RESUMEN
CONTEXT: A polymorphism of the GH receptor (GHR) gene resulting in genomic deletion of exon 3 (GHR-d3) has been associated with responsiveness to GH therapy. However, the data reported so far do vary according to the underlying condition, replacement dose, and duration of the treatment. OBJECTIVE, DESIGN: The aim of this study was to analyze the impact of the GHR genotypes in terms of the initial height velocity (HV) resulting from treatment and the impact upon adult height in patients suffering from severe isolated GH deficiency. CONTROLS, PATIENTS, SETTING: A total of 181 subjects (peak stimulated GHAsunto(s)
Estatura/efectos de los fármacos
, Exones
, Hormona del Crecimiento/uso terapéutico
, Terapia de Reemplazo de Hormonas
, Hormona de Crecimiento Humana/deficiencia
, Receptores de Somatotropina/genética
, Adulto
, Femenino
, Eliminación de Gen
, Genotipo
, Humanos
, Modelos Lineales
, Masculino
, Persona de Mediana Edad
, Isoformas de Proteínas