Detalles de la búsqueda
1.
Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy.
Annu Rev Pharmacol Toxicol
; 61: 225-245, 2021 01 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33035445
2.
Radiation in Combination with Immune Checkpoint Blockade and DNA Damage Response Inhibitors in Mice: Dosage Optimization in MC38 Syngeneic Tumors via Modelling and Simulation.
J Pharmacol Exp Ther
; 387(1): 44-54, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37348964
3.
Exploring the Boundaries for In Vitro-In Vivo Extrapolation: Use of Isolated Rat Hepatocytes in Co-culture and Impact of Albumin Binding Properties in the Prediction of Clearance of Various Drug Types.
Drug Metab Dispos
; 51(11): 1463-1473, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-37580106
4.
Evaluation of area under the concentration curve adjusted by the terminal-phase as a metric to reduce the impact of variability in bioequivalence testing.
Br J Clin Pharmacol
; 88(2): 619-627, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34272747
5.
Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats.
Mol Pharm
; 18(8): 2997-3009, 2021 08 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34283621
6.
Dose individualisation in oncology using chemotherapy-induced neutropenia: Example of docetaxel in non-small cell lung cancer patients.
Br J Clin Pharmacol
; 87(4): 2053-2063, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33075149
7.
Comprehensive Evaluation of the Utility of 20 Endogenous Molecules as Biomarkers of OATP1B Inhibition Compared with Rosuvastatin and Coproporphyrin I.
J Pharmacol Exp Ther
; 368(1): 125-135, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30314992
8.
Development and validation of a methotrexate adherence assay.
Ann Rheum Dis
; 78(9): 1192-1197, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31167761
9.
A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents.
Eur J Clin Pharmacol
; 75(9): 1227-1235, 2019 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-31172248
10.
A study of the dosage and duration for levobupivacaine infusion by the caudal-epidural route in infants aged 3-6 months.
Paediatr Anaesth
; 29(2): 161-168, 2019 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-30447167
11.
Capsaicin-evoked cough responses in asthmatic patients: Evidence for airway neuronal dysfunction.
J Allergy Clin Immunol
; 139(3): 771-779.e10, 2017 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-27444176
12.
Study design and population pharmacokinetic analysis of a phase II dose-ranging study of interleukin-1 receptor antagonist.
J Pharmacokinet Pharmacodyn
; 43(1): 1-12, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26476629
13.
Physiologically based pharmacokinetic model for 6-mercpatopurine: exploring the role of genetic polymorphism in TPMT enzyme activity.
Br J Clin Pharmacol
; 80(1): 86-100, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25614061
14.
A physiologically based pharmacokinetic model for clobazam and stiripentol in adults and children.
Pharm Res
; 32(1): 144-57, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25052507
15.
Model-based evaluation of the impact of formulation and food intake on the complex oral absorption of mavoglurant in healthy subjects.
Pharm Res
; 32(5): 1764-78, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25425054
16.
Application of a Bayesian approach to physiological modelling of mavoglurant population pharmacokinetics.
J Pharmacokinet Pharmacodyn
; 42(6): 639-57, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26231433
17.
Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 1: methotrexate.
J Pharmacokinet Pharmacodyn
; 41(2): 159-71, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24651961
18.
Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 2: 6-mercaptopurine and its interaction with methotrexate.
J Pharmacokinet Pharmacodyn
; 41(2): 173-85, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24651962
19.
Hierarchical cluster analysis and nonlinear mixed-effects modelling for candidate biomarker detection in preclinical models of cancer.
Eur J Pharm Sci
; 197: 106774, 2024 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38641123
20.
Covariates in population pharmacokinetic studies of critically ill adults receiving ß-lactam antimicrobials: a systematic review and narrative synthesis.
JAC Antimicrob Resist
; 6(1): dlae030, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38410250