Illness representations of coronary artery disease: an empirical examination of the Illness Perceptions Questionnaire (IPQ) in patients undergoing surgery, angioplasty and medication.

BACKGROUND: This study sought to validate empirically, through factor analysis, the theoretically developed Illness Perceptions Questionnaire (IPQ) measure of illness representations, and investigated how illness representations varied within an illness condition between different treatments. METHODS: Two hundred and fourteen coronary artery disease (CAD) patients, 70 of whom were undergoing medication, 71 to undergo angioplasty and 73 to undergo coronary artery bypass surgery (CABG), completed the New Zealand Heart Attack Recovery Project version of the IPQ. The core cognitive illness representation statement responses were subject to principal components analyses (PCA), with oblique rotation. Identity data were examined regarding symptom frequency. Subscales based on factor structures and frequency scores were utilized to investigate treatment group differences in illness beliefs through analysis of covariance (ANCOVA). FINDINGS: PCA of the core components indicated four factors labelled: 'illness impact', 'duration', 'control', and 'self-image', accounting for 46.5% of the variance. The most frequently experienced symptoms were fatigue, breathlessness and chest-pain (angina). ANCOVAs showed significant treatment group differences in frequency of chest-pain experienced (medicationrevascularization groups, p<.001). DISCUSSION: The results produced a modified structure for the IPQ, which appeared to reflect the nature of the illness under study and the possible fractionation of the core illness representation components. Responses on the subscales created were also related to the position within the 'subjective experience with the illness' that a patient had reached and the treatment being undertaken.

Cognitive change 5 years after coronary artery bypass surgery.

A longitudinal study of cognitive function after coronary artery bypass surgery examined 107 participants using 11 tests, preoperatively and at 6 days, 8 weeks, and 5 years after surgery. The overall neuropsychological (NP) change score declined at 6 days, showed some recovery at 8 weeks, and declined again at 5 years. The number of microemboli recorded during surgery, postoperative short-term cognitive change, and degree of recovery at 8 weeks were identified as predictors of change in NP score to 5 years. This suggests that even over a 5-year period, operative damage is detectable. Patients' vulnerability to short-term deterioration and resilience or ability to recover over a few weeks from operative cerebral insult are important processes of unknown mechanisms.

Leucocyte-depleting arterial line filtration does not reduce myocardial injury assessed by Troponin T during routine coronary artery bypass grafting using crossclamp fibrillation.

INTRODUCTION: Leucocyte filtration can reduce inflammation and end-organ damage. The aim of this study was to test the cardioprotective effect of systemic leucocyte filtration during cardiopulmonary bypass (CPB) for coronary revascularization. METHODS: Sixty patients scheduled for elective coronary artery bypass grafting were prospectively randomised to receive either a test leucocyte-depleting (LD) filter or a control standard arterial line filter in the CPB circuit. Myocardial injury was determined by serum Troponin T concentration up to 72 h postoperatively. In addition, perioperative neutrophil counts, serum elastase and electrocardio-grams (ECGs) were evaluated. RESULTS: There was a peak of Troponin T release at 6 h in both groups. There was no difference between LD or control group Troponin T at any time point. No difference in neutrophil count was found. A greater rise in neutrophil elastase occurred in the LD group during CPB and 10 min post CPB (376 and 496 versus 108 and 228 mcg/L, p<0.001). CONCLUSIONS: LD arterial line filters did not confer any cardioprotective effect as measured by Troponin T in elective coronary revascularization cases.

HIV-related aneurysm of the aortic root in a patient outside Africa: a case report.

We report a patient infected with human immunodeficiency virus (HIV) with an aneurysm of the aortic root. No definitive histopathological diagnosis was entertained in this case. Based on the existing literature, we discuss a potential causative relationship between HIV and aortic aneurysm.