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1.
Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates.
Drug Metab Dispos
; 47(10): 1206-1221, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31439574
2.
Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor.
J Pharmacol Exp Ther
; 365(2): 237-248, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29453199
3.
Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs.
Pharm Res
; 33(5): 1115-25, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26786016
4.
Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.
J Pharmacol Exp Ther
; 353(1): 213-33, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25665805
5.
Expression profiles of metabolic enzymes and drug transporters in the liver and along the intestine of beagle dogs.
Drug Metab Dispos
; 40(8): 1603-10, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22596220
6.
Mechanistic Population Pharmacokinetic Model of Oseltamivir and Oseltamivir Carboxylate Accounting for Physiological Changes to Predict Exposures in Neonates and Infants.
Clin Pharmacol Ther
; 108(1): 126-135, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31957010
7.
Importance of target-mediated drug disposition for small molecules.
Drug Discov Today
; 23(12): 2023-2030, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29928850
8.
Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches.
Clin Pharmacol Ther
; 104(5): 865-889, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30059145
9.
Characterising Drug Release from Immediate-Release Formulations of a Poorly Soluble Compound, Basmisanil, Through Absorption Modelling and Dissolution Testing.
AAPS J
; 19(3): 827-836, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28236228
10.
Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling.
AAPS J
; 19(2): 534-550, 2017 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-28050713
11.
Physiologically Based Absorption Modeling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Alectinib.
AAPS J
; 18(6): 1464-1474, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27450228
12.
Dissolution media simulating the proximal canine gastrointestinal tract in the fasted state.
Eur J Pharm Biopharm
; 84(3): 633-41, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23434923
13.
Impact of target interactions on small-molecule drug disposition: an overlooked area.
Nat Rev Drug Discov
; 17(4): 299, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29472637
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