RESUMEN
The World Health Organization's 5th edition classification of Central Nervous System (CNS) tumors differentiates diffuse gliomas into adult and pediatric variants. Pediatric-type diffuse low-grade gliomas (pDLGGs) are distinct from adult gliomas in their molecular characteristics, biological behavior, clinical progression, and prognosis. Various molecular alterations identified in pDLGGs are crucial for treatment. There are four distinct entities of pDLGGs. All four of these tumor subtypes exhibit diffuse growth and share overlapping histopathological and imaging characteristics. Molecular analysis is essential for differentiating these lesions.
RESUMEN
Post-hematopoietic stem cell transplant secondary solid neoplasms are uncommon and usually host-derived. We describe a 6-year-old female who developed a mixed donor-recipient origin mesenchymal stromal tumor-like lesion in the liver following an unrelated hematopoietic stem cell transplant complicated by severe graft-versus-host disease. This lesion arose early post-transplant in association with hepatic graft-versus-host disease. At 12 years post-transplant, the neoplasm has progressively shrunken in size and the patient remains well with no neoplasm-associated sequelae. This report characterizes a novel lesion of mixed origin post-transplant and offers unique insights into the contribution of bone marrow-derived cells to extra-medullary tissues.
Asunto(s)
Trasplante de Células Madre Hematopoyéticas/efectos adversos , Neoplasias Hepáticas/etiología , Hígado/patología , Células Madre Mesenquimatosas/patología , Leucemia-Linfoma Linfoblástico de Células Precursoras B/terapia , Proliferación Celular , Niño , Femenino , Enfermedad Injerto contra Huésped/complicaciones , Humanos , Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/patología , Leucemia-Linfoma Linfoblástico de Células Precursoras B/complicaciones , Trasplante HomólogoAsunto(s)
Anafilaxia , Hipersensibilidad a las Drogas , Trasplante de Células Madre Hematopoyéticas , Anafilaxia/diagnóstico , Anafilaxia/etiología , Desensibilización Inmunológica/métodos , Hipersensibilidad a las Drogas/diagnóstico , Hipersensibilidad a las Drogas/terapia , Trasplante de Células Madre Hematopoyéticas/efectos adversos , Humanos , Vidarabina/análogos & derivadosAsunto(s)
Antifúngicos/uso terapéutico , Criptococosis/diagnóstico , Cryptococcus neoformans/aislamiento & purificación , Deficiencia de IgG/complicaciones , Adolescente , Encéfalo/diagnóstico por imagen , Líquido Cefalorraquídeo/microbiología , Criptococosis/complicaciones , Criptococosis/tratamiento farmacológico , Humanos , Inmunoglobulina G/sangre , Imagen por Resonancia Magnética , Masculino , Piel/microbiología , Piel/patologíaRESUMEN
This case report demonstrates that hypofractionated partial-brain radiation therapy with limited margins is a reasonable approach following gross tumor resection of Ewing sarcoma metastases to the brain. The patient presented with 2 intracranial metastases treated with gross-total resection followed by radiation therapy to 30 Gy in 5 fractions. The patient experienced symptomatic treatment-related inflammatory changes with resolution after receiving dexamethasone. He remains alive at 21 months of follow-up with no evidence of disease.
Asunto(s)
Neoplasias Encefálicas , Hipofraccionamiento de la Dosis de Radiación , Radioterapia Adyuvante/métodos , Sarcoma de Ewing/patología , Neoplasias Encefálicas/tratamiento farmacológico , Neoplasias Encefálicas/radioterapia , Neoplasias Encefálicas/secundario , Neoplasias Encefálicas/cirugía , Niño , Humanos , MasculinoRESUMEN
Costus igneus Nak and Costus pictus D. Don, commonly known as Spiral flag, is a member of Costaceae and a newly introduced plant in India from South and Central America. It is a perennial, upright, spreading plant reaching about two feet tall, with spirally arranged leaves and attractive flowers. In southern India, it usually grows as an ornamental plant and its leaves are used as a dietary supplement in the treatment of diabetes mellitus. Recently, a number of researches have been carried out to evaluate the anti-diabetic potential of this plant. Besides, it has been proven to possess various pharmacological activities like hypolipidemic, diuretic, antioxidant, anti-microbial, anti-cancerous. Further, various phytochemical investigations reveal the presence of carbohydrates, triterpenoids, proteins, alkaloids, tannins, saponins, flavonoids, steroid, and appreciable amounts of trace elements. This work is an attempt to compile and explore the different pharmacological and phytochemical studies reported till date.