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1.
Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy.
J Cell Mol Med
; 25(20): 9634-9646, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34486218
2.
Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner.
Int J Mol Sci
; 22(4)2021 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33579026
3.
Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A.
Pharmacol Res
; 151: 104558, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31759088
4.
Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain.
J Neurosci
; 36(49): 12485-12497, 2016 12 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27927963
5.
Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson's disease in young and adult mouse.
Exp Brain Res
; 235(7): 2189-2202, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28439627
6.
Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice.
Proc Natl Acad Sci U S A
; 111(32): 11876-81, 2014 Aug 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25071172
7.
Prolyl oligopeptidase enhances α-synuclein dimerization via direct protein-protein interaction.
J Biol Chem
; 290(8): 5117-5126, 2015 Feb 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-25555914
8.
Prolyl oligopeptidase inhibition reduces PolyQ aggregation and improves cell viability in cellular model of Huntington's disease.
J Cell Mol Med
; 23(12): 8511-8515, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31565846
9.
The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse.
Neurobiol Dis
; 68: 1-15, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24746855
10.
5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein-Protein Interaction-Derived Functions.
J Med Chem
; 67(7): 5421-5436, 2024 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-38546708
11.
Thymosin ß4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis.
Kidney Int
; 84(6): 1166-75, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23739235
12.
Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon.
Neurobiol Aging
; 129: 62-71, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37271045
13.
Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson's Disease.
J Med Chem
; 66(11): 7475-7496, 2023 06 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37248563
14.
A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy.
Sci Transl Med
; 15(691): eabq2915, 2023 04 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37043557
15.
Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model.
Neuropharmacology
; 218: 109213, 2022 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35964686
16.
Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration.
Biomed Pharmacother
; 146: 112501, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-34891119
17.
Sequential expression, activity and nuclear localization of prolyl oligopeptidase protein in the developing rat brain.
Dev Neurosci
; 33(1): 38-47, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21160163
18.
Deletion or inhibition of prolyl oligopeptidase blocks lithium-induced phosphorylation of GSK3b and Akt by activation of protein phosphatase 2A.
Basic Clin Pharmacol Toxicol
; 129(4): 287-296, 2021 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-34196102
19.
Multiplexed analysis of amino acids in mice brain microdialysis samples using isobaric labeling and liquid chromatography-high resolution tandem mass spectrometry.
J Chromatogr A
; 1656: 462537, 2021 Oct 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-34537659
20.
2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors.
ACS Med Chem Lett
; 12(10): 1578-1584, 2021 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-34671446