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1.
Eur J Orthop Surg Traumatol ; 25(4): 655-60, 2015 May.
Artículo en Inglés | MEDLINE | ID: mdl-25260576

RESUMEN

Cemented Thompson's prostheses have been used to treat elderly patients with displaced intracapsular hip fractures at our two units for the last 15 years, amid growing support for the use of newer implant designs for hip hemiarthroplasty. This provided us with an opportunity to investigate survival of the Thompson's stem in our patients. A retrospective cohort study was set up to review previously collected data on patients who underwent Thompson's hemiarthroplasty over a 7-year period. These were linked to surgical notes, clinical letters and radiographs to record post-operative course and subsequent admissions and procedures. The identifiers were then linked to mortality data from the Office of 'National Statistics. Kaplan-Meier survival analyses were done for implants and patients. A total of 1,632 patients (mean age 82.7 years) underwent 1,670 procedures. Five-year implant survival was 95.4 %. A total of 36 stems were revised, including 14 revisions to total hip arthroplasty and 22 excision arthroplasties. Reasons for revision included infection (2.1 %), dislocation (1.1 %) and aseptic loosening (0.5 %). Symptomatic aseptic loosening and acetabular erosion occurred late (mean time 3.2 and 5.7 years, respectively following surgery). Aseptic loosening and erosion following hemiarthroplasty are relatively late complications.


Asunto(s)
Artroplastia de Reemplazo de Cadera/métodos , Cementos para Huesos/uso terapéutico , Fracturas del Cuello Femoral/cirugía , Hemiartroplastia/métodos , Anciano , Anciano de 80 o más Años , Artroplastia de Reemplazo de Cadera/mortalidad , Fracturas del Cuello Femoral/diagnóstico por imagen , Fracturas del Cuello Femoral/mortalidad , Hemiartroplastia/mortalidad , Prótesis de Cadera , Humanos , Estimación de Kaplan-Meier , Persona de Mediana Edad , Falla de Prótesis , Infecciones Relacionadas con Prótesis/diagnóstico por imagen , Infecciones Relacionadas con Prótesis/mortalidad , Radiografía , Reoperación/mortalidad , Estudios Retrospectivos
2.
Ir Med J ; 107(4): 112-4, 2014 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-24834584

RESUMEN

The e-logbook is used to monitor progression through training and to assess training within teaching units. We document consultant and trainee opinions with regards to supervision status, and to inform guidelines for trainees and trainers using the e-logbook. A questionnaire was sent to consultants and trainees in the UK and Ireland. Eight theatre scenarios were described and respondents were asked to state what they felt was the appropriate supervision status for the trainee. Significantly more consultants in the UK use the e-logbook than those based in Ireland (58.5%:14.5%). There were differences in consensus response to the scenarios between consultants and trainees, and between Irish and UK based surgeons. We have documented the opinions of consultants and trainees from across the UK and Ireland with regards to supervision status for trainees under certain theatre situations. This information should support formal guidelines for all users of the logbook.


Asunto(s)
Actitud del Personal de Salud , Consultores/psicología , Cirugía General/organización & administración , Estudiantes de Medicina/psicología , Humanos , Irlanda , Procedimientos Quirúrgicos Operativos , Encuestas y Cuestionarios , Reino Unido , Recursos Humanos
3.
Surgeon ; 11(1): 20-4, 2013 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-22709532

RESUMEN

BACKGROUND: The reduction of Clostridium difficile associated diarrhoea (CDAD) is a national priority. As part of the C. difficile improvement plan in our Trust, antibiotic prophylaxis for primary arthroplasty was changed from cefuroxime to gentamicin. Gentamicin was chosen following a review of the sensitivity profiles of all the organisms isolated from infected primary arthoplasties. METHODS: From January 2002 to September 2007, 6094 patients (Group 1) undergoing primary hip and knee arthroplasty received three doses of Cefuroxime as prophylaxis; while from October 2007 to February 2009, 2101 patients (Group 2) received single dose Gentamicin (4.5 mg/kg). We studied the rate of CDAD as well as several other postoperative complications, including rate of return to theatre (RTT), before and after the change. FINDINGS: There was an insignificant fall in CDAD from 0.18% to 0% (p=0.08) in Group 2, however there was a statistically significant increase in pneumonia (0.67-1.33%, p<0.01), acute renal failure (ARF) requiring HDU admission (0.07-0.33%, p<0.01) and RTT (1.08-1.95%, p<0.01) in this group. RTT for proven infection increased from 0.66% to 1.52% (p<0.01). CONCLUSIONS: We conclude that Gentamicin 4.5 mg/kg alone should not be used as prophylaxis for primary joint arthroplasty as it does not reduce CDAD significantly but increases the risk of other postoperative complications. We have changed our prophylaxis to low dose gentamicin (3 mg/kg) combined with Teicoplanin 400 mg given once.


Asunto(s)
Antibacterianos/uso terapéutico , Profilaxis Antibiótica/métodos , Artroplastia de Reemplazo de Rodilla , Bacterias/aislamiento & purificación , Infección de la Herida Quirúrgica/prevención & control , Anciano , Femenino , Estudios de Seguimiento , Humanos , Incidencia , Masculino , Estudios Retrospectivos , Infección de la Herida Quirúrgica/epidemiología , Infección de la Herida Quirúrgica/microbiología , Reino Unido/epidemiología
4.
J Orthop Sci ; 18(6): 1027-30, 2013 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-23943223

RESUMEN

BACKGROUND: Arthroplasty surgeons are increasingly using personal protection systems with helmets. It is theoretically possible for the fans in these helmets to blow squames, sweat droplets and orobronchial fomites onto the surgical site. A controlled experiment was set up to investigate the effect of different surgical gowns on counts of airborne particles measuring ≥0.3 µm, using a hand-held particle counter. METHODS: The clothing that was sequentially tested included the following: 1. Barrier(®) surgical gown (single use) made from nonwoven polypropylene (Mölnlycke Health Care Ltd, Dunstable, UK) 2. Stryker(®) T5 Helmet (reusable) covered with a disposable Stryker(®) T4/T5 urethane hood worn separate to and enclosed by the Barrier(®) surgical gown both at the front and back 3. Stryker(®) T5 Helmet (reusable) worn within a disposable Stryker(®) T4/T5 urethane zippered toga (Stryker Corporation, Kalamazoo, MI, USA) Six readings were taken for each of the following three setups in a randomised order: 1. Gown: surgeon with surgical gown and face mask 2. Hood: surgeon with surgical gown and hood, maximum fan speed 3. Toga: surgeon with toga, maximum fan speed Wilcoxon rank sum tests were applied to assess equality of means between the three occlusive measures (gown, hood, toga). P values were computed based upon one-sided tests and adjusted for multiple comparisons using the Bonferroni correction. RESULTS: The mean particle counts (over more than 5 L of air) for the three set-ups were: gown: 1178 (least protective), hood: 328, toga: 42 (most protective). There was a significant reduction in particle counts for the toga versus gown (p = 0.007) and toga versus hood (p = 0.037); differences in particle counts were not significant between the hood and gown (p = 0.140). CONCLUSIONS: The fans in the helmets do not increase contaminants by blowing particles from the head area. A significant reduction in surgeon-originated contaminants was seen with the toga compared to both the hood/gown separate ensemble and gowns alone.


Asunto(s)
Monitoreo del Ambiente/métodos , Dispositivos de Protección de la Cabeza , Material Particulado/análisis , Ropa de Protección , Contaminantes Atmosféricos/efectos adversos , Contaminantes Atmosféricos/análisis , Infección Hospitalaria/prevención & control , Ambiente Controlado , Femenino , Humanos , Masculino , Concentración Máxima Admisible , Quirófanos , Procedimientos Ortopédicos/efectos adversos , Procedimientos Ortopédicos/métodos , Material Particulado/efectos adversos , Estadísticas no Paramétricas , Infección de la Herida Quirúrgica/prevención & control
5.
Pharmacogenomics J ; 12(3): 246-54, 2012 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-21173788

RESUMEN

The goal of this study was to identify genetic markers associated with LY2140023 monohydrate response in patients with schizophrenia. Variants in eight candidate genes related to the mechanism of action of LY2140023 or olanzapine were investigated in a genetic cohort collected from two clinical trials. Results from this genetic analysis indicate that 23 single nucleotide polymorphisms (SNPs) were associated with a change in Positive and Negative Syndrome Scale total score in response to LY2140023 at 28 days (P<0.01; false discovery rate <0.2). Sixteen of these SNPs were located in the serotonin 2A receptor (HTR2A). Bioinformatic analyses identified a putative antisense nested gene in intron 2 of HTR2A in the region of the genetic markers associated with LY2140023 response. These data suggest a genetic association exists between SNPs in several genes, such as HTR2A, and response to LY2140023 treatment. Additional clinical trials are needed to establish replication of these results.


Asunto(s)
Aminoácidos/uso terapéutico , Antipsicóticos/uso terapéutico , Benzodiazepinas/uso terapéutico , Agonistas de Aminoácidos Excitadores/uso terapéutico , Polimorfismo de Nucleótido Simple , Receptores de Glutamato Metabotrópico/agonistas , Esquizofrenia/tratamiento farmacológico , Adulto , Femenino , Haplotipos , Humanos , Intrones , Masculino , Neurregulina-1/genética , Olanzapina , Farmacogenética , Fenotipo , Receptor de Serotonina 5-HT2A/genética , Receptores de Glutamato Metabotrópico/genética , Receptores de Glutamato Metabotrópico/metabolismo , Federación de Rusia , Esquizofrenia/diagnóstico , Esquizofrenia/genética , Esquizofrenia/metabolismo , Psicología del Esquizofrénico , Resultado del Tratamiento , Estados Unidos
6.
EFORT Open Rev ; 7(5): 305-311, 2022 05 05.
Artículo en Inglés | MEDLINE | ID: mdl-35510742

RESUMEN

Purpose: Vitamin D deficiency has been linked to poorer outcomes following hip (THR) and knee (TKR) replacement. We review the effect of peri-operative supplementation on clinical and patient-reported outcomes following THR/TKR. Methods: This study was registered with PROSPERO (CRD42021238086). Searches of electronic databases were performed from inception to March 2021. All randomised, cohort, or case-controlled studies reported in English of adults undergoing THR/TKR where vitamin D supplementation was given peri-operatively and at least one outcome was reported were included. Studies reporting on vitamin D in relation to osteoporosis and hip fracture were excluded, as were conference abstracts and those involving preclinical models. Risks of bias were performed using the RoB-2 and ROBINS-I tools. Results: Three studies comprising 413 TKR patients were identified; two were randomised controlled trials and one was a prospective cohort study. No studies meeting the inclusion criteria reported on the outcomes following THR. Supplementation was associated with a statistically significant reduction in the IL6:IL10 ratio at 24- and 48h following surgery, but no effect was noted on Western Ontario and McMaster Universities Osteoarthritis Index scores or the rates of falls. All studies were judged to be limited by bias, with heterogeneity in the supplementation dose and timing of administration, as well as the reported outcome measures used. Discussion: Further adequately powered randomised-controlled trials using vitamin D supplementation and a specific clinically relevant or patient-reported outcome measure are required to assess if pre-operative vitamin D insufficiency is a modifiable risk factor to improve outcomes following THR/TKR.

7.
Surgeon ; 9(1): 18-21, 2011 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-21195326

RESUMEN

Obesity is an increasing health concern in developed world. Bariatric surgery is considered in super-obese patients. Many of these patients will also require lower limb arthroplasty. This study was performed to investigate the complications of hip and knee replacement in patients who had bariatric surgery either before or after their joint replacement. Hospital episode statistics data for English NHS patients undergoing lower limb arthroplasty and bariatric surgery between 2005 and 2009 were analysed. The joint replacement-specific and general medical complications were compared between those undergoing joint replacement prior to bariatric surgery and vice versa, and also with the general English arthroplasty patient. One hundred and forty-three patients underwent bariatric surgery and joint replacement. Bariatric surgery was performed first in 53 and arthroplasty first in 90 patients. The mean age of obese patients was 9 years younger than the general arthroplasty population. Mean in-hospital stay was similar but general medical complications in obese patients appear to be less, possibly because of the lower age at the time of the procedure. Hip dislocation rate at 18 months was higher. Within the two obese groups wound infection rate was 3.5 times lower and readmission to hospital at 30 days appeared to be 7-times lower in patients who had bariatric surgery prior to joint replacement (p = 0.06). In this patient group, the risk of complications following joint replacement appears to be lower if bariatric surgery is performed first.


Asunto(s)
Artroplastia de Reemplazo de Cadera/efectos adversos , Artroplastia de Reemplazo de Rodilla/efectos adversos , Cirugía Bariátrica , Obesidad Mórbida/cirugía , Complicaciones Posoperatorias/prevención & control , Humanos , Persona de Mediana Edad
8.
Arch Orthop Trauma Surg ; 131(4): 455-8, 2011 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-20607254

RESUMEN

INTRODUCTION: Any increase in perforations in surgical gloves is a concern. We conducted a prospective study to find a clinically acceptable brand of latex-free gloves suitable for orthopaedic surgery. METHOD: Five different brands of gloves approved for use were selected. Two of the latex-free gloves were rejected as their clinical usability in arthroplasty was poor. The Cardinal Esteem latex-free glove has a smooth surface and was slippery, especially in total knee arthroplasty. The Biogel Skin Sense under glove was found to be unacceptably thick, affecting both surgical dexterity and tactility. RESULTS: The three remaining gloves were Biogel latex (control), Synthesis Polyco (latex-free) and Cardinal Esteem SMT (latex-free). Gloves were then collected for testing from 241 arthroplasties. Gloves used for primary knee/hip replacements were tested using a validated water distension test. Latex-free gloves were found to have higher perforation rates compared to latex. CONCLUSION: Our study demonstrates that currently available latex-free gloves have inferior clinical performance and are not recommended for use in arthroplasty surgery.


Asunto(s)
Artroplastia de Reemplazo de Cadera , Artroplastia de Reemplazo de Rodilla , Guantes Quirúrgicos , Acrilonitrilo/análogos & derivados , Diseño de Equipo , Falla de Equipo , Humanos , Compuestos Orgánicos , Estudios Prospectivos , Goma , Estirenos
9.
Surgeon ; 7(4): 243-9, 2009 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-19736893

RESUMEN

The eLogbook is used to collect and collate the operative experience of every orthopaedic trainee in the UK and Ireland. We describe the project and discuss the national data now emerging on elective and trauma training.


Asunto(s)
Educación Médica/organización & administración , Sistemas en Línea , Procedimientos Ortopédicos/educación , Procedimientos Ortopédicos/estadística & datos numéricos , Ortopedia/educación , Traumatología/educación , Competencia Clínica/estadística & datos numéricos , Humanos , Irlanda , Reino Unido
10.
Intern Med J ; 38(10): 781-9, 2008 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-18422565

RESUMEN

Ankylosing spondylitis (AS) is the most common form of spondyloarthropathy. Non-steroidal anti-inflammatory medications and exercise are used to manage the chronic inflammatory spinal pain and stiffness. Up to 20% of patients have a peripheral inflammatory arthritis, which is treated with standard disease-modifying anti-rheumatic drugs especially sulfasalazine and methotrexate. Patients may also have extra-articular manifestations, such as anterior uveitis, psoriasiform skin lesions and inflammatory bowel disease. Anti-tumour necrosis (TNF) therapy has been used with great success in rheumatoid arthritis. There are now good data of the efficacy of anti-TNF therapies in the short and medium terms in AS. Etanercept, infliximab and adalimumab have been shown in randomized placebo-controlled trials of short duration to significantly reduce disease activity, including pain and stiffness as well as improving function, spinal movement and quality of life. It is hoped that long-term therapy will prevent radiologic progression and ankylosis and studies of long-term efficacy are awaited. Anti-TNF therapies are generally well tolerated in AS. It is important to screen for latent tuberculosis before the commencement of anti-TNF therapy. The side-effect profile of anti-TNF therapies in AS does not appear different from that in rheumatoid arthritis. Currently, treatment with anti-TNF therapy in AS is indicated in established disease with radiographic damage. There is evidence that response to therapy is greater in patients with earlier disease and less damage. Future developments may see this therapy extended to patients with pre-radiographic AS.


Asunto(s)
Espondilitis Anquilosante/tratamiento farmacológico , Factor de Necrosis Tumoral alfa/antagonistas & inhibidores , Antiinflamatorios no Esteroideos/uso terapéutico , Etanercept , Humanos , Inmunoglobulina G/uso terapéutico , Ensayos Clínicos Controlados Aleatorios como Asunto/métodos , Receptores del Factor de Necrosis Tumoral/uso terapéutico , Espondilitis Anquilosante/metabolismo , Factor de Necrosis Tumoral alfa/inmunología , Factor de Necrosis Tumoral alfa/metabolismo
11.
Surgeon ; 6(3): 133-5, 2008 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-18581746

RESUMEN

The role of the surgeon is constantly evolving. He or she must adapt to the demands of this increasingly competitive profession and, in doing so, must keep abreast of the changes to the infrastructure of the NHS. One area in which there is currently significant restructuring is finance. In this article we intend to give a brief overview of this financial restructuring and the implications for the surgeon.


Asunto(s)
Cirugía General/organización & administración , Reembolso de Seguro de Salud , Control de Formularios y Registros , Humanos , Registros Médicos , Pautas de la Práctica en Medicina , Reino Unido
12.
Bone Joint J ; 100-B(3): 352-360, 2018 03 01.
Artículo en Inglés | MEDLINE | ID: mdl-29589786

RESUMEN

Aims: This study aimed to compare the change in health-related quality of life of patients receiving a traditional cemented monoblock Thompson hemiarthroplasty compared with a modern cemented modular polished-taper stemmed hemiarthroplasty for displaced intracapsular hip fractures. Patients and Methods: This was a pragmatic, multicentre, multisurgeon, two-arm, parallel group, randomized standard-of-care controlled trial. It was embedded within the WHiTE Comprehensive Cohort Study. The sample size was 964 patients. The setting was five National Health Service Trauma Hospitals in England. A total of 964 patients over 60 years of age who required hemiarthroplasty of the hip between February 2015 and March 2016 were included. A standardized measure of health outcome, the EuroQol (EQ-5D-5L) questionnaire, was carried out on admission and at four months following the operation. Results: Of the 964 patients enrolled, 482 died or were lost to follow-up (50%). No significant differences were noted in EQ-5D between groups, with a mean difference at four months of 0.037 in favour of the Exeter/Unitrax implant (95% confidence interval (CI) 0.014 to 0.087, p = 0.156), rising to 0.045 (95% CI 0.007 to 0.098, p = 0.09) when patients who died were excluded. The minimum clinically important difference for EQ-5D-5L used in this study is 0.08, therefore any benefit between implants is unlikely to be noticeable to the patient. There was no difference in mortality or mobility score. Conclusion: Allowing for the high rate of loss to follow-up, the use of the traditional Thompson hemiarthroplasty in the treatment of the displaced intracapsular hip fracture shows no difference in health outcome when compared with a modern cemented hemiarthroplasty. Cite this article: Bone Joint J 2018;100-B:352-60.


Asunto(s)
Fractura-Luxación/cirugía , Hemiartroplastia/instrumentación , Fracturas de Cadera/cirugía , Prótesis de Cadera , Fracturas Intraarticulares/cirugía , Calidad de Vida , Anciano , Anciano de 80 o más Años , Femenino , Estudios de Seguimiento , Indicadores de Salud , Hemiartroplastia/métodos , Humanos , Modelos Lineales , Masculino , Persona de Mediana Edad , Método Simple Ciego , Resultado del Tratamiento
13.
Bone Joint J ; 100-B(3): 296-302, 2018 03 01.
Artículo en Inglés | MEDLINE | ID: mdl-29589500

RESUMEN

Aims: Surgical site infection (SSI) is a common complication of surgery with an incidence of about 1% in the United Kingdom. Sutures can lead to the development of a SSI, as micro-organisms can colonize the suture as it is implanted. Triclosan-coated sutures, being antimicrobical, were developed to reduce the rate of SSI. Our aim was to assess whether triclosan-coated sutures cause a reduction in SSIs following arthroplasty of the hip and knee. Patients and Methods: This two-arm, parallel, double-blinded study involved 2546 patients undergoing elective total hip (THA) and total knee arthroplasty (TKA) at three hospitals. A total of 1323 were quasi-randomized to a standard suture group, and 1223 being quasi-randomized to the triclosan-coated suture group. The primary endpoint was the rate of SSI at 30 days postoperatively. Results: The baseline characteristics of age, gender and comorbidities were well matched in the two groups. The rates of superficial SSI were 0.8% in the control group and 0.7% in the intervention group (p = 0.651), and when deep and superficial SSIs were combined the rates were 2.5% and 1.8 (p = 0.266). The length of stay in hospital and the rates of medical complications did not differ significantly between the groups (p = 1.000). Conclusion: This trial provided no evidence that the use of triclosan-coated sutures at THA and TKA leads to a reduction in the rate of SSI. Cite this article: Bone Joint J 2018;100-B:296-302.


Asunto(s)
Antiinfecciosos Locales/farmacología , Artroplastia de Reemplazo de Cadera , Artroplastia de Reemplazo de Rodilla , Materiales Biocompatibles Revestidos/farmacología , Infección de la Herida Quirúrgica/prevención & control , Suturas , Triclosán/farmacología , Anciano , Método Doble Ciego , Femenino , Humanos , Incidencia , Masculino , Infección de la Herida Quirúrgica/epidemiología , Resultado del Tratamiento , Reino Unido/epidemiología
14.
J Bone Joint Surg Br ; 89(11): 1427-30, 2007 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-17998176

RESUMEN

This paper considers the new financial infrastructure of the National Health Service and provides a resource for orthopaedic surgeons. We describe the importance of accurate documentation and data collection for National Health Service hospital Trust finances and league tables, and support our discussion with examples drawn from our local audit work.


Asunto(s)
Administración Financiera de Hospitales/economía , Programas Nacionales de Salud/economía , Ortopedia/economía , Recolección de Datos , Grupos Diagnósticos Relacionados , Tabla de Aranceles , Femenino , Humanos , Masculino , Programas Nacionales de Salud/organización & administración , Sistema de Pago Prospectivo , Reino Unido
15.
Bone Joint Res ; 6(8): 506-513, 2017 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-28851695

RESUMEN

OBJECTIVES: The objective of this study was to assess all evidence comparing the Thompson monoblock hemiarthroplasty with modular unipolar implants for patients requiring hemiarthroplasty of the hip with respect to mortality and complications. METHODS: A literature search was performed to identify all relevant literature. The population consisted of patients undergoing hemiarthroplasty of the hip for fracture. The intervention was hemiarthroplasty of the hip with a comparison between Thompson and modular unipolar prostheses.Pubmed, Embase, CINAHL, Web of Science, PROSPERO and the Cochrane Central Register of Controlled Trials.The study designs included were randomised controlled trials (RCTs), well designed case control studies and retrospective or prospective cohort studies. Studies available in any language, published at any time until September 2015 were considered. Studies were included if they contained mortality or complications. RESULTS: The initial literature search identified 4757 items for examination. Four papers were included in the final review. The pooled odds ratio for mortality was 1.3 (95% confidence Interval 0.78 to 2.46) favouring modular designs. The pooled odds ratio for post-operative complications was 1.1 (95% CI 0.79 to 1.55) favouring modular designs. Outcomes were reported at 12 or six months. These papers all contained potential sources of bias and significant clinical heterogeneity. CONCLUSION: The current evidence comparing monoblock versus modular implants in patients undergoing hemiarthroplasty is weak. Confidence intervals around the pooled odds ratios are broad and incorporate a value of one. Direct comparison of outcomes from these papers is fraught with difficulty and, as such, may well be misleading. A well designed randomised controlled trial would be helpful to inform evidence-based implant selection.Cite this article: A. L. Sims, A. J. Farrier, M. R. Reed, T. A. Sheldon. Thompson hemiarthroplasty versus modular unipolar implants for patients requiring hemiarthroplasty of the hip: A systematic review of the evidence. Bone Joint Res 2017;6:-513. DOI: 10.1302/2046-3758.68.BJR-2016-0256.R1.

16.
Trials ; 18(1): 6, 2017 01 09.
Artículo en Inglés | MEDLINE | ID: mdl-28069060

RESUMEN

BACKGROUND: Postoperative knee swelling is common and impairs early postoperative function following total knee arthroplasty. It was hypothesised that the use of a short-stretch, inelastic compression bandage would reduce knee swelling and improve pain and early function. The aim of this study was to provide preliminary data and test feasibility with a view to informing a larger, future trial. METHODS: Fifty consecutive patients selected for primary total knee arthroplasty underwent distance randomisation to receive a short-stretch, inelastic compression bandage or a standard wool and crepe bandage for the first 24 h postoperatively. Study feasibility including recruitment rates, retention rates and complications were analysed. The Oxford Knee Score, the EQ-5D-3L index score, knee swelling, knee range of motion, visual analogue pain score and length of stay were compared between groups. Analysis of covariance (ANCOVA) was performed adjusting for the preoperative measurement. RESULTS: Sixty-eight percent of eligible patients were recruited into the trial. The retention rate was 88%. There were no complications regarding compression bandage use. There was a greater mean but non-significant improvement in Oxford Knee Score (p = 0.580; point estimate = 2.1; 95% CI -3.288 to 7.449) and EQ-5D-3L index score (p = 0.057; point estimate = 0.147; 95% CI -0.328 to 0.005) in the compression bandage group at 6 months. There was no significant difference between groups regarding knee swelling, knee range of motion, visual analogue pain score, complications and length of stay. CONCLUSION: Preliminary data suggests that the use of an inelastic, short-stretch compression bandage following total knee arthroplasty is a safe technique that is acceptable to patients. A larger, multicentre trial is required to determine its effect postoperatively. TRIAL REGISTRATION: The study was registered with Current Controlled Trials, identifier: ISRCTN86903140 . Registered on 30 May 2013.


Asunto(s)
Artroplastia de Reemplazo de Rodilla/efectos adversos , Vendajes de Compresión , Edema/prevención & control , Articulación de la Rodilla/cirugía , Dolor Postoperatorio/prevención & control , Anciano , Análisis de Varianza , Fenómenos Biomecánicos , Vendajes de Compresión/efectos adversos , Edema/diagnóstico , Edema/etiología , Elasticidad , Inglaterra , Diseño de Equipo , Estudios de Factibilidad , Femenino , Humanos , Articulación de la Rodilla/diagnóstico por imagen , Articulación de la Rodilla/fisiopatología , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Dolor Postoperatorio/diagnóstico , Dolor Postoperatorio/etiología , Estudios Prospectivos , Recuperación de la Función , Factores de Tiempo , Resultado del Tratamiento
17.
Bone Joint Res ; 6(8): 499-505, 2017 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-28851694

RESUMEN

OBJECTIVES: We have increased the dose of tranexamic acid (TXA) in our enhanced total joint recovery protocol at our institution from 15 mg/kg to 30 mg/kg (maximum 2.5 g) as a single, intravenous (IV) dose. We report the clinical effect of this dosage change. METHODS: We retrospectively compared two cohorts of consecutive patients undergoing total hip arthroplasty (THA) or total knee arthroplasty (TKA) surgery in our unit between 2008 and 2013. One group received IV TXA 15 mg/kg, maximum 1.2 g, and the other 30 mg/kg, maximum 2.5 g as a single pre-operative dose. The primary outcome for this study was the requirement for blood transfusion within 30 days of surgery. Secondary measures included length of hospital stay, critical care requirements, re-admission rate, medical complications and mortality rates. RESULTS: A total of 1914 THA and 2537 TKA procedures were evaluated. In THA, the higher dose of TXA was associated with a significant reduction in transfusion (p = 0.02, risk ratio (RR) 0.74, 95% confidence interval (CI) 0.58 to 0.96) and rate of re-admission (p < 0.001, RR 0.50, 95% CI 0.35 to 0.71). There were reductions in the requirement for critical care (p = 0.06, RR 0.55, 95% CI 0.31 to 1.00), and in the length of stay from 4.7 to 4.3 days (p = 0.02). In TKA, transfusion requirements (p = 0.049, RR 0.64, 95% CI 0.41 to 0.99), re-admission rate (p = 0.001, RR 0.56, 95% CI 0.39 to 0.80) and critical care requirements (p < 0.003, RR 0.34, 95% CI 0.16 to 0.72) were reduced with the higher dose. Mean length of stay reduced from 4.6 days to 3.6 days (p < 0.01). There was no difference in the incidence of deep vein thrombosis, pulmonary embolism, gastrointestinal bleed, myocardial infarction, stroke or death in THA and TKA between cohorts. CONCLUSION: We suggest that a single pre-operative dose of TXA, 30 mg/kg, maximum 2.5g, results in a lower transfusion requirement compared with a lower dose in patients undergoing elective primary hip and knee arthroplasty. However, these findings should be interpreted in the context of the retrospective non-randomised study design.Cite this article: R. J. M. Morrison, B. Tsang, W. Fishley, I. Harper, J. C. Joseph, M. R. Reed. Dose optimisation of intravenous tranexamic acid for elective hip and knee arthroplasty: The effectiveness of a single pre-operative dose. Bone Joint Res 2017;6:499-505. DOI: 10.1302/2046-3758.68.BJR-2017-0005.R1.

18.
Bone Joint J ; 98-B(3): 410-3, 2016 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-26920968

RESUMEN

AIMS: Our aim, using English Hospital Episode Statistics data before during and after the Distal Radius Acute Fracture Fixation Trial (DRAFFT), was to assess whether the results of the trial affected clinical practice. PATIENTS AND METHODS: Data were grouped into six month intervals from July 2005 to December 2014. All patient episodes in the National Health Service involving emergency surgery for an isolated distal radial fracture were included. RESULTS: Clinical practice in England had not changed in the five years before DRAFFT: 75% of patients were treated with plate fixation versus 12% with Kirschner (K)-wires. After the publication of the trial, the proportion of patients having K-wire fixation rose to 42% with a concurrent fall in the proportion having fixation with a plate to 48%. The proportion of 'other' procedures stayed the same. TAKE HOME MESSAGE: It appears that surgeons in the United Kingdom do change their practice in response to large, pragmatic, multicentre clinical trials in musculoskeletal trauma.


Asunto(s)
Difusión de Innovaciones , Fijación Interna de Fracturas/tendencias , Práctica Profesional/tendencias , Fracturas del Radio/cirugía , Placas Óseas , Hilos Ortopédicos , Inglaterra , Fijación Interna de Fracturas/instrumentación , Fijación Interna de Fracturas/métodos , Fijación Interna de Fracturas/estadística & datos numéricos , Investigación sobre Servicios de Salud/métodos , Humanos , Ensayos Clínicos Pragmáticos como Asunto , Práctica Profesional/estadística & datos numéricos , Ensayos Clínicos Controlados Aleatorios como Asunto , Traumatismos de la Muñeca/cirugía
19.
Bone Joint Res ; 5(1): 18-25, 2016 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-26825319

RESUMEN

BACKGROUND: Approximately half of all hip fractures are displaced intracapsular fractures. The standard treatment for these fractures is either hemiarthroplasty or total hip arthroplasty. The recent National Institute for Health and Care Excellence (NICE) guidance on hip fracture management recommends the use of 'proven' cemented stem arthroplasty with an Orthopaedic Device Evaluation Panel (ODEP) rating of at least 3B (97% survival at three years). The Thompsons prosthesis is currently lacking an ODEP rating despite over 50 years of clinical use, likely due to the paucity of implant survival data. Nationally, adherence to these guidelines is varied as there is debate as to which prosthesis optimises patient outcomes. DESIGN: This study design is a multi-centre, multi-surgeon, parallel, two arm, standard-of-care pragmatic randomised controlled trial. It will be embedded within the WHiTE Comprehensive Cohort Study (ISRCTN63982700). The main analysis is a two-way equivalence comparison between Hemi-Thompson and Hemi-Exeter polished taper with Unitrax head. Secondary outcomes will include radiological leg length discrepancy measured as per Bidwai and Willett, mortality, re-operation rate and indication for re-operation, length of index hospital stay and revision at four months. This study will be supplemented by the NHFD (National Hip Fracture Database) dataset. DISCUSSION: Evidence on the optimum choice of prosthesis for hemiarthroplasty of the hip is lacking. National guidance is currently based on expert opinion rather than empirical evidence. The incidence of hip fracture is likely to continue to increase and providing high quality evidence on the optimumCite this article: A. L. Sims. The World Hip Trauma Evaluation Study 3: Hemiarthroplasty Evaluation by Multicentre Investigation - WHITE 3: HEMI - An Abridged Protocol. Bone Joint Res 2016;5:18-25. doi: 10.1302/2046-3758.51.2000473.

20.
Ann R Coll Surg Engl ; 98(8): 543-546, 2016 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-27791410

RESUMEN

INTRODUCTION The roles of non-medically trained practitioners within the NHS are expanding; they are now being employed by many specialties, including surgery, to relieve pressures on healthcare teams. AIMS To investigate the learning curve and competence of an orthopaedic surgical care practitioner (SCP) in performing hip aspirations. METHODS Data were retrospectively collected on 510 orthopaedic hip aspirations, of which 360 were completed by a single SCP and 150 were completed by surgeons before the SCP took over routine aspiration. The 360 aspirations completed by an SCP were separated into groups of 30 by date, so any trend in failure rate could be analysed. Ordinal χ2 analysis was used to analyse this trend and Pearson χ2 analysis was used to analyse differences in failure rates between professionals. RESULTS The hip aspiration failure rate for the SCP was significantly lower than for the surgeons; 8.6% vs 20.7% (P<0.001). With the experience gained in completing the first 210 procedures, the failure rate of the SCP dropped to 3.3% for the remaining 150 procedures. This downward trend in hip aspiration failure rate, with advancing experience of the SCP, was shown to be statistically significant (P=0.006). DISCUSSION SCPs who complete hip aspirations on a regular basis have significantly lower failure rates than surgeons, probably as a result of the learning curve, which this study demonstrated. Other trusts should consider delegating routine hip aspiration work to a designated SCP to lower failure rates.


Asunto(s)
Artrocentesis/normas , Competencia Clínica , Articulación de la Cadera , Curva de Aprendizaje , Cirujanos/normas , Artrocentesis/educación , Humanos , Cirujanos/educación
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