sangre/instrumentación
, Transcobalaminas/metabolismo
, Deficiencia de Vitamina B 12/sangre
, Vitamina B 12/sangre
, Anciano
, Biomarcadores/sangre
, Biomarcadores/metabolismo
, Femenino
, Ácido Fólico/sangre
, Ácido Fólico/metabolismo
, Homocisteína/sangre
, Homocisteína/metabolismo
, Humanos
, Técnicas para Inmunoenzimas
, Masculino
, Persona de Mediana Edad
, Sensibilidad y Especificidad
, Vitamina B 12/metabolismo
, Deficiencia de Vitamina B 12/diagnóstico
, Deficiencia de Vitamina B 12/metabolismo
, Complejo Vitamínico B/sangre
, Complejo Vitamínico B/metabolismo