Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 96
Filtrar
Más filtros

Bases de datos
País/Región como asunto
Tipo del documento
Intervalo de año de publicación
1.
Cereb Cortex ; 23(12): 2932-43, 2013 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-22977063

RESUMEN

Neurologic impairment is a major complication of complex congenital heart disease (CHD). A growing body of evidence suggests that neurologic dysfunction may be present in a significant proportion of this high-risk population in the early newborn period prior to surgical interventions. We recently provided the first evidence that brain growth impairment in fetuses with complex CHD has its origins in utero. Here, we extend these observations by characterizing global and regional brain development in fetuses with hypoplastic left heart syndrome (HLHS), one of the most severe forms of CHD. Using advanced magnetic resonance imaging techniques, we compared in vivo brain growth in 18 fetuses with HLHS and 30 control fetuses from 25.4-37.0 weeks of gestation. Our findings demonstrate a progressive third trimester fall-off in cortical gray and white matter volumes (P < 0.001), and subcortical gray matter (P < 0.05) in fetuses with HLHS. Significant delays in cortical gyrification were also evident in HLHS fetuses (P < 0.001). In the HLHS fetus, local cortical folding delays were detected as early as 25 weeks in the frontal, parietal, calcarine, temporal, and collateral regions and appear to precede volumetric brain growth disturbances, which may be an early marker of elevated risk for third trimester brain growth failure.


Asunto(s)
Corteza Cerebral/anomalías , Feto/anomalías , Síndrome del Corazón Izquierdo Hipoplásico/patología , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Embarazo
2.
J Exp Med ; 164(6): 1958-72, 1986 Dec 01.
Artículo en Inglés | MEDLINE | ID: mdl-3491174

RESUMEN

Kawasaki syndrome (KS) is an acute febrile illness of early childhood characterized by diffuse vasculitis and marked immune activation. The present study was undertaken to determine whether the acute phase of KS is associated with circulating cytotoxic antibodies directed to target antigens induced on vascular endothelium by the monokines, IL-1, or tumor necrosis factor (TNF). Sera from 20 patients with acute KS, 11 patients in the convalescent phase of KS, and 17 age-matched controls were assessed for complement-dependent cytotoxic activity against 111In-labeled human endothelial cells (HEC), dermal fibroblasts, and vascular smooth muscle cells. Sera from patients with acute KS but not the other subject groups caused significant (p less than 0.01) complement-mediated killing of IL-1- or TNF-stimulated HEC. None of the sera tested had cytotoxicity against control HEC cultures or the other target cell types, with or without IL-1 or TNF pretreatment. Expression of the IL-1- or TNF-inducible target antigens on endothelial cells was rapid and transient, peaking at 4 h and disappearing after 24 h despite continued incubation with monokine. In contrast, we have previously shown that IFN-gamma requires 72 h to render HEC susceptible to lysis with acute KS sera. Serum adsorption studies demonstrated that IL-1- and TNF-inducible endothelial target antigens are distinct from IFN-gamma-inducible antigens. These observations suggest that mediator secretion by activated monocyte/macrophages could be a predisposing factor to the development of vascular injury in acute KS. Although our present observations have been restricted to KS, the development of cytotoxic antibodies directed to monokine-inducible endothelial cell antigens may also be found in other vasculitides accompanied by immune activation.


Asunto(s)
Anticuerpos/inmunología , Glicoproteínas/farmacología , Interleucina-1/farmacología , Síndrome Mucocutáneo Linfonodular/inmunología , Venas/efectos de los fármacos , Antígenos de Superficie/inmunología , Línea Celular , Supervivencia Celular/efectos de los fármacos , Preescolar , Endotelio/efectos de los fármacos , Femenino , Humanos , Lactante , Masculino , Factor de Necrosis Tumoral alfa , Venas/citología
3.
AJNR Am J Neuroradiol ; 41(8): 1525-1531, 2020 08.
Artículo en Inglés | MEDLINE | ID: mdl-32646947

RESUMEN

BACKGROUND AND PURPOSE: Brain MRI of newborns with congenital heart disease show signs of immaturity relative to healthy controls. Our aim was to determine whether the semiquantitative fetal total maturation score can detect abnormalities in brain maturation in fetuses with congenital heart disease in the second and third trimesters. MATERIALS AND METHODS: We analyzed data from a prospective study of fetuses with and without congenital heart disease who underwent fetal MR imaging at 25-35 weeks' gestation. Two independent neuroradiologists blinded to the clinical data reviewed and scored all images using the fetal total maturation score. Interrater reliability was evaluated by the intraclass correlation coefficient using the individual reader scores, which were also used to calculate an average score for each subject. Comparisons of the average and individual reader scores between affected and control fetuses and relationships with clinical variables were evaluated using multivariable linear regression. RESULTS: Data from 69 subjects (48 cardiac, 21 controls) were included. High concordance was observed between readers with an intraclass correlation coefficient of 0.98 (95% CI, 0.97-0.99). The affected group had significantly lower fetal total maturation scores than the control group (ß-estimate, -0.9 [95% CI, -1.5 to -0.4], P = .002), adjusting for gestational age and sex. Averaged fetal total maturation, germinal matrix, myelination, and superior temporal sulcus scores were significantly delayed in fetuses with congenital heart disease versus controls (P < .05 for each). The fetal total maturation score was not significantly associated with any cardiac, anatomic, or physiologic variables. CONCLUSIONS: The fetal total maturation score is sensitive to differences in brain maturation between fetuses with isolated congenital heart disease and healthy controls.


Asunto(s)
Encéfalo/anomalías , Encéfalo/embriología , Feto/diagnóstico por imagen , Feto/embriología , Cardiopatías Congénitas/complicaciones , Adulto , Encéfalo/diagnóstico por imagen , Femenino , Humanos , Interpretación de Imagen Asistida por Computador/métodos , Recién Nacido , Imagen por Resonancia Magnética/métodos , Masculino , Embarazo , Diagnóstico Prenatal/métodos , Estudios Prospectivos , Reproducibilidad de los Resultados
4.
J Clin Invest ; 79(2): 468-72, 1987 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-2433307

RESUMEN

The effect of intravenous gammaglobulin (IVGG) on the immunoregulatory abnormalities found during acute Kawasaki syndrome (KS) was studied in a randomized trial of IVGG plus aspirin (ASA) versus ASA alone. Before therapy, patients in each treatment group had increased numbers of circulating HLA-DR-bearing Leu 3+ helper T cells, a deficiency of Leu 2+ suppressor/cytotoxic T cells, and increased levels of spontaneous IgG and IgM synthesis by peripheral blood mononuclear cells. There were no significant differences (P greater than 0.1) between immunologic parameters measured on day 1 and day 4 in the ASA-treated group. In contrast, patients treated with ASA plus IVGG had by day 4 a highly significant decrease in HLA-Dr+ Leu 3+ helper T cells (P less than 0.001), an increase in Leu 2+ suppressor/cytotoxic T cells (P less than 0.01), and a decrease in spontaneous IgG (P less than 0.01) and IgM synthesis (P less than 0.001). These changes were associated with a reduction in the secretion of T cell-derived B cell helper factors (P less than 0.001). These findings indicate that treatment with IVGG suppresses the marked T and B cell activation found in patients with acute KS.


Asunto(s)
Aspirina/uso terapéutico , Activación de Linfocitos , Síndrome Mucocutáneo Linfonodular/inmunología , gammaglobulinas/uso terapéutico , Anticuerpos Monoclonales , Preescolar , Ensayos Clínicos como Asunto , Femenino , Antígenos HLA-DR/análisis , Humanos , Infusiones Intravenosas , Masculino , Síndrome Mucocutáneo Linfonodular/terapia , Distribución Aleatoria , Valores de Referencia , Linfocitos T/clasificación , Linfocitos T/inmunología , gammaglobulinas/administración & dosificación
5.
Circulation ; 100(5): 526-32, 1999 Aug 03.
Artículo en Inglés | MEDLINE | ID: mdl-10430767

RESUMEN

BACKGROUND: It is not known whether developmental and neurological outcomes in the preschool period differ depending on whether the predominant vital organ support strategy used in infant heart surgery was total circulatory arrest (CA) or low-flow cardiopulmonary bypass. METHODS AND RESULTS: Infants with D-transposition of the great arteries who underwent an arterial-switch operation were randomly assigned to a support method consisting predominantly of CA or low-flow cardiopulmonary bypass. Developmental and neurological status were evaluated blindly at 4 years of age in 158 of 163 eligible children (97%). Neither IQ scores nor overall neurological status were significantly associated with either treatment group or duration of CA. The CA group scored lower on tests of motor function (gross motor, P=0.01; fine motor, P=0.03) and had more severe speech abnormalities (oromotor apraxia, P=0.007). Seizures in the perioperative period, detected either clinically or by continuous electroencephalographic monitoring, were associated with lower mean IQ scores (12.6 and 7.7 points, respectively) and increased risk of neurological abnormalities (odds ratios, 8.4 and 5.6, respectively). The performance of the full cohort was below expectations in several domains, including IQ, expressive language, visual-motor integration, motor function, and oromotor control. CONCLUSIONS: Use of CA to support vital organs during open heart surgery in infancy is associated, at the age of 4 years, with worse motor coordination and planning but not with lower IQ or with worse overall neurological status.


Asunto(s)
Procedimientos Quirúrgicos Cardíacos/métodos , Puente Cardiopulmonar/efectos adversos , Discapacidades del Desarrollo/etiología , Hipotermia Inducida/efectos adversos , Inteligencia , Destreza Motora , Enfermedades del Sistema Nervioso/etiología , Transposición de los Grandes Vasos/cirugía , Procedimientos Quirúrgicos Cardíacos/efectos adversos , Preescolar , Discapacidades del Desarrollo/fisiopatología , Discapacidades del Desarrollo/psicología , Femenino , Audición , Humanos , Masculino , Enfermedades del Sistema Nervioso/fisiopatología , Enfermedades del Sistema Nervioso/psicología , Examen Neurológico , Estudios Prospectivos , Riesgo , Habla , Resultado del Tratamiento
6.
Circulation ; 104(12 Suppl 1): I138-42, 2001 Sep 18.
Artículo en Inglés | MEDLINE | ID: mdl-11568045

RESUMEN

BACKGROUND: To study the long-term impact on general health status of D-transposition of the great arteries (D-TGA) after the arterial switch operation (ASO) during infancy, we asked parents to complete the Child Health Questionnaire, Parent Form-50 when their children were 8 years old. METHODS AND RESULTS: Of 160 eligible patients, questionnaires were completed for 155 subjects (96%). Median age at surgery was 6 days (range 1 to 67 days), and median age at completion of the Child Health Questionnaire was 8.1 years (7.6 to 10.0 years). Subsequent to questionnaire completion, children underwent psychometric testing. Mean Physical Health Summary and Psychosocial Summary scores were 54.0+/-6.1 and 49.7+/-9.9, respectively, which were similar to those of normal subjects. Compared with the normative sample, parents of D-TGA patients reported more problems with attention, learning, and speech, as well as greater frequency of developmental delay (P<0.001 for each). Worse Psychosocial Summary scores were significantly associated with lower full-scale IQ (P=0.001) and lower achievement in reading (P=0.005) and math (P=0.007). Worse Physical Health Summary scores were associated with longer hospital stay after the ASO (P=0.02). General health status scores were not significantly related to presence of ventricular septal defect, age at surgery, perfusion variables during the ASO, sex, or history of cardiac reoperation. CONCLUSIONS: At age 8 years, children with D-TGA after ASO have an overall physical and psychosocial health status similar to that of the general population. Lower IQ and academic achievement are associated with worse psychosocial health status, whereas longer hospital course after initial surgery is associated with worse physical health status.


Asunto(s)
Daño Encefálico Crónico/diagnóstico , Procedimientos Quirúrgicos Cardiovasculares/estadística & datos numéricos , Indicadores de Salud , Transposición de los Grandes Vasos/cirugía , Daño Encefálico Crónico/etiología , Procedimientos Quirúrgicos Cardiovasculares/efectos adversos , Niño , Estudios de Cohortes , Estudios de Seguimiento , Humanos , Lactante , Recién Nacido , Pruebas Neuropsicológicas , Calidad de Vida , Factores de Riesgo , Encuestas y Cuestionarios , Tiempo , Resultado del Tratamiento , Escalas de Wechsler
7.
Circulation ; 102(8): 883-9, 2000 Aug 22.
Artículo en Inglés | MEDLINE | ID: mdl-10952957

RESUMEN

BACKGROUND: Patients with a single ventricle have multiple risk factors for central nervous system injury, both before and after the Fontan procedure. METHODS AND RESULTS: A geographically selected cohort was invited to undergo standardized testing, including age-appropriate measures of intelligence quotient (IQ) and achievement tests. Historical information was obtained by chart review and patient questionnaires. Of the 222 eligible patients, 133 (59.9%) participated. Median age at testing was 11.1 years (range, 3. 7 to 41.0 years), 6.0 years (range, 1.6 to 19.6 years) after surgery. Mean full-scale IQ was 95.7+/-17.4 (P<0.006 versus normal); 10 patients (7.8%) had full-scale IQ scores <70 (P=0.001). After adjustment for socioeconomic status, lower IQ was associated with the use of circulatory arrest before the Fontan operation (P=0.002), the anatomic diagnoses of hypoplastic left heart syndrome (P<0.001) and "other complex" (P=0.05), and prior placement of a pulmonary artery band (P=0.04). Mean composite achievement score was 91.6+/-15. 4 (P<0.001 versus normal); 14 patients (10.8%) scored <70 (P<0.001). After adjustment for socioeconomic status, independent risk factors for low achievement scores included the diagnoses of hypoplastic left heart syndrome (P=0.004) and "other complex" (P=0.003) or prior use of circulatory arrest (P=0.03), as well as a reoperation with cardiopulmonary bypass within 30 days of the Fontan (P=0.01). CONCLUSIONS: Most individual patients palliated with the Fontan procedure in the 1970s and 1980s have cognitive outcome and academic function within the normal range, but the performance of the cohort is lower than that of the general population.


Asunto(s)
Trastornos del Conocimiento/etiología , Procedimiento de Fontan/efectos adversos , Cardiopatías Congénitas/complicaciones , Adolescente , Adulto , Puente Cardiopulmonar/efectos adversos , Niño , Preescolar , Evaluación Educacional/métodos , Estudios de Seguimiento , Cardiopatías Congénitas/cirugía , Ventrículos Cardíacos/anomalías , Ventrículos Cardíacos/cirugía , Humanos , Pruebas de Inteligencia , Discapacidades para el Aprendizaje/etiología , Análisis Multivariante , Encuestas y Cuestionarios , Resultado del Tratamiento
8.
Pediatrics ; 69(6): 747-50, 1982 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-7079039

RESUMEN

The incidence of divorce or legal separation was studied in 438 families of children born with heart disease who entered the New England Regional Infant Cardiac Program between 1968 and 1973. The parents were interviewed when the children were 5 1/2 years old. The rate of divorce in 438 families of children with critical congenital heart disease was not significantly different from the rate in two comparison groups: (1) 25 families of children whose cardiac defect was spontaneously cured, and (2) 26 families of children catheterized in infancy for suspected cardiac defect but who were found to be free of heart disease. Rates of divorce or legal separation for the three groups were: critical congenital heart disease, 12.1%, spontaneously cured, 4.2% free of heart disease, 11.5% these rates were not significantly different. The average national divorce rate was 20.3% for the same period.


Asunto(s)
Divorcio , Cardiopatías Congénitas/psicología , Padres/psicología , Adulto , Preescolar , Femenino , Estudios de Seguimiento , Humanos , Masculino , New England , Factores Socioeconómicos
9.
Pediatrics ; 95(3): 323-30, 1995 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-7862467

RESUMEN

OBJECTIVE: To examine the impact of hospital caseload on in-hospital mortality for pediatric congenital heart surgery. DESIGN: Population-based, retrospective cohort study. SETTING: Acute care hospitals in California and Massachusetts. PATIENTS: Children undergoing surgery for congenital heart disease, identified by the presence of procedure codes indicating surgical repair of a congenital heart defect in computerized statewide hospital discharge abstract databases. Cases were grouped into four categories based on the complexity of the procedure. MAIN OUTCOME MEASURES: Adjusted odds ratios (OR) for in-hospital death were estimated using generalized estimating equations that account for the intra-institutional correlation among patients. RESULTS: A total of 2833 cases at 37 centers were identified. Compared with centers performing > 300 cases per year, after controlling for patient characteristics, centers performing < 10 cases per year had an OR for in-hospital death of 7.7 (95% confidence interval (CI) [1.6-37.8]); 10 to 100 cases, OR = 2.9 (95% CI [1.6-5.3]); 101 to 300 cases, OR = 3.0 (95% CI [1.8-4.9]). Independent risk factors for mortality included procedure complexity category (P < .0001), use of cardiopulmonary bypass (P < .0001), young age at surgery (P = .001), and transfer from another acute care hospital (P < .0001). Few differences were found by hospital caseload in length of stay or total hospital charges. CONCLUSIONS: For children with a congenital heart defect who underwent surgery in California in 1988 or Massachusetts in 1989, the risk of dying in-hospital was much lower if the surgery was performed at an institution performing > 300 cases annually. This study was limited by the absence of clinical detail in discharge abstract databases. If these findings are corroborated by other studies, health care delivery strategies that direct children requiring surgical correction of congenital heart defects to high-volume centers may substantially reduce overall mortality.


Asunto(s)
Procedimientos Quirúrgicos Cardíacos/mortalidad , Servicio de Cardiología en Hospital/estadística & datos numéricos , Cardiopatías Congénitas/cirugía , Mortalidad Hospitalaria , Carga de Trabajo/estadística & datos numéricos , California/epidemiología , Procedimientos Quirúrgicos Cardíacos/estadística & datos numéricos , Servicio de Cardiología en Hospital/normas , Niño , Preescolar , Estudios de Cohortes , Femenino , Precios de Hospital , Humanos , Tiempo de Internación , Masculino , Massachusetts/epidemiología , Oportunidad Relativa , Estudios Retrospectivos
10.
Pediatrics ; 92(1): 78-82, 1993 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-8516088

RESUMEN

OBJECTIVE: To determine the efficacy and adverse effects of niacin treatment of hypercholesterolemia in children. DESIGN: Retrospective review. SETTING: Two university hospital referral clinics. PATIENTS: All children who received single-drug niacin treatment for severe hypercholesterolemia between 1980 and 1991. RESULTS: Twenty-one children, aged 4 to 14 years, were treated with niacin, 500 to 2250 mg daily. Pretreatment total serum cholesterol value (mean +/- SD) was 7.84 +/- 1.14 mmol/L (303 +/- 44 mg/dL), and low-density lipoprotein cholesterol value was 6.28 +/- 1.16 mmol/L (243 +/- 45 mg/dL). Niacin treatment in daily doses > 1000 mg reduced total cholesterol by 23% and low-density lipoprotein cholesterol by 30% (P < .001) but had no effect on high-density lipoprotein cholesterol and triglycerides. As in adults, reversible adverse effects were common, occurring in 16 (76%) of the 21 children. Six children (29%) had reversible dose-related elevations of serum aminotransferase levels. Niacin therapy was discontinued in 8 children (38%) because of flushing, abdominal pain, vomiting, headache, or elevated serum aminotransferase levels. CONCLUSIONS: This study suggests that although niacin treatment in children is efficacious, adverse effects are common. Until further study demonstrates long-term safety, niacin treatment should be reserved for the closely-supervised treatment of severe hypercholesterolemia by a lipid specialist.


Asunto(s)
Hipercolesterolemia/tratamiento farmacológico , Niacina/uso terapéutico , Adolescente , Niño , Preescolar , LDL-Colesterol/sangre , Femenino , Humanos , Hipercolesterolemia/sangre , Masculino , Niacina/efectos adversos , Estudios Retrospectivos , Resultado del Tratamiento
11.
Am J Cardiol ; 83(12): 1649-53, 1999 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-10392870

RESUMEN

We sought to determine the impact of prenatal diagnosis on the perioperative outcome of newborns with hypoplastic left heart syndrome (HLHS) and transposition of the great arteries (TGA). All neonates with HLHS or TGA encountered at Children's Hospital, Boston, Massachusetts, from January 1988 to May 1996 were identified and outcomes documented. Birth characteristics, preoperative, operative, and postoperative variables of term newborns with a prenatal diagnosis of HLHS or TGA who underwent a Norwood operation (n = 27) or arterial switch operation (n = 14), respectively, were compared with newborns with a postnatal diagnosis of HLHS (n = 47) or TGA (n = 28) who had undergone surgery. Of 217 neonates with HLHS and 422 with TGA, 39 and 16, respectively, had a prenatal diagnosis. The preoperative mortality among neonates aggressively managed did not differ between the prenatal and postnatal diagnosis groups for either HLHS or TGA (p >0.05). Neonates with a prenatal diagnosis who underwent surgery had objective indicators of lower severity of illness preoperatively, including a higher lowest recorded pH (p = 0.03), lower maximum blood urea nitrogen (p = 0.002), and creatinine (p = 0.03) among newborns with HLHS, and a tendency toward higher minimum of partial pressure of arterial oxygen in the TGA group (p = 0.06). Prenatal diagnosis was not associated with an improved postoperative course or operative mortality (p <0.05) within a diagnostic group. Thus, a prenatal diagnosis improves the preoperative condition of neonates with HLHS and TGA, but may not significantly improve preoperative mortality or early postoperative outcome among neonates managed at a tertiary care center.


Asunto(s)
Síndrome del Corazón Izquierdo Hipoplásico/diagnóstico , Diagnóstico Prenatal , Transposición de los Grandes Vasos/diagnóstico , Humanos , Síndrome del Corazón Izquierdo Hipoplásico/mortalidad , Síndrome del Corazón Izquierdo Hipoplásico/cirugía , Recién Nacido , Atención Perinatal , Pronóstico , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Factores de Tiempo , Transposición de los Grandes Vasos/mortalidad , Transposición de los Grandes Vasos/cirugía
12.
Am J Cardiol ; 81(9): 1116-20, 1998 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-9605052

RESUMEN

To construct a predictive instrument for developing coronary artery abnormalities in patients with acute Kawasaki disease treated with aspirin and intravenous gamma globulin within the first 10 days of illness, data available from a multicenter database of patients with acute Kawasaki disease were analyzed. A development data set (n = 212) was used to construct a sequential risk classification instrument based on easily measured baseline laboratory test results and temperature. The instrument was then validated in 3 test data sets (n = 192, 264, and 92, respectively). Risk factors used in the sequential classification instrument included baseline neutrophil and band counts, hemoglobin concentration, platelet count, and temperature on the day after infusion of intravenous gamma globulin. In the development data set, the instrument classified 123 of 212 patients (58%) as low risk; none developed coronary artery abnormalities. Among 89 patients classified as high risk, 3 of 36 female (8.3%) and 9 of 53 male patients (17.0%) developed coronary artery abnormalities. The instrument performed similarly in the 3 test data sets; no patient in any data set classified as low risk developed coronary artery abnormalities. This simple instrument allows the clinician to identify within 1 day of treatment low-risk children in whom extensive and frequent cardiac testing may be unnecessary, as well as high-risk children who require closer monitoring and may be candidates for additional therapies.


Asunto(s)
Aneurisma Coronario/etiología , Síndrome Mucocutáneo Linfonodular/complicaciones , Aneurisma Coronario/prevención & control , Femenino , Humanos , Inmunoglobulinas Intravenosas/uso terapéutico , Masculino , Síndrome Mucocutáneo Linfonodular/tratamiento farmacológico , Valor Predictivo de las Pruebas , Pronóstico , Ensayos Clínicos Controlados Aleatorios como Asunto , Medición de Riesgo
13.
J Thorac Cardiovasc Surg ; 121(2): 374-83, 2001 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-11174744

RESUMEN

OBJECTIVES: In a randomized single-center trial, we compared developmental and neurologic outcomes at 1 and 2 to 4 years of age in children who underwent reparative cardiac operations at less than 9 months of age after use of the alpha-stat versus pH-stat strategy during deep hypothermic cardiopulmonary bypass. METHODS: Among 168 children eligible for follow-up, 1-year developmental evaluations were carried out on 111, neurologic evaluations on 110, and electroencephalographic evaluations on 102. Parents of 122 children completed questionnaires on behavior and development when children were 2 to 4 years of age. RESULTS: The Psychomotor Development Index scores of the alpha-stat and pH-stat groups did not differ significantly (P =.97). For Mental Development Index scores, the treatment group effect differed according to diagnosis (P =.007). In the D -transposition of the great arteries (n = 59) and tetralogy of Fallot (n = 36) subgroups, the pH-stat group had slightly higher Mental Development Index scores than the alpha-stat group, although these differences were not statistically significant. In the ventricular septal defect subgroup (n = 16), the alpha-stat group had significantly higher scores. Psychomotor Development Index and Mental Development Index scores were significantly higher in the group with D -transposition of the great arteries than in the other 2 groups (P =.03 and P =.01, respectively). Across all diagnoses, Mental Development Index scores were significantly higher than Psychomotor Development Index scores (P <.001). Treatment group assignment was not significantly associated with abnormalities on neurologic examination (P =.70) or electroencephalographic examination (P =.77) at 1 year or with parents' ratings of children's development (P =.99) or behavior (P =.27) at age 2 to 4 years. CONCLUSIONS: Use of alpha-stat versus pH-stat acid-base management strategy during reparative infant cardiac operations with deep hypothermic cardiopulmonary bypass was not consistently related to either improved or impaired early neurodevelopmental outcomes.


Asunto(s)
Dióxido de Carbono/sangre , Desarrollo Infantil , Hipotermia Inducida/métodos , Temperatura Corporal , Conducta Infantil , Preescolar , Discapacidades del Desarrollo/sangre , Discapacidades del Desarrollo/diagnóstico , Discapacidades del Desarrollo/etiología , Electroencefalografía , Femenino , Estudios de Seguimiento , Defectos del Tabique Interventricular/sangre , Defectos del Tabique Interventricular/cirugía , Humanos , Concentración de Iones de Hidrógeno , Hipotermia Inducida/efectos adversos , Lactante , Masculino , Examen Neurológico , Estudios Prospectivos , Tetralogía de Fallot/sangre , Tetralogía de Fallot/cirugía , Transposición de los Grandes Vasos/sangre , Transposición de los Grandes Vasos/cirugía
14.
J Thorac Cardiovasc Surg ; 114(3): 392-403; discussion 404-5, 1997 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-9305191

RESUMEN

OBJECTIVES: The purpose of this study was to describe the functional outcome of a large number of patients after modifications of the Fontan operation and to investigate perioperative risk factors that might influence late functional state. METHODS: A comprehensive cross-sectional review of the first 500 patients undergoing a Fontan operation at our institution was undertaken. Those surviving with an intact Fontan circulation were reviewed by questionnaire to assess functional status and medication history. Medical records, chest roentgenograms, echocardiograms, cardiac catheterizations, and laboratory investigations were also reviewed to assess postoperative status. RESULTS: Three hundred sixty-three long-term survivors with an intact Fontan circulation were identified during cross-sectional follow-up. Median age at operation was 5.0 years (range 0.4 to 31 years), and median follow-up was 5.4 years (range 1.7 to 20 years). Most patients (91.1%) were in New York Heart Association class I or II. In a multivariate model, poor (class III or IV) functional state was associated with longer duration of follow-up (p < 0.001), a prior atrial septectomy (p = 0.03), and a prior main pulmonary artery-ascending aorta anastomosis (p = 0.05). CONCLUSIONS: A poor functional outcome is uncommon after the Fontan operation but becomes more frequent with increasing duration of follow-up.


Asunto(s)
Procedimiento de Fontan , Cardiopatías Congénitas/cirugía , Complicaciones Posoperatorias/epidemiología , Adolescente , Adulto , Niño , Preescolar , Estudios Transversales , Femenino , Estudios de Seguimiento , Procedimiento de Fontan/estadística & datos numéricos , Estado de Salud , Cardiopatías Congénitas/epidemiología , Cardiopatías Congénitas/fisiopatología , Humanos , Tablas de Vida , Modelos Logísticos , Masculino , Morbilidad , Reoperación , Factores de Riesgo , Factores de Tiempo , Resultado del Tratamiento
15.
J Thorac Cardiovasc Surg ; 110(4 Pt 1): 924-33, 1995 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-7475158

RESUMEN

Cardiopulmonary bypass is a planned support technique that results in a period of myocardial ischemia and reperfusion. In addition, it is associated with an inflammatory response likely involving endothelial cell activation. In previous studies, we showed that E-selectin and intercellular adhesion molecule-1 (ICAM-1) messenger ribonucleic acid (mRNA) are increased in human myocardium after cardiopulmonary bypass. We have now examined the expression of P-selectin mRNA by ribonuclease protection in paired atrial biopsy specimens from 12 patients before and after cardiopulmonary bypass. By means of immunocytochemistry, we have also examined the endothelial cell surface expression of P-selectin protein, as well as that of E-selectin and ICAM-1 in three additional patients. Patient ages ranged from 1 day to 8.5 years (median 12 months), and cardiopulmonary bypass times ranged from 46 to 196 minutes (median 144 minutes). By ribonuclease protection, there was marked variability in the expression of P-selectin in biopsy specimens before bypass. However, when compared with prebypass levels, P-selectin mRNA decreased modestly in 10 of 12 patients after bypass (median decrease 1.5-fold, p = 0.016). As seen with immunocytochemistry, P-selectin protein was distributed diffusely through the vascular bed on large vessels and small vessels before bypass but was virtually absent on capillaries in specimens taken after bypass. E-selectin, which was absent in prebypass biopsy specimens, was induced in one of the three specimens after bypass, but no change in ICAM-1 protein expression above baseline was noted. We also find that cultured human endothelial cells treated with tumor necrosis factor-alpha in doses which induce ICAM-1 mRNA simultaneously decrease their expression of P-selectin mRNA as compared with untreated cells. These observations suggest that endothelial P-selectin is transcriptionally downregulated after cardiopulmonary bypass at times when E-selectin and ICAM-1 are induced. Furthermore, we find that E-selectin and ICAM-1 are expressed at times and at sites where P-selectin is absent. Although it is possible that P-selectin may have been induced and lost at early times before reperfusion, these data suggest that endothelial P-selectin plays a limited role in the inflammatory response that ensues after cardiopulmonary bypass.


Asunto(s)
Puente Cardiopulmonar , Miocardio/metabolismo , Selectina-P/metabolismo , Adolescente , Células Cultivadas , Niño , Preescolar , Selectina E/metabolismo , Endotelio Vascular/metabolismo , Cardiopatías Congénitas/cirugía , Humanos , Inmunohistoquímica , Lactante , Recién Nacido , Molécula 1 de Adhesión Intercelular/metabolismo , Músculo Esquelético/metabolismo , Selectina-P/genética , ARN Mensajero/metabolismo , Piel/metabolismo , Factor de Necrosis Tumoral alfa/farmacología
16.
J Thorac Cardiovasc Surg ; 107(5): 1183-92, 1994 May.
Artículo en Inglés | MEDLINE | ID: mdl-7513775

RESUMEN

Leukocyte adhesion to vascular endothelium is an early step in inflammatory damage to tissues. To investigate the expression of endothelial adhesion molecules in the inflammatory response associated with cardiopulmonary bypass, we measured messenger ribonucleic acid (mRNA) encoding the adhesion molecules E-selectin and intercellular adhesion molecule-1 in intraoperative samples of cardiac tissue and skeletal muscle from infants undergoing cardiopulmonary bypass. Atrial tissue samples were obtained before and after bypass from 11 children and paired samples of rectus abdominis muscle from 15. mRNA was analyzed by ribonuclease protection with the use of nonmuscle actin as an internal control. Atrial E-selectin mRNA levels increased from before to after bypass (median increase 3.5-fold, p = 0.0002) in each of nine patients tested, and atrial intercellular adhesion molecule-1 mRNA increased in seven of nine patients (median, 2.1-fold, p = 0.025). In skeletal muscle, E-selectin mRNA increased in 11 of 12 patients (median 4.3-fold, p = 0.0018), and intercellular adhesion molecule-1 mRNA levels increased in 13 of 13 patients (median 3.2-fold, p = 0.013). E-selectin and intercellular adhesion molecule-1 induction in skeletal muscle occurred with or without circulatory arrest. We conclude that adhesion molecule mRNA induction occurs in cardiac and noncardiac tissue during cardiopulmonary bypass in man.


Asunto(s)
Puente Cardiopulmonar , Moléculas de Adhesión Celular/biosíntesis , Miocardio/metabolismo , Recto del Abdomen/metabolismo , Moléculas de Adhesión Celular/genética , Selectina E , Atrios Cardíacos , Cardiopatías Congénitas/cirugía , Humanos , Lactante , Molécula 1 de Adhesión Intercelular , Daño por Reperfusión Miocárdica/metabolismo , ARN Mensajero/genética , Daño por Reperfusión/metabolismo
17.
J Thorac Cardiovasc Surg ; 106(2): 362-8, 1993 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-8341077

RESUMEN

To examine whether pH management during core cooling is a risk factor for adverse developmental outcome, we studied 16 children with transposition of the great arteries and intact ventricular septum who underwent a Senning procedure in infancy (median age 32 days, range 2 to 154 days) between 1983 and 1988. Information was collected retrospectively on many aspects of perfusion, including lowest carbon dioxide tension during core cooling, duration of core cooling, and duration of circulatory arrest. The pH strategy changed from pH-stat to alpha-stat in 1985, resulting in a wide range of pH values and carbon dioxide tension (34 to 76 mm Hg) during the study period. All children had rapid core cooling to a rectal temperature of 19.8 degrees +/- 2.7 degrees C (mean +/- standard deviation) and a tympanic temperature of 16.6 degrees +/- 3.0 degrees C. Development was assessed at median age 48.0 (11 to 79) months with the Bayley Scales (n = 4, children younger than 30 months) or the McCarthy Scales (n = 12, children older than 30 months). The mean core-cooling duration was 14.5 +/- 6.2 minutes, circulatory arrest time was 43.4 +/- 6.6 minutes, and total bypass plus circulatory arrest time was 89.7 +/- 12.7 minutes. Lower carbon dioxide tension (alpha-stat) before onset of circulatory arrest was associated with worse developmental outcome (r = 0.71, p = 0.002). This relationship remained highly significant when we controlled for sociodemographic and intraoperative variables. including core-cooling time, circulatory arrest time, and total elapsed time. Duration of circulatory arrest was not associated with developmental outcome. We conclude that when relatively rapid core cooling is used to achieve hypothermia before circulatory arrest in young infants, a more alkaline pH strategy such as alpha-stat may result in less effective cerebral protection.


Asunto(s)
Dióxido de Carbono/sangre , Paro Cardíaco Inducido/métodos , Hipotermia Inducida , Desarrollo Infantil , Preescolar , Femenino , Defectos del Tabique Interventricular/cirugía , Humanos , Concentración de Iones de Hidrógeno , Lactante , Recién Nacido , Pruebas de Inteligencia , Masculino , Estudios Retrospectivos , Factores de Riesgo , Clase Social , Transposición de los Grandes Vasos/cirugía
18.
J Thorac Cardiovasc Surg ; 114(3): 376-91, 1997 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-9305190

RESUMEN

OBJECTIVES: The purpose of this study was to review a large, evolving, single-center experience with the Fontan operation and to determine risk factors influencing early and late outcome. METHODS: The first 500 patients undergoing modifications of the Fontan operation at our institution were identified. Perioperative variables were recorded and a cross-sectional review of survivors was undertaken. RESULTS: The incidence of early failure decreased from 27.1% in the first quartile of the experience to 7.5% in the last quartile. In a multivariate model, the following variables were associated with an increased probability of early failure: a mean preoperative pulmonary artery pressure of 19 mm Hg or more (p < 0.001), younger age at operation (p = 0.001), heterotaxy syndrome (p = 0.03), a right-sided tricuspid valve as the only systemic atrioventricular valve (p = 0.001), pulmonary artery distortion (p = 0.04), an atriopulmonary connection originating at the right atrial body or appendage (p = 0.001), the absence of a baffle fenestration (p = 0.002), and longer cardiopulmonary bypass time (p = 0.001). An increased probability of late failure was associated with the presence of a pacemaker before the Fontan operation (p < 0.001). A morphologically left ventricle with normally related great arteries or a single right ventricle (excluding heterotaxy syndrome and hypoplastic left heart syndrome) were associated with a decreased probability of late failure (p = 0.003). CONCLUSIONS: These analyses indicate that early failure has declined over the study period and that this decline is related in part to procedural modifications. A continuing late hazard phase is associated with few patient-related variables and does not appear related to procedural variables.


Asunto(s)
Procedimiento de Fontan , Cardiopatías Congénitas/cirugía , Complicaciones Posoperatorias/epidemiología , Niño , Preescolar , Estudios Transversales , Femenino , Estudios de Seguimiento , Procedimiento de Fontan/mortalidad , Procedimiento de Fontan/estadística & datos numéricos , Cardiopatías Congénitas/mortalidad , Humanos , Incidencia , Masculino , Modelos de Riesgos Proporcionales , Factores de Riesgo , Análisis de Supervivencia , Factores de Tiempo , Insuficiencia del Tratamiento
19.
J Thorac Cardiovasc Surg ; 114(6): 991-1000; discussion 1000-1, 1997 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-9434694

RESUMEN

OBJECTIVES: In a randomized, single-center trial, we compared perioperative outcomes in infants undergoing cardiac operations after use of the alpha-stat versus pH-stat strategy during deep hypothermic cardiopulmonary bypass. METHODS: Admission criteria included reparative cardiac surgery, age less than 9 months, birth weight 2.25 kg or more, and absence of associated congenital or acquired extracardiac disorders. RESULTS: Among the 182 infants in the study, diagnoses included D-transposition of the great arteries (n = 92), tetralogy of Fallot (n = 50), tetralogy of Fallot with pulmonary atresia (n = 6), ventricular septal defect (n = 20), truncus arteriosus (n = 8), complete atrioventricular canal (n = 4), and total anomalous pulmonary venous return (n = 2). Ninety patients were assigned to alpha-stat and 92 to pH-stat strategy. Early death occurred in four infants (2%), all in the alpha-stat group (p = 0.058). Postoperative electroencephalographic seizures occurred in five of 57 patients (9%) assigned to alpha-stat and one of 59 patients (2%) assigned to pH-stat strategy (p = 0.11). Clinical seizures occurred in four infants in the alpha-stat group (4%) and two infants in the pH-stat group (2%) (p = 0.44). First electroencephalographic activity returned sooner among infants randomized to pH-stat strategy (p = 0.03). Within the homogeneous D-transposition subgroup, those assigned to pH-stat tended to have a higher cardiac index despite a lower requirement for inotropic agents; less frequent postoperative acidosis (p = 0.02) and hypotension (p = 0.05); and shorter duration of mechanical ventilation (p = 0.01) and intensive care unit stay (p = 0.01). CONCLUSIONS: Use of the pH-stat strategy in infants undergoing deep hypothermic cardiopulmonary bypass was associated with lower postoperative morbidity, shorter recovery time to first electroencephalographic activity, and, in patients with D-transposition, shorter duration of intubation and intensive care unit stay. These data challenge the notion that alpha-stat management is a superior strategy for organ protection during reparative operations in infants using deep hypothermic cardiopulmonary bypass.


Asunto(s)
Equilibrio Ácido-Base , Procedimientos Quirúrgicos Cardíacos , Puente Cardiopulmonar , Hipotermia Inducida , Complicaciones Posoperatorias/prevención & control , Electroencefalografía , Hemodinámica/fisiología , Humanos , Concentración de Iones de Hidrógeno , Lactante , Recién Nacido , Cuidados Intraoperatorios/métodos , Estudios Prospectivos , Convulsiones/prevención & control
20.
Pediatr Infect Dis J ; 8(2): 116-8, 1989 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-2468129

RESUMEN

Kawasaki syndrome is a systemic vasculitis in which bilateral nonexudative conjunctivitis and bilateral anterior uveitis are common findings early in the course of the illness. Slit lamp examination is a useful clinical tool in differentiating patients with KS from patients with other diseases characterized by fever, rash and bilateral conjunctivitis. Referral to a pediatric ophthalmologist early in the course of the illness can help in the diagnosis of this disease.


Asunto(s)
Enfermedades de la Conjuntiva/diagnóstico , Síndrome Mucocutáneo Linfonodular/diagnóstico , Uveítis Anterior/diagnóstico , Diagnóstico Diferencial , Humanos , Inmunización Pasiva , Inyecciones Intravenosas , Síndrome Mucocutáneo Linfonodular/terapia , gammaglobulinas/administración & dosificación
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA