1.
Cell Metab
; 36(6): 1169-1171, 2024 Jun 04.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38838638
RESUMEN
In this issue of Cell Metabolism, Fang et al.1 report a novel pH-sensitive cellular signaling mechanism involving the transcription factor SMAD5 that regulates the vesicular secretion of insulin from pancreatic ß cells in response to dietary challenges. Dysregulation of this pathway may contribute to metabolic disorders such as type 2 diabetes mellitus.