RESUMEN
A small subset of patients with antiphospholipid syndrome (APS) may develop widespread thrombotic disease with organ damage, referred to as catastrophic APS (CAPS) that is associated with a high mortality. Medical therapy typically involves a combination of anticoagulation, systemic glucocorticoids, plasmapheresis, and intravenous immune globulin (IVIG). There is currently no consensus for the management of refractory cases of CAPS. However, monoclonal antibodies such as rituximab and eculizumab have shown some benefits. Herein, we present a 29-year-old female with previous pulmonary embolism who presented with necrotic left toes and was eventually diagnosed with refractory CAPS, successfully treated with Plasmapheresis and Rituximab. With this case report, we hope to encourage the usage of Rituximab in the management of CAPS.
RESUMEN
Solid cystic hidradenoma, or clear cell hidradenoma, is a distinct and histologically rare tumor formed at the sweat glands, found mainly in adults and majorly among women. In this case, a 26-year-old female presented with asymptomatic swelling in her left inguinal area. Similar cases have been discussed in the literature considering the same kind of tumor. The present case is reported owing to the rarity of the type of tumor in terms of size and region of occurrence with the associated condition of pregnancy.
RESUMEN
Kartagener's syndrome (KS) is a rare hereditary disease. It is a triad of chronic sinusitis bronchiectasis and situs inversus. The condition is probably underdiagnosed and the symptoms are more prevalent in children in their first decade of life. We describe a case of a 22-year-old female with a history of cough and dyspnea for six months. The patient was diagnosed with dextrocardia at birth and had no significant medical history for the first two decades of her life. She was adequately immunized during her infancy and childhood as per the National Immunization Program. She was also vaccinated with the SARS-CoV-2 vaccine along with the booster dose. She was diagnosed with KS depending on her clinical symptoms, imaging characteristics and demographics. The patient had received symptomatic treatment for six months before developing respiratory distress requiring hospitalization when the diagnosis was made. KS has to be taken into consideration if an individual with dextrocardia has recurrent upper or lower respiratory tract infections. An early and accurate diagnosis of this illness is crucial to avoid complications and improve the quality of life of patients.