Review on Natural Bioactive Products as Radioprotective Therapeutics: Present and Past Perspective.

Among conventional treatment methodologies, surgery, hyperthermia, radiation, and chemotherapy have become integral components of treatment for most cancers. Radiation therapy in the treatment of many malignancies is always the better choice over surgery and chemotherapy. Ionizing radiation produced as a consequence of using these radiations has always been a concern in these treatment methods. Synthetic radio-protectors with their inherent limitations are being used to date to reduce the mortality of these radiations; still, it compromises the clinical efficacy of these administrations. Hence, investigations for alternative methods, including natural resources such as plant and fruit extracts, are being explored to treat radiation-mediated ailments. The present review article endeavors to provide a comprehensive, updated, and chronological account of these promising plants and fruit extracts and their bioactive principles as radio-protectors. We present the merits and demerits of radiation therapy and cell stress generation of reactive oxygen species (ROS) associated with radiation need and availability of radio-protectors. Finally, we discuss green-based bioactive compounds that have radioprotective properties.

Bibliometric analysis on exploitation of biogenic gold and silver nanoparticles in breast, ovarian and cervical cancer therapy.

Multifunctional nanoparticles are being formulated to overcome the side effects associated with anticancer drugs as well as conventional drug delivery systems. Cancer therapy has gained the advancement due to various pragmatic approaches with better treatment outcomes. The metal nanostructures such as gold and silver nanoparticles accessible via eco-friendly method provide amazing characteristics in the field of diagnosis and therapy towards cancer diseases. The environmental friendly approach has been proposed as a substitute to minimize the use of hazardous compounds associated in chemical synthesis of nanoparticles. In this attempt, researchers have used various microbes, and plant-based agents as reducing agents. In the last 2 decades various papers have been published emphasizing the benefits of the eco-friendly approach and advantages over the traditional method in the cancer therapy. Despite of various reports and published research papers, eco-based nanoparticles do not seem to find a way to clinical translation for cancer treatment. Present review enumerates the bibliometric data on biogenic silver and gold nanoparticles from Clarivate Analytics Web of Science (WoS) and Scopus for the duration 2010 to 2022 for cancer treatment with a special emphasis on breast, ovarian and cervical cancer. Furthermore, this review covers the recent advances in this area of research and also highlights the obstacles in the journey of biogenic nanodrug from clinic to market.

Recycling/reuse of plastic waste as construction material for sustainable development: a review.

The exponential rise in the production of plastic and the consequential surge in plastic waste have led the scientists and researchers look out for innovative and sustainable means to reuse/recycle the plastic waste in order to reduce its negative impact on environment. Construction material, converting waste plastic into fuel, household goods, fabric and clothing are some of the sectors where waste plastic is emerging as a viable option. Out of these, construction material modified with plastic waste has garnered lot of attention. Modification of construction material with plastic waste serves a dual purpose. It reduces the amount of plastic waste going to landfills or litter and secondly lessens the use of mined construction materials, thereby mitigating the negative impact of construction industry on environment. This paper summarizes the developments with regard to the use of plastic waste as a constituent of construction material. Inclusion of plastic waste as a binder, aggregate, fine aggregate, modifier or substitute of cement and sand in the manufacturing of bricks, tiles, concrete and roads has been comprehensively reviewed. Also, the influence of addition of plastic waste on strength properties, water absorption, durability, etc. has been thoroughly discussed. The research studies considered for this review have been categorized based on whether they dealt with the use of plastic waste for bricks and tiles or in concrete for road construction.