RESUMEN
Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his chest. He was diagnosed with MM based on histology, extensive immunohistochemical analyses, and an elevated serum CA-125 level. Cytogenetics and comparative genomic hybridization (CGH) analysis of his tumor identified a single extra copy number of chromosome 11 with few other changes noted.
Asunto(s)
Mesotelioma/diagnóstico , Mesotelioma/genética , Neoplasias Peritoneales/diagnóstico , Neoplasias Peritoneales/genética , Antígeno Ca-125/sangre , Niño , Cromosomas Humanos Par 11 , Hibridación Genómica Comparativa , Humanos , Inmunohistoquímica , Masculino , Mesotelioma/patología , Mesotelioma/terapia , Neoplasias Peritoneales/patología , Neoplasias Peritoneales/terapiaRESUMEN
The authors report a case of a rare facial myxoma arising from the maxillary sinus in a 20-month-old child. The diagnosis was confirmed by a biopsy, and the patient underwent a partial maxillectomy to achieve a total resection of the mass due to the locally aggressive nature of the lesion. Myxomas should be differentiated from malignant sarcomas, in particular embryonal rhabdomyosarcoma, which can arise from the same location and require multimodality therapy consisting of surgery, irradiation, and chemotherapy.
Asunto(s)
Neoplasias del Seno Maxilar/cirugía , Mixoma/cirugía , Biopsia , Diagnóstico Diferencial , Femenino , Humanos , Lactante , Neoplasias del Seno Maxilar/diagnóstico , Neoplasias del Seno Maxilar/patología , Mixoma/diagnóstico , Mixoma/patologíaRESUMEN
A 17-year-old patient with sickle cell-beta thalassemia undergoing treatment with home iron chelation therapy inadvertently received ten times the recommended dose of intravenous deferoxamine. Acute renal failure (ARF) developed within hours. Immediate treatment with high-efficiency hemodialysis resulted in the prompt return of renal function after only one hemodialysis session. No long-term nephrotoxic effects of the deferoxamine overdose developed after more than 1 year of follow-up. Children with sickle cell disease who are on intravenous deferoxamine and their parents should be cautioned about the possibility of ARF with overdose due to malfunction of the pump and/or inadequate monitoring during treatment. ARF, should it occur in such children, appears to respond well to treatment with high-efficiency hemodialysis.
Asunto(s)
Lesión Renal Aguda/inducido químicamente , Deferoxamina/envenenamiento , Quelantes del Hierro/envenenamiento , Lesión Renal Aguda/terapia , Adolescente , Anemia de Células Falciformes/tratamiento farmacológico , Sobredosis de Droga , Humanos , Masculino , Diálisis Renal , Talasemia beta/tratamiento farmacológicoRESUMEN
The case of a patient with an undifferentiated metastatic cardiac sarcoma is presented. A thallium-201 tumor study was performed to evaluate lung nodules. Thallium-201 chloride was injected intravenously and whole body images, as well as single photon emission computer tomography (SPECT) imaging of the chest, were obtained and reconstructed. They were displayed in three planes and then reconstructed again in cardiac planes. Multiple unsuspected metastases were found in the lower extremities. Viable tumor was demonstrated in both cerebral hemispheres. The lung nodules were not clearly identified. However, cold areas in the myocardium were detected corresponding to the findings on magnetic resonance imaging (MRI). In retrospect, at least one abdominal metastasis was identified. Whole body tumor imaging plays an important role in finding unsuspected primaries and in staging neoplasms to optimize patient care.