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1.
Br J Sports Med ; 54(11): 627-630, 2020 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-31519545

RESUMEN

We aimed to establish consensus for reporting recommendations relating to participant characteristics in tendon research. A scoping literature review of tendinopathy studies (Achilles, patellar, hamstring, gluteal and elbow) was followed by an online survey and face-to-face consensus meeting with expert healthcare professionals (HCPs) at the International Scientific Tendon Symposium, Groningen 2018. We reviewed 263 papers to form statements for consensus and invited 30 HCPs from different disciplines and geographical locations; 28 completed the survey and 15 attended the meeting. There was consensus that the following data should be reported for cases and controls: sex, age, standing height, body mass, history of tendinopathy, whether imaging was used to confirm pathology, loading tests, pain location, symptom duration and severity, level of disability, comorbidities, physical activity level, recruitment source and strategies, and medication use history. Standardised reporting of participant characteristics aims to benefit patients and clinicians by guiding researchers in the conduct of their studies. We provide free resources to facilitate researchers adopting our recommendations.


Asunto(s)
Ensayos Clínicos como Asunto , Proyectos de Investigación , Tendinopatía , Humanos , Tendinopatía/diagnóstico , Tendinopatía/terapia
2.
Br J Sports Med ; 54(8): 444-451, 2020 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-31685525

RESUMEN

BACKGROUND: The absence of any agreed-upon tendon health-related domains hampers advances in clinical tendinopathy research. This void means that researchers report a very wide range of outcome measures inconsistently. As a result, substantial synthesis/meta-analysis of tendon research findings is almost futile despite researchers publishing busily. We aimed to determine options for, and then define, core health-related domains for tendinopathy. METHODS: We conducted a Delphi study of healthcare professionals (HCP) and patients in a three-stage process. In stage 1, we extracted candidate domains from clinical trial reports and developed an online survey. Survey items took the form: 'The 'candidate domain' is important enough to be included as a core health-related domain of tendinopathy'; response options were: agree, disagree, or unsure. In stage 2, we administered the online survey and reported the findings. Stage 3 consisted of discussions of the findings of the survey at the ICON (International Scientific Tendinopathy Symposium Consensus) meeting. We set 70% participant agreement as the level required for a domain to be considered 'core'; similarly, 70% agreement was required for a domain to be relegated to 'not core' (see Results next). RESULTS: Twenty-eight HCP (92% of whom had >10 years of tendinopathy experience, 71% consulted >10 cases per month) and 32 patients completed the online survey. Fifteen HCP and two patients attended the consensus meeting. Of an original set of 24 candidate domains, the ICON group deemed nine domains to be core. These were: (1) patient rating of condition, (2) participation in life activities (day to day, work, sport), (3) pain on activity/loading, (4) function, (5) psychological factors, (6) physical function capacity, (7) disability, (8) quality of life and (9) pain over a specified time. Two of these (2, 6) were an amalgamation of five candidate domains. We agreed that seven other candidate domains were not core domains: range of motion, pain on clinician applied test, clinical examination, palpation, drop out, sensory modality pain and pain without other specification. We were undecided on the other five candidate domains of physical activity, structure, medication use, adverse effects and economic impact. CONCLUSION: Nine core domains for tendon research should guide reporting of outcomes in clinical trials. Further research should determine the best outcome measures for each specific tendinopathy (ie, core outcome sets).


Asunto(s)
Tendinopatía/terapia , Actividades Cotidianas , Toma de Decisiones Conjunta , Técnica Delphi , Encuestas de Atención de la Salud , Humanos , Dolor/etiología , Calidad de Vida , Tendinopatía/complicaciones , Tendinopatía/psicología
4.
Br J Sports Med ; 48(21): 1553-7, 2014 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-23476034

RESUMEN

It is currently widely accepted among clinicians that chronic tendinopathy is caused by a degenerative process devoid of inflammation. Current treatment strategies are focused on physical treatments, peritendinous or intratendinous injections of blood or blood products and interruption of painful stimuli. Results have been at best, moderately good and at worst a failure. The evidence for non-infammatory degenerative processes alone as the cause of tendinopathy is surprisingly weak. There is convincing evidence that the inflammatory response is a key component of chronic tendinopathy. Newer anti-inflammatory modalities may provide alternative potential opportunities in treating chronic tendinopathies and should be explored further.


Asunto(s)
Tendinopatía/etiología , Antiinflamatorios/uso terapéutico , Enfermedad Crónica , Ciclooxigenasa 1/fisiología , Ciclooxigenasa 2/fisiología , Humanos , Inhibidores de la Metaloproteinasa de la Matriz/uso terapéutico , Metaloproteinasas de la Matriz/fisiología , Dolor Musculoesquelético/prevención & control , Neovascularización Patológica/patología , Neovascularización Patológica/fisiopatología , Sustancia P/fisiología , Tendinopatía/tratamiento farmacológico , Tendinopatía/patología , Tendones/irrigación sanguínea , Factor de Necrosis Tumoral alfa/antagonistas & inhibidores
5.
J R Army Med Corps ; 160(4): 310-3, 2014 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-24453354

RESUMEN

OBJECTIVES: The British military has a cohort of patients with ankylosing spondylitis (AS) characterised by young age and short disease duration. Many of the most severely affected AS patients have been treated since 2005 at Headley Court with anti-tumour necrosis factor (anti-TNF) therapy in accordance with National Institute of Health and Care Excellence guidance. We wanted to prospectively determine both the safety and efficacy of this new treatment in our British military population and compare this with relevant civilian study outcome data. METHODS: All AS patients commenced on anti-TNF therapy at Headley Court were prospectively monitored for treatment efficacy and side effects. Outcome measures used included the Bath Ankylosing Spondylitis Disease Activity Index. Our results were compared with a civilian comparison group (NHS) and relevant landmark clinical trial data. RESULTS: Our patients were younger (mean age 34.7 years) and had a shorter duration (mean disease duration 6.9 years) than the civilian (NHS) comparison group. Our safety data were extremely benign with only two patients suffering minor side effects (local injection site reaction). Furthermore, our outcome data were superior to both NHS routine care and to landmark clinical studies. DISCUSSION: Prior to this study, there were no data on military AS populations receiving anti-TNF therapy. The study confirms British military patients tolerate this therapy extremely well and receive greater benefit from this treatment than that seen in any published study to date. We believe that this confirms that young age and short disease duration are good prognostic factors in the treatment of AS with anti-TNF therapy.


Asunto(s)
Antiinflamatorios no Esteroideos/uso terapéutico , Personal Militar/estadística & datos numéricos , Espondilitis Anquilosante/tratamiento farmacológico , Factor de Necrosis Tumoral alfa/antagonistas & inhibidores , Adalimumab , Adulto , Antiinflamatorios no Esteroideos/efectos adversos , Anticuerpos Monoclonales Humanizados/efectos adversos , Anticuerpos Monoclonales Humanizados/uso terapéutico , Etanercept , Humanos , Inmunoglobulina G/efectos adversos , Inmunoglobulina G/uso terapéutico , Persona de Mediana Edad , Estudios Prospectivos , Receptores del Factor de Necrosis Tumoral/uso terapéutico , Espondilitis Anquilosante/epidemiología , Resultado del Tratamiento , Reino Unido/epidemiología , Adulto Joven
6.
Br J Sports Med ; 47(9): 536-44, 2013 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-23584762

RESUMEN

In September 2010, the first International Scientific Tendinopathy Symposium (ISTS) was held in Umeå, Sweden, to establish a forum for original scientific and clinical insights in this growing field of clinical research and practice. The second ISTS was organised by the same group and held in Vancouver, Canada, in September 2012. This symposium was preceded by a round-table meeting in which the participants engaged in focused discussions, resulting in the following overview of tendinopathy clinical and research issues. This paper is a narrative review and summary developed during and after the second ISTS. The document is designed to highlight some key issues raised at ISTS 2012, and to integrate them into a shared conceptual framework. It should be considered an update and a signposting document rather than a comprehensive review. The document is developed for use by physiotherapists, physicians, athletic trainers, massage therapists and other health professionals as well as team coaches and strength/conditioning managers involved in care of sportspeople or workers with tendinopathy.


Asunto(s)
Ejercicio Físico/fisiología , Deportes/fisiología , Tendinopatía/etiología , Tendón Calcáneo/lesiones , Colombia Británica , Diagnóstico por Imagen/métodos , Humanos , Dolor Musculoesquelético/etiología , Dolor Musculoesquelético/rehabilitación , Ligamento Rotuliano/lesiones , Lesiones del Manguito de los Rotadores , Tendinopatía/diagnóstico , Tendinopatía/rehabilitación , Traumatismos de los Tendones/diagnóstico , Traumatismos de los Tendones/etiología , Traumatismos de los Tendones/rehabilitación , Codo de Tenista/etiología , Codo de Tenista/rehabilitación , Resultado del Tratamiento
8.
Plant Biotechnol J ; 7(6): 499-511, 2009 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-19486323

RESUMEN

Despite the functional importance of histidine (His) as an essential amino acid in proteins and as a metal-coordinating ligand, comparatively little is known about the regulation of its biosynthesis in plants and the potential for metabolic engineering of this pathway. To investigate the contribution of different steps in the pathway to overall control of His biosynthesis, nine His biosynthetic genes were individually over-expressed in Arabidopsis thaliana to determine their effects on free amino acid pools. Constitutive, CaMV 35S-driven over-expression of the cDNAs encoding either isoform of ATP-phosphoribosyltransferase (ATP-PRT), the first enzyme in the pathway, was sufficient to increase the pool of free His by up to 42-fold in shoot tissue of Arabidopsis, with negligible effect on any other amino acid. In contrast, over-expression of cDNAs for seven other enzymes in the biosynthetic pathway had no effect on His content, suggesting that control of the pool of free His resides largely with ATP-PRT activity. Over-expression of ATP-PRT and increased His content had a negative pleiotropic effect on plant biomass production in 35S:PRT1 lines, but this effect was not observed in 35S:PRT2 lines. In the presence of 100 microM Ni, which was inhibitory to wild-type plants, a strong positive correlation was observed between free His content and biomass production, indicating that the metabolic cost of His overproduction was outweighed by the benefit of increased tolerance to Ni. His-overproducing plants also displayed somewhat elevated tolerance to Co and Zn, but not to Cd or Cu, indicating chemical selectivity in intracellular metal binding by His.


Asunto(s)
ATP Fosforribosil Transferasa/metabolismo , Proteínas de Arabidopsis/metabolismo , Arabidopsis/genética , Histidina/biosíntesis , ATP Fosforribosil Transferasa/genética , Aminoácidos/metabolismo , Arabidopsis/enzimología , Arabidopsis/crecimiento & desarrollo , Proteínas de Arabidopsis/genética , ADN Complementario/genética , Genes de Plantas , Metales/farmacología , Plantas Modificadas Genéticamente/enzimología , Plantas Modificadas Genéticamente/genética
11.
Am J Sports Med ; 37(9): 1855-67, 2009 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-19188560

RESUMEN

Overuse disorders of tendons, or tendinopathies, present a challenge to sports physicians, surgeons, and other health care professionals dealing with athletes. The Achilles, patellar, and supraspinatus tendons are particularly vulnerable to injury and often difficult to manage successfully. Inflammation was believed central to the pathologic process, but histopathologic evidence has confirmed the failed healing response nature of these conditions. Excessive or inappropriate loading of the musculotendinous unit is believed to be central to the disease process, although the exact mechanism by which this occurs remains uncertain. Additionally, the location of the lesion (for example, the midtendon or osteotendinous junction) has become increasingly recognized as influencing both the pathologic process and subsequent management. The mechanical, vascular, neural, and other theories that seek to explain the pathologic process are explored in this article. Recent developments in the nonoperative management of chronic tendon disorders are reviewed, as is the rationale for surgical intervention. Recent surgical advances, including minimally invasive tendon surgery, are reviewed. Potential future management strategies, such as stem cell therapy, growth factor treatment, and gene transfer, are also discussed.


Asunto(s)
Tendinopatía/terapia , Humanos , Tendinopatía/etiología , Tendinopatía/patología
12.
Plant Cell ; 17(7): 2089-106, 2005 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-15923352

RESUMEN

Plants that hyperaccumulate Ni exhibit an exceptional degree of Ni tolerance and the ability to translocate Ni in large amounts from root to shoot. In hyperaccumulator plants in the genus Alyssum, free His is an important Ni binding ligand that increases in the xylem proportionately to root Ni uptake. To determine the molecular basis of the His response and its contribution to Ni tolerance, transcripts representing seven of the eight enzymes involved in His biosynthesis were investigated in the hyperaccumulator species Alyssum lesbiacum by RNA gel blot analysis. None of the transcripts changed in abundance in either root or shoot tissue when plants were exposed to Ni, but transcript levels were constitutively higher in A. lesbiacum than in the congeneric nonaccumulator A. montanum, especially for the first enzyme in the biosynthetic pathway, ATP-phosphoribosyltransferase (ATP-PRT). Comparison with the weak hyperaccumulator A. serpyllifolium revealed a close correlation between Ni tolerance, root His concentration, and ATP-PRT transcript abundance. Overexpression of an A. lesbiacum ATP-PRT cDNA in transgenic Arabidopsis thaliana increased the pool of free His up to 15-fold in shoot tissue, without affecting the concentration of any other amino acid. His-overproducing lines also displayed elevated tolerance to Ni but did not exhibit increased Ni concentrations in either xylem sap or shoot tissue, suggesting that additional factors are necessary to recapitulate the complete hyperaccumulator phenotype. These results suggest that ATP-PRT expression plays a major role in regulating the pool of free His and contributes to the exceptional Ni tolerance of hyperaccumulator Alyssum species.


Asunto(s)
Brassicaceae/metabolismo , Resistencia a Medicamentos/fisiología , Histidina/biosíntesis , Níquel/metabolismo , ATP Fosforribosil Transferasa/genética , ATP Fosforribosil Transferasa/metabolismo , Arabidopsis/genética , Arabidopsis/metabolismo , Sitios de Unión/genética , Brassicaceae/efectos de los fármacos , ADN Complementario/genética , Evolución Molecular , Datos de Secuencia Molecular , Filogenia , Raíces de Plantas/efectos de los fármacos , Raíces de Plantas/metabolismo , Plantas Modificadas Genéticamente/genética , ARN de Planta/genética , Especificidad de la Especie
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