Asunto(s)
Agammaglobulinemia/etiología , Inmunidad Celular , Inmunodeficiencia Combinada Grave/etiología , Adenosina Desaminasa/deficiencia , Adenosina Desaminasa/genética , Adenosina Desaminasa/inmunología , Agammaglobulinemia/genética , Agammaglobulinemia/inmunología , Preescolar , Consanguinidad , Femenino , Heterocigoto , Historia del Siglo XX , Humanos , Lactante , Inmunodeficiencia Combinada Grave/genética , Inmunodeficiencia Combinada Grave/inmunologíaRESUMEN
OBJECTIVES: The objectives of this study were to determine the presenting symptoms, healthcare utilization, and lost time from work and day care associated with acute rotavirus gastroenteritis. METHODS: During the winter to spring seasons of 2002-2003 or 2003-2004, children <36 months of age presenting with acute gastroenteritis to urban and suburban pediatric outpatient practices affiliated with 5 academic centers across the United States were enrolled in similarly designed studies. The case definition required >or=3 watery or looser-than-normal stools and/or forceful vomiting within a 24-hour period beginning Asunto(s)
Gastroenteritis/epidemiología
, Gastroenteritis/virología
, Infecciones por Rotavirus/epidemiología
, Enfermedad Aguda
, Factores de Edad
, Atención Ambulatoria
, Niño
, Preescolar
, Estudios de Cohortes
, Brotes de Enfermedades
, Femenino
, Gastroenteritis/diagnóstico
, Gastroenteritis/terapia
, Servicios de Salud/estadística & datos numéricos
, Humanos
, Lactante
, Recién Nacido
, Masculino
, Pediatría
, Estudios Prospectivos
, Infecciones por Rotavirus/diagnóstico
, Infecciones por Rotavirus/terapia
, Estados Unidos/epidemiología
RESUMEN
To evaluate the safety and immunogenicity of palivizumab, 55 children who received palivizumab in the IMpact-RSV trial received 5 monthly doses of 15 mg/kg palivizumab (Synagis) during the subsequent year. The single child with an antipalivizumab titer of >1/40 had no associated serious adverse events and had expected serum palivizumab trough concentrations. Second year palivizumab prophylaxis was safe and well-tolerated.