RESUMEN
BACKGROUND AND PURPOSE: Coronavirus disease 2019 (COVID-19) is associated with a small but clinically significant risk of stroke, the cause of which is frequently cryptogenic. In a large multinational cohort of consecutive COVID-19 patients with stroke, we evaluated clinical predictors of cryptogenic stroke, short-term functional outcomes and in-hospital mortality among patients according to stroke etiology. METHODS: We explored clinical characteristics and short-term outcomes of consecutively evaluated patients 18 years of age or older with acute ischemic stroke (AIS) and laboratory-confirmed COVID-19 from 31 hospitals in 4 countries (3/1/20-6/16/20). RESULTS: Of the 14.483 laboratory-confirmed patients with COVID-19, 156 (1.1%) were diagnosed with AIS. Sixty-one (39.4%) were female, 84 (67.2%) white, and 88 (61.5%) were between 60 and 79 years of age. The most frequently reported etiology of AIS was cryptogenic (55/129, 42.6%), which was associated with significantly higher white blood cell count, c-reactive protein, and D-dimer levels than non-cryptogenic AIS patients (p=0.05 for all comparisons). In a multivariable backward stepwise regression model estimating the odds of in-hospital mortality, cryptogenic stroke mechanism was associated with a fivefold greater odds in-hospital mortality than strokes due to any other mechanism (adjusted OR 5.16, 95%CI 1.41-18.87, p = 0.01). In that model, older age (aOR 2.05 per decade, 95%CI 1.35-3.11, p < 0.01) and higher baseline NIHSS (aOR 1.12, 95%CI 1.02-1.21, p = 0.01) were also independently predictive of mortality. CONCLUSIONS: Our findings suggest that cryptogenic stroke among COVID-19 patients carries a significant risk of early mortality.
Asunto(s)
COVID-19/complicaciones , Mortalidad Hospitalaria , Accidente Cerebrovascular Isquémico/virología , Sistema de Registros , Adulto , Anciano , Anciano de 80 o más Años , Isquemia Encefálica , COVID-19/sangre , COVID-19/diagnóstico por imagen , COVID-19/mortalidad , Estudios de Cohortes , Angiografía por Tomografía Computarizada , Egipto/epidemiología , Femenino , Productos de Degradación de Fibrina-Fibrinógeno/metabolismo , Humanos , Accidente Cerebrovascular Isquémico/sangre , Accidente Cerebrovascular Isquémico/diagnóstico por imagen , Accidente Cerebrovascular Isquémico/mortalidad , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Factores de Riesgo , SARS-CoV-2 , España/epidemiología , Accidente Cerebrovascular , Estados Unidos/epidemiologíaRESUMEN
Purpose: Intraoperative identification and excision of specific lymphadenopathies is not always easy; it is, therefore, important to have complementary techniques that help us in the identification of these structures intraoperatively. The aim of this study is to present preliminary results of the use of ROLL technique (radioguided occult lesion localisation) as a method of excisional biopsy in the head and neck territory. Material and methods: We present 10 cases of patients with difficult to localise lymphadenopathies in the head and neck territory that underwent the ROLL technique. The radiotracer was only injected in the nodes that we wanted to study; in this way, all of them were correctly identified and extracted without resecting those that had no signs of pathology avoiding removing healthy lymphatic tissue and reducing morbidity. Results: The ROLL technique is a useful technique, since in all of the patients, the previously marked adenopathy was accurately identified and excised; we reduced the intraoperative time and avoided the complications derived from more aggressive cervical exploratory surgeries.