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J Neuroimmunol ; 291: 110-4, 2016 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-26857504

RESUMEN

Environmental factors are implicated in the development of Parkinson's disease (PD). We have investigated on the role of molecular mimicry between HSV1 and α-synuclein that could foster the progression of PD. The antibody response against homologous peptides in PD patients and healthy controls was evaluated, showing that these antibodies are highly prevalent among PD patients to healthy controls. The competitive assay demonstrated cross-reactivity between HSV1 and human α-synuclein peptides. The results may suggest the hypothesis of the involvement of HSV1 in stimulating the immune cells against the neurons of the substantia nigra as a consequence of the cross reactivity.


Asunto(s)
Proteína Vmw65 de Virus del Herpes Simple/metabolismo , Enfermedad de Parkinson/complicaciones , alfa-Sinucleína/metabolismo , Anciano , Estudios de Casos y Controles , Reacciones Cruzadas , Ensayo de Inmunoadsorción Enzimática , Femenino , Humanos , Masculino , Persona de Mediana Edad , Imitación Molecular , Péptidos/metabolismo , Curva ROC , Sustancia Negra/metabolismo , Sustancia Negra/patología
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