Analysis of continuous infusion functional PET (fPET) in the human brain.

Functional positron emission tomography (fPET) is a neuroimaging method involving continuous infusion of 18-F-fluorodeoxyglucose (FDG) radiotracer during the course of a PET examination. Compared with the conventional bolus administration of FDG in a static PET scan, which provides an average glucose uptake into the brain over an extended period of up to 30 â€‹min, fPET offers a significantly higher temporal resolution to study the dynamics of glucose uptake. Several earlier studies have applied fPET to investigate brain FDG uptake and study its relationship with functional magnetic resonance imaging (fMRI). However, due to the unique characteristics of fPET signals, modelling of the fPET signal is a complex task and poses challenges for accurate interpretation of the results from fPET experiments. This study applied independent component analysis (ICA) to analyse resting state fPET data, and to compare the performance of ICA and the general linear model (GLM) for estimation of brain activation in response to tasks. The fPET signal characteristics were compared using GLM and ICA methods to model fPET data from a visual activation experiment. Our aim was to evaluate GLM and ICA methods for analysing task fPET datasets, and to apply ICA methods to the analysis of resting state fPET datasets. Using both simulation and in-vivo experimental datasets, we show that both ICA and GLM methods can successfully identify task related brain activation. We report fPET metabolic resting state brain networks revealed by application of the fPET ICA method to a cohort of 28 healthy subjects. Functional PET provides a unique method to map dynamic changes of glucose uptake in the resting human brain and in response to extrinsic stimulation.

Reversible optical binding force in a plasmonic heterodimer under radially polarized beam illumination.

We investigated the optical binding force in a plasmonic heterodimer structure consisting of two nano-disks. It is found that when illuminated by a tightly focused radially polarized beam (RPB), the plasmon modes of the two nano-disks are strongly hybridized, forming bonding/antibonding modes. An interesting observation of this setup is that the direction of the optical binding force can be controlled by changing the wavelength of illumination, the location of the dimer, the diameter of the nano-disks, and the dimer gap size. Further analysis yields that the inhomogeneous polarization state of RPB can be utilized to readily control the bonding type of plasmon modes and distribute the underlying local field confined in the gap (the periphery) of the dimer, leading to a positive (negative) optical binding force. Our findings provide a clear strategy to engineer optical binding forces via changes in device geometry and its illumination profile. Thus, we envision a significant role for our device in emerging nanophotonics structures.

Unidirectional scattering exploited transverse displacement sensor with tunable measuring range.

We propose a scheme to extend the measuring range of a transverse displacement sensor by exploiting the interaction of an azimuthally polarized beam (APB) with a single metal-dielectric core-shell nanoparticle. The focused APB illumination induces a longitudinal magnetic dipole (MD) in the core-shell nanoparticle, which interferes with the induced transverse electric dipole (ED) to bring forth a transverse unidirectional scattering at a specific position within the focal plane. Emphatically, the rapidly varying electromagnetic field within the focal plane of an APB leads to a remarkable sensitivity of the far-field scattering directivity to nanoscale displacements as the nanoparticle moves away from the optical axis. Moreover, the scattering directivity of the APB illuminated core-shell nanoparticle is also a function of structure-dependent Mie scattering coefficients, rendering the measuring range of the transverse displacement sensor widely tunable. The culmination of all these features enables the continuous tuning of the displacement measuring range from several nanometers to a few micrometers. Thus, we envision the proposed scheme is of high value for modern optical nanometrology.

Radial breathing modes coupling in plasmonic molecules.

Metallic hexamer, very much the plasmonic analog of benzene molecule, provides an ideal platform to mimic modes coupling and hybridization in molecular systems. To demonstrate this, we present a detailed study on radial breathing mode (RBM) coupling in a plasmonic dual-hexamers. We excite RBMs of hexamers by symmetrically matching the polarization state of the illumination with the distribution of electric dipole moments of the dual-hexamer. It is found that the RBM coupling exhibits a nonexponential decay when the inter-hexamer separation is increased, owing to the dark mode nature of RBM. When the outer hexamer is subjected to the in-plane twisting, resonant wavelengths of two coupled RBMs as well as the coupling constant show cosine variations with the twist angle, indicating the symmetry of hexamer structure plays a critical role in the coupling of RBMs. Moreover, it is demonstrated that the coupling of RBMs is dominated by the in-plane interaction as the outer hexamer is under an out-of-plane tilting, causing convergence of resonant wavelengths of the two coupled RBMs with increasing tilt angle. Our results not only provide an insight into the plasmonic RBM coupling mechanism, but also pave the way to systematically control the spectral response of plasmonic molecules.

Enhanced second-harmonic generation assisted by breathing mode in a multi-resonant plasmonic trimer.

Boosting the nonlinear conversion rate in nanoscale is pivotal for practical applications such as highly sensitive biosensors, extreme ultra-violate light sources, and frequency combs. Here, we theoretically study the enhancement of second-harmonic generation (SHG) in a plasmonic trimer assisted by breathing modes. The geometry of the trimer is fine-tuned to produce strong plasmonic resonances at both the fundamental and SH wavelengths to boost SHG intensity. Moreover, it is found that breathing modes show remarkable ability to augment SHG by increasing the enhancement area. In particular, these breathing modes ensure a substantial spatial mode overlap at the fundamental and SH wavelengths, resulting in further promotion of the SHG conversation rate. We envision that our findings could enable applications in nanoscale frequency converters with high efficiency.

Machine learning based temperature prediction of poly(N-isopropylacrylamide)-capped plasmonic nanoparticle solutions.

The temperature-dependent optical properties of gold nanoparticles that are capped with the thermo-sensitive polymer: 'poly(N-isopropylacrylamide)' (PNIPAM), have been studied extensively for several years. Also, their suitability to function as nanoscopic thermometers for bio-sensing applications has been suggested numerous times. In an attempt to establish this, many have studied the temperature-dependent optical resonance characteristics of these particles; however, developing a simple mathematical relationship between the optical measurements and the solution temperature remains an open challenge. In this paper, we attempt to systematically address this problem using machine learning techniques to quickly and accurately predict the solution-temperature, based on spectroscopic data. Our emphasis is on establishing a simple and practically useful solution to this problem. Our dataset comprises spectroscopic absorption data from both nanorods and nanobipyramids capped with PNIPAM, measured at discretely varied and pre-set temperature states. Specific regions of the spectroscopic data are selected as features for prediction using random forest (RF), gradient boosting (GB) and adaptive boosting (AB) regression techniques. Our prediction results indicate that RF and GB techniques can be used successfully to predict solution temperatures instantly to within 1 °C of accuracy.

Water metamaterial for ultra-broadband and wide-angle absorption.

A subwavelength water metamaterial is proposed and analyzed for ultra-broadband perfect absorption at microwave frequencies. We experimentally demonstrate that this metamaterial shows over 90% absorption within almost the entire frequency band of 12-29.6 GHz. It is also shown that the proposed metamaterial exhibits a good thermal stability with its absorption performance almost unchanged for the temperature range from 0 to 100°C. The study of the angular tolerance of the metamaterial absorber shows its ability of working at wide angles of incidence. Given that the proposed water metamaterial absorber is low-cost and easy for manufacture, we envision it may find numerous applications in electromagnetics such as broadband scattering reduction and electromagnetic energy harvesting.

Sub-10 nm particle trapping enabled by a plasmonic dark mode.

We demonstrate that a highly localized plasmonic dark mode with radial symmetry, termed quadrupole-bonded radial breathing mode, can be used for optically trapping the dielectric nanoparticles. In particular, the annular potential well produced by this dark mode shows a sufficiently large depth to stably trap the 5 nm particles under a relatively low optical power. Our results address the quest for precisely trapping sub-10 nm particles with high yield and pave the way for placing sub-10 nm particles conforming to a specific geometric pattern.

Spawning a ring of exceptional points from a metamaterial.

Exceptional points(EPs) are degeneracies in non-Hermitian systems and give rise to counter intuitive, yet interesting physical effects. Inspired by the exotic physics of EP in designed metamaterials, we theoretically explore how an EPs-ring can be generated from a non-Hermitian resonant metamaterial bearing both dissipation and radiation losses. When the substrate thickness of this metamaterial is varied, the complex eigenvalues of the scattering matrix show a transition from single EP to a ring of EPs, where each EP is associated with maximally asymmetric reflection. We show that our scattering matrix based fitted coupled mode theory results agree very well with finite-difference time-domain simulations. Our work illustrates that the optical properties of the metamaterials can be dramatically altered by carefully tuning the dissipation and radiation losses.

Multiband coherent perfect absorption in a water-based metasurface.

We design an ultrathin water-based metasurface capable of coherent perfect absorption (CPA) at radio frequencies. It is demonstrated that such a metasurface can almost completely absorb two symmetrically incident waves within four frequency bands, each having its own modulation depth of metasurface absorptivity. Specifically, the absorptivity at 557.2 MHz can be changed between 0.59% and 99.99% via the adjustment of the phase difference between the waves. The high angular tolerance of our metasurface is shown to enable strong CPA at oblique incidence, with the CPA frequency almost independent of the incident angle for TE waves and varying from 557.2 up to 584.2 MHz for TM waves. One can also reduce this frequency from 712.0 to 493.3 MHz while retaining strong coherent absorption by varying the water layer thickness. It is also show that the coherent absorption performance can be flexibly controlled by adjusting the temperature of water. The proposed metasurface is low-cost, biocompatible, and useful for electromagnetic modulation and switching.

Wideband visible-light absorption in an ultrathin silicon nanostructure.

We design a new kind of metamaterial absorber in the form of an ultrathin silicon nanostructure capable of having wideband absorption of visible light. We show that our metamaterial can exhibit almost perfect absorption of incident light even though its thickness is several tens of times smaller than the optical wavelength. The combination of two resonant modes in a single nanostructure allows us to achieve absorptivities exceeding 80% in a wide band spanning from 437.9 to 578.3 nm. The physical origins of the two modes, elucidated via the analysis of current distribution inside the nanostructure, explain different metamaterial absorptivities for oblique incidence of TE- and TM-polarized waves. Our study opens a new prospect in designing ultrathin, yet wideband visible-light absorbers based on silicon.

Controlling resonance energy transfer in nanostructure emitters by positioning near a mirror.

The ability to control light-matter interactions in quantum objects opens up many avenues for new applications. We look at this issue within a fully quantized framework using a fundamental theory to describe mirror-assisted resonance energy transfer (RET) in nanostructures. The process of RET communicates electronic excitation between suitably disposed donor and acceptor particles in close proximity, activated by the initial excitation of the donor. Here, we demonstrate that the energy transfer rate can be significantly controlled by careful positioning of the RET emitters near a mirror. The results deliver equations that elicit new insights into the associated modification of virtual photon behavior, based on the quantum nature of light. In particular, our results indicate that energy transfer efficiency in nanostructures can be explicitly expedited or suppressed by a suitably positioned neighboring mirror, depending on the relative spacing and the dimensionality of the nanostructure. Interestingly, the resonance energy transfer between emitters is observed to "switch off" abruptly under suitable conditions of the RET system. This allows one to quantitatively control RET systems in a new way.

Optical Bloch oscillations and Zener tunneling of Airy beams in ionic-type photonic lattices.

We report on the existence of optical Bloch oscillations (OBOs) and Zener tunneling (ZT) of Airy beams in ionic-type photonic lattices with a refractive index ramp. Different from their counterparts in uniform lattices, Airy beams undergoing OBOs show an alternatively switched concave and convex trajectory as well as a periodical revival of input beam profiles. Moreover, the ionic-type photonic lattice established in photorefractive crystal exhibits a reconfigurable lattice structure, which provides a flexible way to tune the amplitude and period of the OBOs. Remarkably, it is demonstrated that the band gap of the lattice can be readily controlled by rotating the lattice inducing beam, which forces the ZT rate to follow two significant different decay curves amidst decreasing index gradient. Our results open up new possibilities for all-optical switching, routing and manipulation of Airy beams.

Theoretical analysis of hot electron injection from metallic nanotubes into a semiconductor interface.

Metallic nanostructures under optical illumination can generate a non-equilibrium high-energy electron gas (also known as hot electrons) capable of being injected into neighbouring media over a potential barrier at particle boundaries. The nature of this process is highly nanoparticle shape and size dependent. Here, we have derived an analytical expression for the frequency dependent rate of injection of these energetic electrons from a metallic nanotube into a semiconductor layer in contact with its inner boundary. In our derivation, we have considered the quantum mechanical motion of the electron gas confined by the particle boundaries in determining the electron energy spectrum and wave functions. We present a comprehensive theoretical analysis of how different geometric parameters such as the outer to inner radius ratio, length and thickness of a nanotube and illumination frequency affect the hot electron injection and internal quantum efficiency of the nanotube. We reveal that longer nanotubes with thin shells and high inner to outer radius ratios show better performance at visible and infrared frequencies. Our derivations and results provide the much needed theoretical insight for optimization of thin nanotubes for different hot electron based applications.

Electrical control of second harmonic generation in a graphene-based plasmonic Fano structure.

We propose a strategy for active control of second harmonic generation (SHG) in a plasmonic Fano structure by electrically doping its underlying monolayer graphene. A detailed theoretical model for the proposed scheme is developed and numerical simulations are carried out to demonstrate the operation. Specifically, we show that a merely 30 meV change in graphene Fermi level can result in 45 times increase in SHG peak intensity, accompanied by a resonance wavelength shift spanning 220 nm. Further analysis uncovers that such tunability in SHG arises from the Fermi-level-modulated graphene permittivity, the real and imaginary parts of which dominate the resonance wavelength and the intensity of SHG, respectively.

Electrically pumped hybrid plasmonic waveguide.

Active plasmonic waveguiding has become a key requirement for designing and implementing nanophotonic devices. We study theoretically the performance of an Au/GaSb-based, metal-insulator-semiconductor (MIS) structure acting as a hybrid electrically pumped waveguide with gain. The surface-plasmon polariton (SPP) mode supported by this configuration is analyzed in the third telecommunication window and discussed in detail. Changes in the effective mode index, confinement factor and effective mode area are illustrated for different core widths and layer thicknesses. Electrical behavior of the MIS junction is analyzed using a self-consistent numerical technique and used to study variations in the material and model gains within the semiconducting region of the device. Our results indicate the possibility of achieving low loss SPP propagation while maintaining a strong field confinement.

Controlling Fano resonance of ring/crescent-ring plasmonic nanostructure with Bessel beam.

We propose a method to dynamically control the Fano resonance of a ring/crescent-ring gold nanostructure by spatially changing the phase distribution of a probe Bessel beam. We demonstrate that a highly tunable Fano interference between the quadrupole and bright dipole modes can be realized in the near-infrared range. Even though a complex interference between a broad resonance and a narrower resonance lead to these observations, we show that a simple coupled oscillator model can accurately describe the behavior, providing valuable insights into the dynamics of the system. A further analysis of this structure uncovers a series of interesting phenomena such as anticrossing, sign changing of coupling and the spectral inversion of quadrupole and bright dipole modes. We further show that near field enhancement at Fano resonance can be actively controlled by modulating the phase distribution of the exciting incident Bessel beam.

Dielectric function of spherical dome shells with quantum size effects.

Metallic spherical dome shells have received much attention in recent years because they have proven to possess highly impressive optical properties. The expected distinctive changes occurring owing to quantum confinement of conduction electrons in these nanoparticles as their thickness is reduced, have not been properly investigated. Here we carry out a detailed analytical derivation of the quantum contributions by introducing linearly shifted Associated Legendre Polynomials, which form an approximate orthonormal eigenbasis for the single-electron Hamiltonian of a spherical dome shell. Our analytical results clearly show the contribution of different elements of a spherical dome shell to the effective dielectric function. More specifically, our results provide an accurate, quantitative correction for the dielectric function of metallic spherical dome shells with thickness below 10 nm.

Low-threshold lasing in photonic-crystal heterostructures.

We study a photonic crystal (PhC) heterostructure cavity consisting of gain medium in a three-dimensional (3D) PhC sandwiched between two identical passive multilayers. For this structure, based on Korringa-Kohn-Rostoker method, we observe a decrease in the lasing threshold of two orders of magnitude, as compared with a stand-alone 3D PhC. We attribute this remarkable decrease in threshold gain to the overlap of the defect cavity mode with the reduced group velocity region of the PhC's dispersion, and the associated enhancement in the distributed feedback from the ordered layers of the PhC. The obtained results show the potency for designing PhC-based, compact on-chip lasers with ultra-low thresholds.

Optical Bloch oscillations of an Airy beam in a photonic lattice with a linear transverse index gradient.

We theoretically report the existence of optical Bloch oscillations (BO) of an Airy beam in a one-dimensional optically induced photonic lattice with a linear transverse index gradient. The Airy beam experiencing optical BO shows a more robust non-diffracting feature than its counterparts in free space or in a uniform photonic lattice. Interestingly, a periodical recurrence of Airy shape accompanied with constant alternation of its acceleration direction is also found during the BO. Furthermore, we demonstrate that the period and amplitude of BO of an Airy beam can be readily controlled over a wide range by varying the index gradient and/or the lattice period. Exploiting these features, we propose a scheme to rout an Airy beam to a predefined output channel without losing its characteristics by longitudinally modulating the transverse index gradient.